Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003864 (arthritis)
 69,039 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Juvenile idiopathic arthritis is a heterogeneous group of diseases characterised by arthritis of unknown origin with onset before age of 16 years. Pivotal studies in the past 5 years have led to substantial progress in various areas, ranging from disease classification to new treatments. Gene expression profiling studies have identified different immune mechanisms in distinct subtypes of the disease, and can help to redefine disease classification criteria. Moreover, immunological studies have shown that systemic juvenile idiopathic arthritis is an acquired autoinflammatory disease, and have led to successful studies of both interleukin-1 and interleukin-6 blockade. In other forms of the disease, synovial inflammation is the consequence of a disturbed balance between proinflammatory effector cells (such as T-helper-17 cells), and anti-inflammatory regulatory cells (such as FOXP3-positive regulatory T cells). Moreover, specific soluble biomarkers (S100 proteins) can guide individual treatment. Altogether these new developments in genetics, immunology, and imaging are instrumental to better define, classify, and treat patients with juvenile idiopathic arthritis.
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PMID:Juvenile idiopathic arthritis. 2168 84

Falls in community-dwelling older adults are a complicated phenomenon that are attributed to sociodemographic characteristics, health conditions, functional problems, and environmental factors. The current cross-sectional and correlational study aimed to explore comprehensive risk factors for falls in community-dwelling older adults using a nationally representative data file (N = 5,930). Descriptive statistics were used and multiple logistic regression analyses were performed. Study findings showed that homebound or semi-homebound older adults were 50% more likely to experience a fall than non-homebound individuals. Impaired balance was the strongest predictor (odds ratio [OR] = 2.37, p < 0.001), followed by problems moving around in the home. Arthritis (OR = 1.39, p = 0.009) and depression or anxiety (OR = 1.28, p = 0.013) were additional risk factors. Community health or home health nurses need to assess these risk factors when planning fall intervention programs for older adults using evidence-based prevention strategies. [Journal of Gerontological Nursing, 44(10), 40-48.].
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PMID:A Comprehensive Assessment of Risk Factors for Falls in Community-Dwelling Older Adults. 3025 23