Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003873 (rheumatoid arthritis)
 53,068 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An osteosclerosis opacifying the axial skeleton and affecting in particular all of the spine, was observed in two women aged 75 and 42 years who had been suffering from a rheumatoid arthritis developing between 15 and 26 years. It was traced to a chronic fluorine intoxication, stemming from the regular taking, for 10 years and 8 1/2 years, of a non cortisone, anti-inflammatory niflumic acid. This fluorine product has 3 atoms of fluor in its molecule (50.0 mg for a tablet of 250 mg). Its administration to control subjects proved the production of ionized fluor by way of the metabolism, and the accumulation of fluor in the organism. Rheumatoid polyarthritis and the prolonged corticotherapy (10 mg of prednisone per day for 21 years) cannot be dismissed as the origin of the severe demineralization of the limbs observed in the second patient, but the role of fluorine seems marked in the occurrence of this peripheral involvement with problems of mineralization and secondary hyperparathyroidisms. On the other hand, the absence of an intervertebral narrowing in the 2 patients, despite the very prolonged taking of cortisone (5 mg of prednisone per day for 15 years, for the 75-year-old patient) is perhaps a result of the fluorine.
Rev Rhum Mal Osteoartic 1978 Dec
PMID:[Fluorine osteosis caused by a very long-term niflumic acid treatment in 2 cases of rheumatoid arthritis]. 10 72

We have studied the in vitro antibody response to a hapten of peripheral blood lymphocytes from 26 patients with rheumatoid arthritis and 7 ankylosing spondylitis. These patients had never received immunosuppressor drugs before or corticosteroids during the month before the test. They had failed to receive aspirin or non-steroid anti-inflammatory drugs for 72 hours before blood sampling. The control groups included respectively 38 healthy subjects and 24 patients hospitalized for non inflammatory disease. The antibody response of ankylosing spondylitis patients is comparable to that of controls ; on the opposite the response of patients with rhumatoid arthritis is significantly depressed in comparison with the three other groups. The weak response of lymphocytes in arthritis is not due to increased cell death in culture or to modified kinetics of the antibody response or to the appearance of a IgG secondary type response or a in vivo pre-activation. The lymphocytes of arthritis patients do not inhibit the response of normal lymphocytes when they are co-cultured. The observed response is identical to that obtained when control patient lymphocytes are co-cultured with normal lymphocytes. The function of suppressor T cells induced by Con A seems normal in spondylitis and arthritis.
Rev Rhum Mal Osteoartic 1979 Dec
PMID:[In vitro study of the primary antibody response of circulating lymphocytes in patients with chronic inflammatory rheumatism]. 16 Oct 63

By using an osteotropic complex (99mTc pyrophosphate) scintigraphic and scintiphotographic images were obtained with a view to studying the bone changes in inflammatory arthropathies. In rheumatoid arthritis there is an increase in radioactivity next to affected joints and this phenomenon which seems to contrast with the osteoporosis of the juxta-articular regions is confirmed, since the reduced density that is observed in the radiograms is a result of the lack of equilibrium between bone formation and bone resorption, but only if these two processes are proceeding actively. The "warm" zones, which are very close to the joints, are just as easy to see in relation to inflamed joints as they are in relation to joints in which the inflammation has ceased. Not all the inflamed joints accumulate the radioactive osteotropic complex. The bone changes can occur in cases of chronic inflammatory arthropathies only if the inflammation has been present for at least several months. The images obtained with the polyphosphate correspond to those that can be obtained with other calcium-mimetic and osteotropic isotopes (Sr etc.).
Rev Rhum Mal Osteoartic
PMID:[Use of new osteotropic isotopes in osteoarticular diseases, with special reference to phlogistic arthropathies]. 17 Jun 64

In inflammatory granuloma, synovial sclerosis or inflammation and in Dupuytren's contracture, the neocollagen contains chains and/or transverse links that are characteristic of rapidly growing immature tissues. In arthrosis, a conversion of collagen synthesis towards a cutaneous type may occur. The destruction of cartilage in rheumatoid arthritis is brought about by a specific collagenase that originates from the inflamed synovial membrane. Finally, certain forms of osteoporosis may be due to alterations of the osseous collagen which impair the mechanism of calcification.
Rev Rhum Mal Osteoartic 1977 Mar
PMID:[Biochemistry of collagen and locomotor apparatus. Hereditary diseases of the connective tissue and rheumatic diseases (3)]. 19 5

A study was made of 45 patients suffering from hydroxyapatite rheumatism (multiple tendon calcifications disease). There were 36 women and 9 men aged between 15 and 61 years with an average age of 14. The following joints were involved (the first figure refers to clinical affection, that between brackets to radiologically demonstrable calcifications): shoulder 34 (36); neck 14 (15); wrist 18 (11); fingers 19 (17); hip 11 (29); knee 14 (18); ankle 10 (14); foot 5 (6); spinal column 16 (24). In 30 patients the disease manifested itself in the form of acute recurrent migratory arthritis resembling gout. In 8 cases, it developed in the form of acute recurrent migratory arthritis resembling gout. In 8 cases, it developed in the form of acute polyarthritis and in 7 as rheumatoid arthritis without radiological lesions. Thirty-two patients could be followed up. Four of them were cured, 9 showed improvement but still suffered attacks of pain. Eighteen patients were not improved, their pains growing more chronic. Four patients had a family history of multiple tendon calcifications disease.
Rev Rhum Mal Osteoartic 1977 May
PMID:[Hydroxyapatite rheumatism (multiple tendon calcification disease). I.- Clinical study]. 30 25

The responsiveness to mitogens of the in vitro cultural peripheral blood lymphocytes from 60 patients with rheumatoid arthritis (RA) and from controls was evaluated in terms of H3 TdR uptake. The size of the response was tested for a correlation with the percentages of T and B lymphocytes, determined by E and EAC rosette test, as well as with the various alterations of the clinical and biological parameters. In the RA cultures an elevated level of spontaneous H3 TdR uptake was found, which could be an in vitro carry-over of an activation in vivo. No significant statistical differences were found between rheumatic and control groups as regards: 1 degrees--the H3 TdR uptake induced both by PHA and SLO; 2 degrees--the proportion of the circulating T and B lymphocytes. The only positive correlation evidenced by this study in RA patients was that between the proportion of B lymphocytes and the gammaglobulin level in the plasma.
Rev Rhum Mal Osteoartic 1978 Jun
PMID:[Study of cellular immunity in rheumatoid arthritis]. 30 52

Anti-IgG antibodies were studied in 222 patients hospitalized in a Rheumatology service using "radio-immuno-precipitation-PEG-assay" (RIPEGA), The presence of anti-IgG antibodies was observed in 94 per cent of sero-positive rheumatoid arthritis (RA+), 88 percent of seronegative rheumatoid arthritis (RA--), 50 percent miscellaneous chronic inflammatory rheumatisms (CIR) and 77 percent of no-classifiable chronic inflammatory rheumatisms. The study of circulating immune complexes (CIC) using the CIC-125 I linkage tests, carried out on 101 RA cases, demonstrated their presence in 80 per cent of RA+ and 85 per cent of RA--. The comparison of these two factors during RA showed a concordant relationship that was statistically significant. The presence of the rheumatoid factor (RF) in the form of complexes in the blood stream, is discussed.
Rev Rhum Mal Osteoartic 1978 Jun
PMID:[Circulating immune complexes and anti-IgG antibodies in rheumatoid arthritis]. 30 54

Fifty sera containing antinucleolar antibodies were o gathered in a routine laboratory during testing for antinuclear antibodies with indirect immun-fluorescence over a five-year period. The patients involved were suffering from sclerodermia (13 cases), rheumatoid arthritis (7 cases), polymyositis (3 cases), lupus (2 cases), various rhumatismal disease (59 cases) and non rhumatismal diseases in 16 cases, including 5 malignant diseases. In 80 per cent of the cases nucleolar fluorescence was combined with nuclear fluorescence of another type. The antibodies were almost always of the IgG category and belonged in 2/3 of cases to several immunoglobulin categories, most often IgG-IgA. Pretreatment of the liver cuttings with RNase always modifies the nucleolar fluorescence, most often making it negative, and pretreatment with DNase using a combination of enzymes 10 times higher also modifies it (more often decreasing it than making it negative), which indicates that the nucleolar antigen, probably an ARN with a low molecular weight, also depends upon the ADN.
Rev Rhum Mal Osteoartic 1979 Jun
PMID:[Antinuclear antibodies: immunological characteristics and clinical significance]. 31 10

Albuminemia, calcemia, phosphoremia and alcaline phosphatasemia were measured in three groups of 52 subjects each : rheumatoid arthrits, inflammatory rheumatisms other than rheumatoid arthritis and lumbarthrosics serving as a reference group. Calcemia and albuminemia were significantly lower in patients suffering from rheumatoid arthritis, whose calcemia corrected in relation to albuminemia is, on the other hand, normal : the increase in corrected calcemia pointed out by Kennedy, was not noted. Corrected calcemia was also normal in ankylosing spondylitis, but it was significantly higher in polymyalgia rheumatica. Phosphoremia was shown to be normal but alkaline phosphatases were higher than normal in the three groups.
Rev Rhum Mal Osteoartic 1979 Jun
PMID:[Changes in blood calcium, phosphorus and alkaline phosphatase levels in rheumatoid polyarthritis and other types of inflammatory rheumatism]. 31 11

The sera of 161 subjects hospitalized in a rheumatology department were tested for anti-IgG antibodies using a "PEG radioimmunoprecipitation assay" (RIPEGA), for circulating immune complexes using the liaison test with Clq 125I, and dosage of complement and its metabolites. No significant difference was found between the group of 37 ankylosing spondylitis and the group of 44 control subjects. The results were identical, whatever the form of the disease, be it peripheral or central, and evolutive or non evolutive. On the contrary, the study of the rheumatoid arthritis (47 seropositive and 34 seronegative) provided results in conformity to previous works. The different physiopathogenic origin of these two chronic inflammatory rheumatisms is discussed by the authors.
Rev Rhum Mal Osteoartic 1979 Jun
PMID:[Absence of circulating immune complexes and of serum anti-IgG antibodies during ankylosing spondylarthritis]. 31 12


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