Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003873 (rheumatoid arthritis)
 53,068 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study, the polymorphisms of the HLA DMA and DMB genes in patients with rheumatoid arthritis (RA) were examined.DMA and DMB typing was performed in 120 white RA patients from eastern France and 100 healthy controls, using PCR-SSO (sequence specific oligonucleotide probes) method for DMA determination and PCR-RFLP (restriction fragment length polymorphism) method for DMB typing. All patients and controls had been HLA DRB1* genotyped.DMA*0103 was found significantly increased in RA patients (RA vs. controls: 18.3% vs. 4%) (p(corr) = 0.004; OR: 5.39; CI: 1.67-19.23). A decreased frequency of DMA*0102 was also observed in the RA group (RA vs. controls: 18.3% vs. 31%), but not significantly. There were no differences in the prevalence of DMB alleles between RA and controls. The patients and the controls were then stratified according to the expression of the HLA DRB1* RA-linked alleles (DRB1*01 and *04) and this allowed us to find no linkage disequilibrium between DMA*0103 and DRB1*01 or *04 alleles. Finally, most DMA*0103 patients were positive for rheumatoid factors and had extraarticular involvement such as subcutaneous nodules. Thus, our results suggest that DMA*0103 could be an additional genetic factor for RA susceptibility in French whites.
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PMID:The association of HLA-DM genes with rheumatoid arthritis in Eastern France. 1068 20

HLA DM is a heterodimeric molecule functioning in normal antigen presentation; it is encoded by adjacent HLA-region loci, HLA DMA and DMB, located between DP and DQ. Some previous studies have suggested that HLA susceptibility to rheumatoid arthritis (RA) is associated with certain DMA and DMB alleles. Our aim was to examine whether this association is also present in US Caucasians. We studied 288 US Caucasian subjects with rheumatoid arthritis and 263 US Caucasian control subjects. DMA and DMB typing was achieved by PCR amplification followed by sequence-specific oligonucleotide hybridization and by PCR-restriction fragment length polymorphism. There was no frequency difference for DMA alleles or DMB alleles between RA and control subjects, indicating no association. Neither was a difference apparent when data were analysed in subgroups based on shared-epitope DRB1, on the rheumatoid factor test, on radiographic changes of RA, or on sex. DRB1-DQB1-DMB analyses for linkage disequilibrium showed that the DRB1*0401-DQB1*0301 haplotype had the DMB*0103 allele more often than DMB*0101 (estimated haplotype frequencies 0.08 and 0.039 in RA, respectively). In contrast, the DRB1 *0401-DQB1 *0302 haplotype usually had the DMB*0101 allele (haplotype frequency 0.084 compared to 0.01 for DMB*0103). Thus, neither HLA DMA nor DMB was associated with RA in this population, and not all shared-epitope-bearing haplotypes had the same DMB allele distribution.
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PMID:HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians. 1188 21