Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003873 (rheumatoid arthritis)
 53,068 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty patients with classical or definite rheumatoid arthritis received one intra-articular injection of 40, 80, 120, 160 or 200 mg rimexolone (Org 6216) into one knee joint. Rimexolone was well tolerated and the incidence of side-effects was low. A beneficial effect was sustained over the study period of 94 days and a long-lasting effect was observed in 84% of the patients after one year and in 79% after 2 years. Safety parameters remained unaffected. Individual changes in adrenal response to ACTH and morning cortisol levels did not correlate with the dose or with serum levels of rimexolone. Rimexolone showed linear kinetics. The mean residence time in the intra-articular depot was 44 days (SD +/- 53) with a median of 26 days. Ninety percent was absorbed after 4 months. Outside the intra-articular depot the mean residence time was less than 0.1 days.
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PMID:A high dose (up to 200 mg) tolerance and efficacy study of intra-articular rimexolone (Org 6216) in rheumatoid synovitis of the knee. 818 28

Rimexolone is a locally active nonfluorinated glucocorticoid which has minimal systemic effects and is virtually devoid of any atrophogenic effects on the skin.It has high corticosteroid receptor affinity and remains localised at the injection site for a prolonged period after intra-articular injection. Thus, serum rimexolone concentrations remain low.Rimexolone had the longest mean intra-articular residence time of several intra-articular steroid preparations (25 days, vs 6 days for triamcinolone hexacetonide and 1 to 4 days for the other drugs, which included methylprednisolone acetate).Single intra-articular injections of rimexolone provided long-lasting improvement of clinical efficacy parameters in patients with rheumatoid arthritis or osteoarthritis.In patients with rheumatoid arthritis, rimexolone was superior to placebo for treating knee joints and superior to placebo and similar to methylprednisolone acetate for treating small joints of the hand.In patients with osteoarthritis of the knee joint, rimexolone was superior to placebo, tended to be slightly more effective than methylprednisolone acetate and was similar to triamcinolone acetonide or a depot preparation of betamethasone dipropionate.
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PMID:[Not Available]. 1803 Oct 88