Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003864 (arthritis)
 69,039 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors reviewed the files of male patients who have been hospitalized over a 12 year period for a rheumatoid-factor negative arthritis beginning after age 50. Polymyalgia rheumatica, psoriasis or crystal-induced arthritis were excluded. The remaining 105 observations were classified according to published criteria in rheumatoid arthritis (RA), reactive arthritis or ankylosing spondylitis (AS). Twenty-nine patients had RA and 29 had AS with equal numbers of axial and peripheral types. Four patients had reactive arthritis, one of them had also AS. Forty-four patients had "unclassified arthritis". Among the latter, 14 were B27 positive, 21 were B27 negative, 9 were not typed. Some features were more frequent in B27+ patients: an assymetrical oligoarthritis of the lower limbs with minimal signs of inflammation at synovial analysis or at synovial biopsy; frequent unilateral edema; marked, constitutional signs; very high ESR. Nine patients, all B27+, met the diagnostic criteria of spondylarthropathy. B27 typing thus appears relevant to the classification of late-onset, seronegative rhumatisms.
 ...
PMID:[Seronegative rheumatism of late onset. Incidence and atypical forms of spondylarthropathy]. 177 4

We describe a 24-year-old man who developed reactive arthritis (ReA) after a dysenteric illness caused by Salmonella hadar. Serologic tests suggested recent exposure of family members to Salmonella. All members of the family were HLA-B27 positive, but no other family member developed acute ReA, although 2 of them had clinical evidence of previously existing B27 associated arthritis.
 ...
PMID:Interplay of microbe and major histocompatibility complex: a family study. 178 3

One hundred and fourteen patients with acute anterior uveitis were studied for the presence of the HLA-B27 tissue type, the prevalence of spondylitis and arthritis and the occurrence of gastro-intestinal and urogenital infections or diarrhoeal illness in the history. Eighty-seven (76%) were B27+ and 27 (24%) B27-. Forty-two (48%) of the B27+ group had ankylosing spondylitis (AS); 13 (30%) of them were females. Sacroilitis (SI) with no spinal involvement was present in 21 patients (24%), 13 (61%) males and 8 (38%) females. Peripheral arthritis occurred in 6 patients. Thus, 68 (78%) of the HLA-B27+ positive patients had inflammatory spinal and/or joint disease, compared with 1 (4%) of the HLA-B27- group (p less than 0.001). The AS diagnosis was unknown previous to our examination in 31% of the males and 54% of the females, and SI was undiscovered in 61% of the males and 62% of the females. The occurrence of acute enteric infections was significantly increased in the B27+ AAU group, compared with the B27- patients and the patients reported exacerbation of AAU in connection with episodes of diarrhoea. An increased occurrence of urogenital infections was shown only in co-comparison with the males of the B-27+ AAU group. Thirty-three out of 47 AAU patients assayed by enzyme immuno-assay (EIA) for the quantification of IgM, IgA and IgG antibodies against Klebsiella pneumoniae, E coli, and Proteus mirabilis had significantly raised antibody titres against one or more of the antibodies studied, as compared to 62 healthy controls.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Acute anterior uveitis, arthritides and enteric antigens. 180 94

Among a group of children hospitalized for "joint pain", four of the cases of reactive arthritis were due to Yersinia infection. These four cases are described. Some patients had suggestive clinical symptoms but serologic studies were needed to establish the diagnosis. Tissue group studies showed that two children were HLA B27 and one was HLA B7. Reactive arthritis due to Yersinia in a form of "enteral arthritis". The prevalence of Yersinia arthritis has not been documented. Serologic tests are essential to outrule the main differential diagnosis, i.e. chronic juvenile arthritis (juvenile rheumatoid arthritis). Short-term resolution of symptoms is seen in every case. The long-term outcome is less well documented, especially with regard to the risk of recurrence and to relationships with peripheral joint disease and spondylarthropathies of early adulthood. HLA B27 positivity may be a risk factor. The pathogenesis of Yersinia-induced reactive arthritis is unclear; current studies are focusing on immunologic factors. The uncertainties concerning long-term outcome justifies renewed interest in childhood reactive arthritis.
 ...
PMID:[Reactive arthritis caused by Yersinia in children. Report of 4 cases]. 187 25

Altogether 52 children suffering from reactive arthritis were placed under observation. In 45 patients arthritis developed after nasopharyngeal infection and was marked by a favourable course with a rapid positive dynamics. 7 children with a history of intestinal infection manifested Reiter's syndrome; in these children arthritis was characterized by a grave and prolonged course and by a high laboratory activity. HLA A10 (RR = 2.7), B27 (RR = 2.5) and DR2 (RR = 2.19) antigen were detected significantly more frequently in ReA patients who suffered nasopharyngeal infection. In children with Reiter's syndrome, the genetic markers of predisposition to the disease were HLA A10 (RR = 5.93) and B27 (RR = 149.1) antigens.
 ...
PMID:[The clinical and immunogenetic characteristics of reactive arthritis in children]. 188 5

Evolution of polyarthritis was elucidated in 115 patients with Reiter's syndrome. There were 67% of men and 33% of women. The mean age of the patients was 33 years. 57% of the patients were HLA B27 carriers. In 70% of the patients, arthritis ran an acute course, in 12%, a subacute course, and 18% developed chronic arthritis. The axial skeleton was involved in 1/3 of the test subjects, enteropathies of different localization were detected in 58% of the cases. The author failed to establish criteria for predicting arthritis chronicity.
 ...
PMID:[The evolution of the articular lesion in Reiter's syndrome]. 188 13

The influence of HLA-B27 antigen on clinical, radiological and laboratory features of rheumatoid arthritis (RA) was studied. The group with B27 antigen comprised: 4 males and 20 females aged 28 to 71 and a group of patients free from B27 antigen consisted of 2 males and 21 females aged 26 to 69. RA patients possessing the B27 antigen did not differ regarding the age of the onset of disease, the distribution of affected joints during the follow-up (3-10 years), the development stages of the disease and the presence of rheumatoid factor when compared with B27 negative RA patients. The arthritis of the radiocarpal joints (p less than 0.01) was significantly more often the first sign of the disease in patients with B27 antigen. In these patients low back pain and morning stiffness in the low back were twice as frequent as they were in patients not possessing this antigen. The clinical pattern of the affected spine was also found more frequently in B27 carriers (p less than 0.05). B27 positive RA patients showed also the clinical pattern of sacroiliitis (SI) (p less than 0.05) and x-ray SI (p less than 0.01) significantly more often than the patients free from this antigen. In addition, symmetric arthritis of the peripheral joints was more often diagnosed in patients free from B27 antigen.
 ...
PMID:HLA-B27 antigen and rheumatoid arthritis. 195 Jun 38

The Second International Simmons Center Conference on HLA-B27-Related Disorders presented a number of new observations related to the molecular biology of the HLA-B27 molecule, its functional biology as a peptide-binding molecule, and the clinical implications of the association of B27 with the spondylarthropathies, as well as new clinical information concerning these diseases. As a result of the rapid developments in these fields, new insights into the pathogenesis of the B27-related spondylarthropathies will emerge.
Arthritis Rheum 1991 Nov
PMID:The Second International Simmons Center Conference on HLA-B27-Related Disorders. 159 28

Three more cases of B27-positive patients who developed peripheral arthritis immediately after trauma are reported. The first had an exacerbation of arthritis in the right hip after falling from her motor-bike. The second had arthritis of the distal interphalangeal (DIP) joint of the right forefinger after shutting his finger in the door of his car. The third had arthritis of the right sternoclavicular joint after a road-accident while fastening her safety belt.
 ...
PMID:The triggering role of physical injury in the onset of peripheral arthritis in seronegative spondyloarthropathy. 204 84

The diagnosis of spondylarthropathy is more difficult in children than in adults because there are no uniform diagnostic criteria. In a study involving 65 children (20 girls and 45 boys) with chronic arthritis and HLA B27 antigen, the clinical symptoms, localization and type of joint involvement, the extraarticular manifestations and radiology results are analyzed. In 73% of cases the joints affected were located in the lower extremities. In 30% of the patients an enthesopathy was present. Four patients had psoriasis and 9 intestinal symptoms. In no patient were autoantibodies detected. In one half of the cases there was evidence of a familial disposition. With the help of two different systems of classification an attempt is made to evaluate the individual criteria and propose guidelines for diagnosis. The results so far have shown that both systems are applicable to children.
 ...
PMID:[Spondyloarthropathies in children]. 204 21


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>