Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003873 (rheumatoid arthritis)
 53,068 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

MRI was used to evaluate inflammatory synovial processes in 53 patients over a 4-year period. Multiple disease processes were imaged, including: rheumatoid arthritis [n = 12], osteochondromatosis [n = 6], bursal abnormalities [n = 17], ganglion cyst [n = 1], meniscal cyst [n = 5], hemophilia [n = 1], and septic arthritis [n = 11]. The soft tissue contrast resolution of MRI and its multiplanar capability makes it particularly suitable for evaluating masslike or fluid inflammatory processes for diagnostic purposes, to determine extent of disease, and in some cases, to determine the composition of the inflammatory processes.
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PMID:MRI of inflammatory synovial processes. 260 1

Salmonella bacteremia is more frequently seen in hospitalized patients with systemic lupus erythematosus (SLE) than in hospitalized patients with other diseases. In our experience. Salmonella enteritidis septic arthritis is more common in SLE than in patients with others connective tissue diseases. We report that 4 of 7 patients with SLE with glomerulonephritis and history of Salmonella enteritidis septic arthritis were chronic carriers of this bacteria, since positive cultures were obtained from feces, bone marrow and bile fluid from 20 84 months after Salmonella arthritis developed. In contrast, none of 24 patients with SLE without a history of Salmonella arthritis were chronic carriers and only one of 12 patients with rheumatoid arthritis had positive bile culture to S. typhi while otherwise being asymptomatic. From our study we conclude that patients with active SLE who have gomerulonephritis are at increased risk of becoming chronic carriers of Salmonella enteritidis and of developing Salmonella arthritis once combined prednisone cyclophosphamide treatment has begun. A chronic Salmonella carrier state must be ruled out in patients with active SLE living in endemic zones, before initiating immunosuppressive therapy.
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PMID:Salmonella septic arthritis in systemic lupus erythematosus. The importance of chronic carrier state. 266 65

The results of arthroscopy or arthroscopic synovectomy on 31 ankle joints in 24 cases were reported. All the patients were followed for 2 to 10 months with an average of 6 months. The results were as follows of the 26 rheumatoid arthritis: excellent in 5 ankles (19.2%), good in 8 (30.8%), fair in 7 (26.9%), and poor in 6 (23.6%), of the three traumatic arthritis: good in one and fair in two; of the remaining 2: good in 1 tuberculous synovitis and fair in 1 chronic pyogenic arthritis. The operative procedure, indications and value of ankle arthroscopy together with its advantages were discussed in detail.
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PMID:[Ankle arthroscopy in clinical application: a preliminary report]. 277 31

Bacterial arthritis causes rapid damage of the affected joint. Knowledge of the source of the infection that leads to septic arthritis is necessary to judge possible preventive measurements. In this study we tried to detect the source of the infection in 77 episodes of bacterial arthritis in 73 patients admitted in the period 1976-1986. The source of infection was: a joint operation in 21, the skin in 15, the respiratory tract in 7, the genital tract in 8, others in 5, and unknown in 21. A skin infection was the source in patients suffering from rheumatoid arthritis. To our surprise in none of our cases was non-sterile surgery the cause of infection. Our results suggest that since perioperative joint infection is frequent, prevention of such infection may be meaningful. Skin infections are often the source of infection in rheumatoid arthritis, preventive measures are to be considered. Our results do not allow a judgment on the possible preventive measures for the other sources of infection detected or undetected. Administration of antibiotics during non-sterile surgery is not supported by the results of this study.
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PMID:[Bacterial joint infections: a retrospective study for the source of the infection]. 279 80

A case of acute hip pain in rheumatoid arthritis is presented, with synovial membrane findings. A patient with classical rheumatoid arthritis suffered three unusual bouts of sudden, severe but transient hip pain. The hips were clinically normal between these episodes. The clinical picture on two of these occasions strongly suggested septic arthritis. Although the synovial fluid was highly inflammatory, cultures were negative. The synovial membrane showed mild lining cell hyperplasia, vascular congestion, and scattered inflammatory cells, predominantly lymphocytes. These findings were not compatible with either pyogenic infection or longstanding rheumatoid arthritis. The clinical and pathological features of acute non-infectious arthritis of the hip appear to delineate a distinct syndrome.
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PMID:Acute non-infectious arthritis of the hip in rheumatoid arthritis: synovial membrane findings. 293 Feb 81

Eleven patients with rheumatoid arthritis that had been refractory to conventional drug therapy were treated with total lymphoid irradiation (TLI). Followup continued for 6 months in 9 patients, 12 months in 6 patients, and 24 months in 3 patients. At 6 and 12 months post-TLI, a significant improvement in clinical disease activity was demonstrated. Side effects noted during TLI included fatigue, nausea, diarrhea, and vomiting. One patient died of cardiorespiratory arrest, 2 patients died of kidney failure secondary to generalized amyloidosis, and 1 patient died of septic shock secondary to a multilocular septic arthritis. One patient experienced 2 episodes of septic arthritis; 2 patients manifested delayed wound healing. Immunologic assessments showed consistent lymphopenia in all patients. T lymphocyte subsets decreased after TLI, and showed a transient increase at 6 months post-TLI. The suppressed mitogen responsiveness, which was noted 2 months after irradiation, was found to increase almost to the pre-TLI levels at 12 months. The observed increase in morbidity and mortality after TLI is evidence that discourages the use of this therapeutic technique, at least in its present form.
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PMID:Total lymphoid irradiation in patients with refractory rheumatoid arthritis. 293 45

A 60-year-old woman with rheumatoid arthritis developed acute emphysematous septic arthritis of the knee due to Klebsiella pneumoniae. She was brought to the hospital in septic shock with disseminated intravascular coagulation and had striking physical signs and roentgenograms showing distention of the knee with gas. She also had an infection of the hand with subcutaneous gas. After surgical drainage and institution of antibiotic therapy, she remained critically ill for several days but gradually improved. Two months later, she was ambulating independently. Emphysematous septic arthritis is rare. Four cases have previously been reported, but none were caused by Klebsiella.
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PMID:Emphysematous septic arthritis due to Klebsiella pneumoniae. 327 11

We recommend that physicians distinguish shoulder arthritis from periarticular disorders. A specific diagnosis should be made in the former, if possible. A number of arthritides have frequent shoulder involvement, and they should be kept in mind. Septic arthritis should always be suspected when there is acute pain and swelling. Joint fluid aspiration should almost always be performed when fluid is present. The diagnosis of gout or CPPD deposition disease usually requires crystal identification from joint fluid for diagnosis. Treatment of shoulder arthritis with oral anti-inflammatory medication is usually indicated; appropriate treatment of the underlying disorder, e.g., rheumatoid arthritis, is necessary. Physical therapy started early, often combined with IA corticosteroids, helps to maintain or improve shoulder motion.
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PMID:Causes and management of shoulder arthritis. 327 36

The categorization in four classes of association between infection and arthritis (namely infective, post-infective, reactive and idiopathic) seems nowadays to be inadequate to cover the extensive field of interactions between infectious agents and host response resulting in arthritis. This paper is a synthetic review of the subject with particular reference to pathogenetic mechanisms in children. An effort has been accomplished, on the basis of the most recent literature, to define the respective roles of the microbial aggression and the host response in a number of conditions: septic arthritis, viral arthritides, Lyme arthritis, rheumatic fever, Reiter's syndrome, ankylosing spondylitis and rheumatoid arthritis.
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PMID:Infection and arthritis. 333 Feb 97

Bacterial infection of the sternoclavicular joint is an unusual event, with cases being reported in those with diabetes mellitus, in intravenous drug abusers, and in patients afflicted with rheumatoid arthritis. A case of this unique infection occurred in a person not known to be at risk for septic arthritis. Our report shows the difficulty in diagnosing this disorder.
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PMID:Sternoclavicular bacterial arthritis. 336 64


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