Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003873 (rheumatoid arthritis)
 53,068 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Radiologic assessment of the stage and treatment response of rheumatoid arthritis (RA) is based on the presence of bone erosions, joint-space narrowing, and osteoporosis. Most radiologic methods for staging RA lack interobserver correlation and are time consuming. Magnetic resonance (MR) imaging provides excellent depiction of soft-tissue abnormalities of the joints affected by RA, which allows detection of early changes. Nineteen joints of 17 patients with RA were studied with surface-coil MR imaging. Measurable abnormalities demonstrated by MR imaging but not clearly seen on plain radiographs included bone erosions, joint effusion, synovial sheath effusion, and cartilage irregularity and thinning. Seven patients of this group underwent MR imaging before and after 6 months of gold therapy. Four patients had significant interval changes on MR images that were not seen on plain radiographs. MR imaging may become a sensitive and objective method for quantitative assessment of the joint changes of RA.
 ...
PMID:Rheumatoid arthritis: MR imaging manifestations. 362 62

1. A radiometer is described, which is sensitive to infrared radiation in the range 0-25 mum, and which, after calibration with a black body standard can be used as a non-contact, fast reading thermometer.2. An example of acute joint inflammation in a patient with rheumatoid arthritis is described. The temperatures over the joint measured by radiometry, followed inflammatory changes in the joint effusion.3. Using rats, the method of measuring inflammation by radiometry was compared with measurements of increase in joint size. Changes measured by radiometry preceded changes shown by increase in joint size.4. The radiometer method was able to demonstrate the effect of an anti-inflammatory drug, given orally, against carrageenin inflammation.5. The procedure was found to be an accurate means of measuring inflammation and the anti-inflammatory effects of drugs. It was faster and less tedious than the other methods for the quantitative measurement of inflammation in man and animals.
 ...
PMID:Measurement of inflammation in man and animals by radiometry. 501 34

Synovial fluid total, dialysable and non-dialysable hydroxyproline were determined in patients with Rheumatoid Arthritis before intra-articular osmic acid injection and on days 2 and 4 after this local treatment. On day 2 the increase in dialysable hydroxyproline paralleled the increase in non-dialysable hydroxyproline. Patients with the highest pre-treatment dialysable hydroxyproline levels also had the highest levels of this fraction on day 2 suggesting that articular damage proceeds after osmic acid injection. However, on day 4 dialysable hydroxyproline levels were consistently lower than before the treatment; the same pattern was observed with non-dialysable hydroxyproline, except for all the joints but one, where effusion recurred 6-12 months after osmic acid treatment. This study suggests that the determination of synovial fluid non-dialysable levels 4 days after osmic acid injection may provide a clue to the prediction of recurrent joint effusion and possibly justify a complementary injection either with osmic acid or with a beta-emitting isotope.
 ...
PMID:Synovial fluid hydroxyproline fractions before and after osmic acid treatment in rheumatoid arthritis. 722 95

Rupture of a Baker's cyst may mimic thrombophlebitis of the leg clinically. Differentiation of these two entities is important because of therapeutic implications. A history of previous disease involving the knee, especially rheumatoid arthritis, or the finding of joint effusion are suggestive of the diagnosis of ruptured Baker's cyst. This may be confirmed by arthrography. We describe a series of eight patients with the "pseudothrombophlebitis" syndrome. Arthrography showed seven as having a ruptured Baker's cyst, while in one an intact cyst was found.
 ...
PMID:Ruptured Baker's cyst: a radiological diagnosis. 733 44

Indoprofen was given intravenously (bolus followed by infusion) and orally to 7 patients suffering from active rheumatoid arthritis with knee joint effusion. Indoprofen readily penetrated into synovial fluid in amounts which were directly correlated with areas under curves of plasma drug levels. Synovial fluid acted as a compartment distinct from the central (plasma) compartment. Indoprofen caused a substantial decrease in E2 and F2 alpha prostaglandin concentration in synovial fluid.
 ...
PMID:Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis. 743 27

Imaging methods have traditionally been the primary tools for documenting disease severity and progression. Radiographic methods are insensitive to early changes but eventually reflect the degree of bone destruction, cartilage space narrowing, and deformity that has occurred. Microfocal radiography is being investigated as a method to better define early erosive changes. Neither technique allows optimal examination of soft tissues (e.g., joint effusion, pannus, ligaments, and tendons). Magnetic resonance imaging (MRI) allows both soft tissues and bones to be examined. Articular cartilage imaging is currently under investigation. Despite its high cost, the noninvasive nature of MRI and the extensive information it provides, make this an exciting area for investigating the changes in rheumatoid arthritis and response to therapy.
 ...
PMID:Imaging techniques in rheumatoid arthritis. 782 13

Increased catalytic activity of synovial-type (group II) phospholipase A2 (syn-PLA2), has been associated with cartilage erosions in rheumatoid arthritis and osteoarthritis. The catalytic activity of phospholipase A2 and the concentration of syn-PLA2 were measured in a prospective study in synovial fluid (SF) samples from 66 patients with acute knee joint effusion. The median (range) of the concentration of syn-PLA2 in SF was 210 micrograms/l (80-1480 micrograms/l) in culture-positive septic arthritis, 460 micrograms/l (270-1040 micrograms/l) in reactive arthritis, 780 micrograms/l (120-2710 micrograms/l) in osteoarthritis and 230 micrograms/l (80-1400 micrograms/l) in traumatic joint effusions. High concentrations of syn-PLA2 are found also in SF of patients with arthritides not expected to lead to permanent destruction of cartilage.
 ...
PMID:Group II phospholipase A2 in synovial fluid and serum in acute arthritis. 816 40

Magnetic resonance imaging methods are described for measurement of disease activity in knee in rheumatoid arthritis patients. Measurements of cartilage thickness, joint effusion volume, and pannus volume have been made. The latter measurement relies on synthetic fractional enhancement images of the response to gadopentetate dimeglumine.
 ...
PMID:Magnetic resonance methods for measurement of disease progression in rheumatoid arthritis. 823 67

To evaluate the ability of ultrasonography with high frequency transducer (13-MHz) in detecting metacarpophalangeal (MCP) joint abnormalities, 20 patients with rheumatoid arthritis (RA) and a symptomatic involvement of MCP joints were studied. Twenty healthy subjects served as controls. In all RA patients, ultrasonography clearly demonstrated one or more soft tissue and/or bone abnormalities. Sixteen patients (80%) had joint cavity widening because of effusion (1 case), synovial thickening (7 cases), and joint effusion with synovial thickening (8 cases). Loss of definition of the metacarpal articular cartilage was observed in 17 cases (85%). Sixteen (80%) had bone erosions and 9 (45%) showed a definite widening of the flexor tendons sheath. Margin irregularities of the extensor and flexor tendons were respectively visualized in 7 (35%) and in 8 (40%) cases. An extensor tendon rupture was observed in 2 cases (10%). Ultrasound examination by 13-MHz transducer appears to increase the accuracy of MCP joints evaluation in RA with respect to conventional radiography. It can be recommended as the first investigation in the assessment of soft tissue involvement in RA patients.
 ...
PMID:Ultrasound examination of metacarpophalangeal joints in rheumatoid arthritis. 823 95

After clinical and radiological examination, the elbows of 74 patients with rheumatoid arthritis were examined by ultrasound. Clinical examination gives a good impression of the inflammatory changes of the elbow joint. Sonography was very useful in detecting synovitis and joint effusion and their distribution in the different parts of the joint. It is a good method to document the therapeutic effects; therefore, beside the clinical and radiological findings ultrasound may be helpful in planning further therapeutic measures for the patient.
 ...
PMID:[Ultrasound study of the elbow joint in patients with chronic inflammatory joint diseases--an enrichment of diagnosis?]. 836 20


<< Previous 1 2 3 4 5 6 7 8 9 Next >>