Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003864 (arthritis)
 69,039 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report an original form of chronic inflammatory arthritis in 14 young adults, mainly females: an oligoarthritis with antinuclear antibodies. A first group of 10 patients, 9 females and one male, over 17 year-old, mean age 25, presented with monoarthritis or oligoarthritis of the knees, and less frequently of the wrist or elbow. Arthritis was chronic, recurrent, not destructive nor incapacitating. Rheumatoid factor was absent, and the only biologic abnormality was positive ANA at a significant rate. No patient was typed for HLA DR5. No other clinical or biological symptom appeared during a mean follow-up period of 5.5 years (6 mo-30 yrs). The patients have been totally free of any ocular symptoms. The benignity of the disease and its good prognosis must be underlined. Another group of 4 adult women had a similar inflammatory disease, which started during childhood: the biological and clinical spectrum was found quite similar in both groups, except for uveitis which occurred only in the later. Most subsets of juvenile arthritis have counterpart in adulthood, except for the pauciarticular subset with AAN. The cases herein described could fill the gap, the only difference with the juvenile onset form being the absence of uveitis. Thus, even if our observations of oligoarthritis with ANA in young women are the equivalent of the pauciarticular form in young girls, ocular involvement remains specific of childhood.
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PMID:[Adult oligoarthritis with antinuclear factors. A new syndrome, relations with juvenile oligoarthritis]. 187 14

Methotrexate therapy was evaluated in 30 children with juvenile chronic arthritis according to the type of onset. The systemic form seemed less responsive than the ANA positive form with a polyarticular course or polyarticular onset. The clinical improvement, particularly in the ANA positive polyarticular course was confirmed by a significant decrease in the values of the ESR. Side effects occurred in 12 patients and consisted of gastrointestinal upset, mouth ulcers, slight leucopenia and elevated transaminases. They led to discontinuation of the treatment in only one child. Concomitant therapy could be stopped in 50% of the patients with an ANA positive polyarticular course, but remained necessary in the two other groups. These results indicate a differential effect of MTX therapy according to the type of JCA.
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PMID:Evaluation of methotrexate in the treatment of juvenile chronic arthritis according to the subtype. 187 91

Keratoconjunctivitis sicca patients diagnosed on the basis of a history, dry-eye symptoms, and definite clinical signs of keratoconjunctivitis sicca, with the associated symptoms of dry mouth and/or arthritis, had measurements of tear osmolarity, Schirmer tear test without anesthetic, stimulated parotid salivary flow, and serum analysis for the presence of autoantibodies associated with Sjogren's Syndrome. In contrast to previous studies, a lower incidence of SS-A or SS-B (1-3%), ANA (41-47%), DNA (11-16%), and RF (9-12%) serum antibodies was detected. Salivary-stimulated parotid flow was abnormally decreased in 59% of the patients. Sjogren's syndrome, as indicated by the presence of serum antibodies, appears to have a lower incidence in keratoconjunctivitis sicca than considered previously.
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PMID:Sjogren's syndrome and keratoconjunctivitis sicca. 205 25

The diagnosis of JAS in 19 of the 24 patients with oligo-articular and the polyarticular subtypes of JRA established primarily was reexamined. Coexistence of JAS and rheumatoid arthritis was found in 4 of the 19 patients with JAS. Of the 19 patients with JAS, 18 were male and 1 was female. The mean age of onset of the disease was 12.6 years (ranging from 8 to 16). Peripheral arthritis was the first symptom in all the 19 patients, predominantly in the joints of knee, hip and ankle. 69% of the 13 patients with hip involvement developed deformity. Twelve patients had lumbosacral pain. Arthritis occurred in 7 of the 19. There was X-ray evidence of sacroilitis in all the JAS patients. In 3 of the 19 patients' families, all the family members had ankylosing spondylitis. Laboratory investigations confirmed the presence of HLA-B27 and absence of RF and ANA in these 19 patients. The study shows that early findings of JAS are not easy to distinguish from those of JRA and that the diagnosis of JAS should be considered for a boy of teenage with chronic arthritis.
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PMID:[Juvenile ankylosing spondylitis (JAS) and juvenile rheumatoid arthritis (JRA)]. 209 54

A review of the history, production, characterics and availability of the standards and reference preparations in the field of ANA determination is given. For ANA of the homogeneous type and for anti-DNA standard reagents are recognized by the WHO. This enables the expression of quantitative results in international units, leading to a decrease of interlaboratory variations. For the other types of nuclear fluorescence and for anti-Sm, anti-Ro (SS-A), anti-La (SS-B), anti-Scl 70 and anti-Jo-1, reference reagents are made available by the Arthritis Foundation (AF) and the Centers for Disease Control (CDC) in the USA. For anti-nRNP, a WHO reference reagent exists. The use of the above materials is advocated. Requests for WHO standards should be directed to: Dept. of Reagents CLB, P.O. Box 9190, 1006 AD Amsterdam, The Netherlands, and for AF/CDC reagents to: AF/CDC ANA Ref. Lab., Immunology 1 - 1202 A 25, CDC, Atlanta GA 30333, USA.
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PMID:Standards for ANA and anti-DNA. 211 38

Serum interferon levels were estimated in 67 samples obtained from 47 patients with SLE. Levels were increased in 70% of the samples and 72% of the patients. In the patients with active disease 81% had increased interferon levels, while in the group with clinically quiescent disease 10% had increased levels. In 20 patients retested 3 1/2 months after treatment the changes in interferon levels tended to parallel the changes in clinical disease activity in 80% of cases. Patients with active skin lesions, arthritis, and renal or haematopoietic involvement tended especially to have increased interferon levels. Interferon levels were directly related to ANA titre and inversely related to serum C3 levels, but not related to serum levels of circulating immune complexes or immunoglobulin. The interferon was shown to be of type alpha. The interferon level can be regarded as one of several parameters reflecting disease activity and may also be related to the prognosis. As it is possible that interferon may be a direct mediator of the pathophysiology of auto-immune disease, we do not recommend the use of interferon or its inducers in the therapy of SLE.
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PMID:Serum interferon in systemic lupus erythematosus. 244 58

An effort was made to get a clear understanding of antilupus pill (ALP) action on systemic lupus erythematosus (SLE) and to evaluate its therapeutic effect. ALP was originated from a notable efficacious recipe by an expert physician of TCM. It was prepared with the decoction of 17 Chinese medical herbs (such as Flos Lonicerae, Salvia miltiorrhiza etc.) to dispell noxious heat from blood, replenish the vital essence, invigorate blood circulation and resolve the stagnation. The effective rate of 92% for 230 SLE patients treated with ALP and corticosteroids, 85% for 76 patients treated with ALP alone, 79-89% for rash, trichomadesis, oral or nasal pharynx ulcer patients, and arthritis patients without deformation were obtained. The ANA titer was decreased markedly for 75% patients. ALP had no side effect and could take the part place of hormone in dosage and lessen its side effect. Through pharmacological verification it was concluded that ALP could inhibit the inflammatory process from various causes including type I, III and IV hypersensitivity, and show no response on both sensitizing and reactive stages of immunological reaction.
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PMID:[Clinical and laboratory studies of the effect of an antilupus pill on systemic lupus erythematosus]. 259 47

15 cases of subacute cutaneous lupus erythematosus are reported. The diagnosis was based on the presence of the typical clinical features, on the histologic and immunpathologic examination of lesional skin and on the characteristic laboratory findings. 8 patients had annular type, 4 patients had papulosquamosus type of the characteristic skin signs of subacute cutaneous lupus erythematosus. In 3 patients both types of lesions existed simultaneously. 5 patients fulfilled the American Rheumatism Association criteria for systemic lupus erythematosus, however the systemic symptoms (arthritis, arthralgia, fever, myalgia, photosensitivity) were mild. 4 patients had positive ANA test, anti-Ro/SSA antibodies were determined in 5 patients, anti-RNP antibodies were detected in 8 patients. Anti-dsDNA antibodies were not detected. Subacute cutaneous lupus erythematosus is an intermediate subset in severity between discoid lupus erythematosus and severe systemic lupus erythematosus, therefore a milder form of therapy should be chosen.
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PMID:[Subacute cutaneous lupus erythematosus based on a study of 15 cases]. 268 50

A 16-year-old girl meeting the criteria for SLE is described. Salient features of the clinical course included active glomerulonephritis with dense subepithelial deposits on electron microscopy, pulmonary embolism, axillary vein thrombosis, arthritis, serositis and fever. Disease activity correlated with the presence of lupus anticoagulant as measured by VDRL and partial thromboplastin time (PTT). Her serum was consistently negative to ANA, anti-DS-DNA, anti-SS-DNA, ENA, anti-Ro, anti-La, and LE cells for the entire 4-year course. She responded remarkably to prednisone and azathioprine. Reappearance of VDRL and elevated PTT preceded exacerbation of disease activity and served as a serological guide for modifying medical treatment.
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PMID:Antinuclear antibody-negative systemic lupus erythematosus (SLE) and severe renal involvement: close correlation between disease activity and appearance of circulating anticoagulant. 312 93

Iridocyclitis is a common complication of juvenile rheumatoid arthritis. It affects particularly female patients with mono-oligoarthritis. A positivity of ANA-test is usually observed, representing a marker for the disease. The course is chronic, leading potentially to scarring and blindness. The insidious onset, often not parallel to arthritis, requires careful ophthalmologic examination of all patients at risk, in order to achieve early diagnosis and treatment.
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PMID:[Iridocyclitis and juvenile rheumatoid arthritis]. 332 56


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