Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003864 (arthritis)
 69,039 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We provide estimates of the prevalence, incidence and remission of difficult bladder emptying symptoms (prostatism) among noninstitutionalized men 60 years old and older living in a community in the United States. The prevalence of 1 or more symptoms of prostatism (hesitancy, straining, weak stream, intermittency or use of a catheter) among men who never had prostatic surgery is 35%. The annual incidence rates during years 1 and 2 of followup were 16.4% and 16.1%, respectively. Remission of symptoms of prostatism also was observed. Of the respondents with severe symptoms at baseline 22.9% were asymptomatic 1 year later. The prevalence of prostatic surgery in this population was 20%. The annual incidence rates during years 1 and 2 of followup were 2.6% and 3.3%, respectively. Urological and nonurological correlates of prostatism are identified. The irritative bladder symptoms are all significantly associated with moderate to severe bladder emptying symptoms (p < 0.0005). Nonurological conditions that also are associated with moderate to severe symptoms of prostatism include use of sedatives or tranquilizers, arthritis, poor health status and transient ischemic attacks. These observations are the initial step in documenting and understanding the various symptoms of prostatism, and its application in clinical practice.
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PMID:Epidemiology of bladder emptying symptoms in elderly men. 127 23

Of 1042 individuals aged 65 years and over who were successfully interviewed in a community survey of health and physical activity, 35% (n = 356) reported one or more falls in the preceding year. Although the overall ratio of female fallers to male fallers was 2.7:1, this ratio approached unity with advancing age. Mobility was significantly impaired in those reporting falls. Asked to provide a reason for their falls, 53% reported tripping, 8% dizziness and 6% reported blackouts. A further 19% were unable to give a reason. There was no association between falls and the use of diuretics, antihypertensives or tranquilizers, but a significant association between falls and the use of hypnotics and antidepressants was found. Discriminant analysis of selected medical and anthropometric variables indicated that handgrip strength in the dominant hand and reported symptoms of arthritis, giddiness and foot difficulties were most influential in predicting reports of recent falls.
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PMID:Falls by elderly people at home: prevalence and associated factors. 326 40

A mail survey of 1,650 elderly consumers evaluated prescription drug leaflets for antihypertensives, tranquilizers, and arthritis medicines. Of those who said they received the leaflet, 95 per cent read it, 76 per cent kept it, and 56 per cent discussed it with another person. Respondents taking antihypertensive medicine were more apt to keep the leaflet and say they learned new information from it. Those taking tranquilizers were less likely to say the leaflet made them feel better about using the drug.
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PMID:Utility of drug leaflets for elderly consumers. 669 30

The decoction of the leaves of Nyctanthes arbor tristis Linn. (Harsingar) is widely used in Ayurvedic system of medicine for the treatment of sciatica, arthritis, fevers, various painful conditions and as laxative. In the present investigation, the water soluble portion of the alcoholic extract of the leaves was screened for some CNS activities (viz. hypnotic, tranquilizing, local anaesthetic, hypothermic, anticonvulsant), antihistaminic and purgative activities. The extract produced general depression of spontaneous motor activity, significantly increased pentobarbitone sleeping time though it had no effect on righting reflex. Furthermore higher doses of the extract abolished CAR without affecting motor coordination. Moreover the extract exhibited hypothermic effect and protected guinea pigs from histamine aerosol. These activities are common to major tranquilizers and support the usage of the plant by Ayurvedic physicians in aforementioned conditions. In addition significant purgative activity was also exhibited by the extract.
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PMID:Tranquilizing, antihistaminic and purgative activity of Nyctanthes arbor tristis leaf extract. 1212 32

Several species of Ferula genus have been used in folk medicine in digestive disorders, rheumatism, headache, arthritis, and as tranquilizers, antispasmodic and aphrodisiac. From the dry and powdered roots of Ferula hermonis Boiss was extracted the oxygenated sesquiterpene 1,5-trans-daucane type: ferutinine (1). The structure of (1) was established by spectroscopic methods as: IR, (1)H RMN, (13)C RMN, COSY, HMBC, HMQC, NOESY, EIMS, and CIMS. The possible signaling pathway of ferutinin (1) in nervous tissue in vitro was assessed and the results showed that this compound is able to increase nitric oxide synthase activity and inositol monophosphate accumulation (49%, each) in the median eminence of the rat brain, suggesting that compound (1) is associated to the activation of phosphoinositide breakdown and nitric oxide production (NO), the last is a gaseous intercellular messenger known to play a broad role in human biology from homeostasis to pathology.
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PMID:Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat. 1657 58

Purpose: To investigate dry eye-associated risk factors in a hospital-based population of China.Methods: It is a multi-center cross-sectional study involving 94 tertiary hospitals all over China. Outpatients in these hospitals were asked to complete McMonnies Questionnaire and undergo dry eye examinations. A total of 31124 participants were finally selected.Results: Of the 31124 participants, 17937 (57.6%) participants were clinically diagnosed as dry eye. The percentage of diagnosed dry eye was higher among women than among men (61.9% versus 53.2%). Dry eye was diagnosed more often with higher age (under 25 years, 47.6%; 25-45 years, 56.6%; over 45 years, 65.6%). In multivariate analysis, independent risk factors for dry eye were female sex (odds ratio [OR] = 1.44; 95% confidence interval [CI], 1.37-1.51), higher age (compared to age<25 years, 25-45 years: OR = 1.42; 95%CI, 1.34-1.51; compared to age<25 years, over 45 years: OR = 2.09; 95%CI, 1.96-2.24), arthritis (OR = 1.51; 95%CI, 1.38-1.65), thyroid diseases (OR = 1.41; 95%CI, 1.27-1.56), refractive surgery (OR = 1.23; 95%CI, 1.15-1.31), antihistamine eye drops (OR = 1.34; 95%CI, 1.23-1.47), diuretics (OR = 1.13; 95%CI, 1.01-1.27), sleeping tablets (OR = 1.21; 95%CI, 1.09-1.34), tranquilizers (OR = 1.60; 95%CI, 1.40-1.82), medication for duodenal ulcer (OR = 1.88; 95%CI, 1.61-2.21) and medication for digestive problems (OR = 1.14; 95%CI, 1.05-1.25). Diabetes was not found to be significantly associated with dry eye in multivariate model (p = .836).Conclusions: Dry eye was commonly diagnosed among ophthalmic outpatients in mainland China. Risk factors for dry eye included female sex, higher age, certain systemic diseases and use of certain medications (see above). Diabetes was not significantly associated with dry eye in this study.
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PMID:Risk Factors for Dry Eye in Mainland China: A Multi-Center Cross-Sectional Hospital-Based Study. 3121 6