Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003873 (rheumatoid arthritis)
 53,068 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report here on 41 male patients with acute polyarticular gout seen in 3 years. Acute polyarticular gout continues to masquerade as other commoner rheumatological disorders such as septic arthritis, rheumatoid arthritis, degenerative joint disease, and even hemiparesis. Almost all of these patients had clues to the diagnosis of acute gout in their medical history. These clues included a past history of intermittent acute gout, prior attacks of polyarticular arthritis, previous hyperuricaemia, and/or obvious tophi. The patients all responded promptly to nonsteroidal anti-inflammatory drugs. We observed serious toxic drug reactions in 8 patients.
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PMID:Acute polyarticular gout. 684 58

Of 314 patients with proved pseudogout, 9 had a separate serious disease in the same joint: 5 had septic arthritis, 2 rheumatoid arthritis, 1 psoriatic arthritis, and 1 hypertrophic pulmonary osteoarthropathy. In every instance but one, the episode of crystal synovitis appeared to be provoked by the new inflammatory process, disturbing previously asymptomatic chondrocalcinosis. Pseudogout attacks, although generally idiopathic solo events, can mask septic and chronic inflammatory arthritis.
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PMID:Pseudogout masking other arthritides. 688 68

Three patients with severe ulnar deviation and metacarpophalangeal joint subluxation are described. They were all elderly women with interphalangeal joint osteoarthritis but no other rheumatic disease. The clinical appearance of the hands led to an incorrect diagnosis of rheumatoid arthritis in each case. Two were taking corticosteroids, predisposing to septic arthritis in one. Rheumatoid-like deformities may be common in the elderly.
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PMID:Pseudo-rheumatoid deformity in elderly osteoarthritic hands. 688 75

Lactic acid concentrations in the synovial fluid of 71 patients with inflammatory arthritis were determined by an enzyme method. In 63 samples from 54 patients with a variety of non-septic arthritides, including rheumatoid arthritis, reactive arthritis and gout, the concentration of lactic acid was never greater than 10.2 mmol/l, whereas all twelve patients with septic arthritis had concentrations of 11 mmol/l or greater. Two patients with gonococcal arthritis did not have raised lactic acid concentrations. The enzyme method of lactic acid estimation is an accurate reproducible means of differentiating septic from nonseptic arthritis prior to the isolation of the infecting organism. However, caution is necessary when interpreting the results in those patients who have recently received antibiotic therapy, or in whom gonococcal arthritis is suspected.
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PMID:Synovial fluid lactic acid in septic arthritis. 694 53

Gram-negative septic arthritis is an uncommon but serious complication of rheumatoid arthritis and is usually mono-articular. The present case is unusual in that a septic polyarthritis due to Bacteroides fragilis developed in nine joints. The organism was grown only in anaerobic synovial fluid and blood cultures. The patient recovered after treatment which included repeated needle aspirations of the joints under anaesthesia and oral metronidazole (Flagyl; Maybaker). Any patient with rheumatoid arthritis who develops an acute flare-up of disease in one or more joints should have these aspirated to exclude the possibility of septic arthritis. Both anaerobic and aerobic cultures of synovial fluid and blood should be done. Prompt antibiotic treatment and joint drainage are the cornerstones of treatment.
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PMID:Septic polyarthritis due to Bacteroides fragilis in a patient with rheumatoid arthritis. A case report. 710 Oct 73

Chondrocalcinosis is an arthropathy caused by deposits of calcium pyrophosphate-dihydrate microcrystals (CPPD) in the joints and occasionally in the tendons and ligaments. In our region it is almost always seen in its sporadic form in elderly subjects. The patients can be without symptoms or present four different clinical entities: an acute arthritis which can resemble and even be mistaken for an attack of gout or a septic arthritis; an inflammatory polyarthritis suggesting a rheumatoid arthritis; most frequently it appears as a benign polyarthrosis; sometimes it runs a destructive course capable of seriously damaging one or several joints. In certain cases chondrocalcinosis is associated with another metabolic disease. Familial forms have been described in some countries. Factors which induce the formation of the deposits of CPPD in the articular cartilages, fibrocartilages, the synovium and occasionally in the tendons and ligaments remain obscure. In contrast to urate gout, chondrocalcinosis appears to be due to a disturbance of pyrophosphate metabolism localized almost exclusively in the articular region. Its association with polyarthrosis rather frequently leads to destructive arthropathies. No etiological treatment for chondrocalcinosis exists at the present time. Therapy is limited to the administration of nonsteroidal antiinflammatory drugs and physiotherapy.
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PMID:[Chondrocalcinosis]. 711 58

A patient with rheumatoid arthritis developed an infection in the right hand after she administered an antibiotic capsule to her cat. Two weeks after this, septic arthritis developed in her right knee. The organism isolated was Pasteurella multocida, which is part of the feline normal oral flora. The infection was treated with penicillin and drainage.
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PMID:Septic arthritis caused by Pasteurella multocida. 713 53

A series of 92 patient who underwent excision arthroplasty of the hip (Girdlestone arthroplasty) as a primary procedure is presented. The operation was performed for various conditions which included femoral neck fracture, rheumatoid arthritis, ankylosing spondylitis, tuberculosis, septic arthritis, unreduced posterior dislocation of long duration, fracture of the acetabulum, avascular necrosis of femoral head and bony ankylosis. Excision of head and neck of the femur was found to be an excellent salvage procedure for infected hips especially yielding uniformly satisfactory results at all ages irrespective of the disease. It provided a painless, mobile hip. Except for shortening and unstable gait, no other handicap was observed; the disadvantages of this handicap were outweighed by its advantages, compared with the disadvantages of other sophisticated hip operations such as replacement, and mould arthroplasties or even total hip replacement. Our results were excellent in 21% of cases, good in 44% and fair in 26% while they were poor in 9%. In view of its functional end results, we feel that this measure can be a good alternative to more modern and sophisticated hip operations in the form of partial or total hip replacement under Indian conditions.
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PMID:Girdlestone arthroplasty. 718 46

Thirteen patients suffering from rheumatoid arthritis had 19 stress fractures of the tibia or fibula. These patients characteristically presented with sudden, severe, unexplained pain with localised tenderness just below the knee or above the ankle. In seven patients examination of the adjacent joint indicated a flare-up of disease activity or a pyogenic arthritis. In six patients the diagnosis was delayed by the late appearance of callus in minute fractures. All patients had rheumatoid deformities of the ipsilateral lower limb: valgus deformities of the knee and subtalar joints occurred most frequently. All patients had osteoporosis; all except two had received steroid treatment and five had abnormalities of calcium metabolism. We suggest that deformities of the knee and ankle predispose patients with rheumatoid arthritis and osteoporosis to stress fractures of the tibia and fibula.
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PMID:Stress fractures of the lower limb in patients with rheumatoid arthritis. 721 49

329 synovial fluids from various joint diseases were examined. 95% of the fluids from arthrosis contained less than 1 000 cells/ml, figure which seemed to us to be the limit which separates arthrosis from arthritis. Above 100.000 cells/ml, the diagnosis is always pyogenic arthritis. Between 50.000 and 100.000 cells/ml, one may find pyogenic arthritis but also a few cases of rheumatoid arthritis, psoriatic rheumatism, gout and pseudo-gout. In chondrocalcinosis, the fluid variable, often poor in cells. The percentage of polymorphs is of little diagnostic interest; it exceeds 50% in all cases of pyogenic arthritis. R.A. cells are almost constant in fluids with more than 1 000 cells/ml and their diagnostic interest is not great.
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PMID:[Results of the cytological examination of the synovial fluid in various arthropathies]. 722 54


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