Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003864 (arthritis)
 69,039 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Interleukin-6 (IL-6), also called 26-kd protein, hybridoma plasmacytoma growth factor, beta 2-interferon, or B cell stimulatory factor 2, is a recently described human cytokine with multiple growth and differentiation activities. Using a very sensitive bioassay based on the growth factor activity of this protein for B cell hybridomas, we found that IL-6 activity was significantly elevated in synovial fluid from patients with rheumatoid arthritis (RA) or other inflammatory arthritides, as compared with that in a group of patients with osteoarthritis. Moreover, IL-6 was detected in about one-third of the serum samples from patients with RA. In the latter group, we found a significant correlation between serum IL-6 activity and serum levels of C-reactive protein, alpha 1-acid glycoprotein, alpha 1-antitrypsin, fibrinogen, and haptoglobin, which indicates that IL-6 is related to disease activity in patients with RA.
Arthritis Rheum 1988 Jun
PMID:Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. 326 Jan 2

High-dose leucovorin (folinic acid) supplementation was tested in a prospective, unblinded manner for 4 weeks in 7 rheumatoid arthritis patients who were being treated successfully with low-dose methotrexate (MTX). Nausea caused by MTX disappeared; however, the underlying rheumatic disease worsened in all patients. Subjective clinical assessment, Ritchie articular index, grip strength, erythrocyte sedimentation rate, and levels of C-reactive protein showed statistically significant deterioration. All these parameters improved after the leucovorin was stopped. This is the first direct clinical evidence implying folate antagonism in the action of low-dose MTX therapy in rheumatoid arthritis patients.
Arthritis Rheum 1988 Jul
PMID:The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients. 326 Jul 83

Serum and synovial fluid (SF) levels of serum amyloid A (SAA) and C-reactive protein (CRP) were measured in 46 cases of various inflammatory arthritis (Group 1), and in 40 cases of noninflammatory arthritis: 18 cases of osteoarthritis (Group 2) and 22 cases of traumatic arthritis (Group 3). Serum and SF SAA levels were markedly elevated in Group 1: 126.4 micrograms/ml +/- 19.2 SEM and 46.4 micrograms/ml +/- 10.5 SEM, respectively; moderately elevated in Group 2: 10.1 micrograms/ml +/- 2.9 SEM, 4.0 micrograms/ml +/- 1.1 SEM and moderately elevated in Group 3: 10.4 micrograms/ml +/- 1.2 SEM, 4.0 micrograms/ml +/- 1.2 SEM, respectively. Serum/SF SAA ratios were similar in all 3 groups and ranged between 2.52-2.72. In comparison to SAA, the increment of serum and SF CRP above normal levels was moderate. A positive strong correlation was found between serum SAA and serum CRP: r = 0.64 (p less than 0.001) and between SF SAA and SF CRP: r = 0.59 (p less than 0.0001). SF SAA did not correlate with the number of SF white blood cells but did correlate with the percent of SF polymorphonuclear cells: r = 0.23 (p less than 0.05).
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PMID:Serum and synovial fluid levels of serum amyloid A protein and C-reactive protein in inflammatory and noninflammatory arthritis. 341 44

To develop a scheme for primary diagnosis, we analyzed the clinical findings and laboratory test results in 278 children with arthritis by using univariate analysis and multivariate logistic regression analysis. An elevated C-reactive protein (CRP) value, a temperature above 38.5 degrees C, and a high white blood cell count were independent predictors for the diagnosis of septic joint infection in patients with acute monoarthritis. The presence of either of the first two signs had a sensitivity of 100% and a specificity of 87% for septic arthritis. Sixty-seven percent of all patients with arthritis were cured within two weeks from the onset of joint symptoms. In patients whose disease duration exceeded two weeks, a low CRP value, the absence of fever, and an elevated IgG value were independent predictors for the diagnosis of juvenile arthritis. Antinuclear antibodies had a specificity of 100% and a sensitivity of 25% for juvenile arthritis or other connective tissue diseases. We recommend that laboratory tests indicated for all children with joint symptoms include determinations of the erythrocyte sedimentation rate and the CRP value, both total and differential leukocyte counts, urinalysis, and a bacterial culture of a throat smear. When arthritis is prolonged or when enteroarthritis is suspected, tests for antinuclear antibodies and serum immunoglobulins, serologic tests for Yersinia and Salmonella, and stool bacterial cultures should be included.
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PMID:Clinical signs and laboratory tests in the differential diagnosis of arthritis in children. 349 37

Of 452 patients with brucellosis, 169 (111 male and 58 female) had osteoarticular complications. Brucella melitensis was isolated from the blood in 7.7% of the cases. Fever, chills, arthralgia, backache, high levels of C-reactive protein, positive rheumatoid factor, and splenomegaly were more frequent in osteoarticular brucellosis than in nonosteoarticular disease. Arthritis occurred in the hip joint in 90 cases (53%), knees in 61 (36%), sacroiliacs in 33 (20%), ankles in 25 (15%), elbows in nine (5.3%), shoulders in eight (5%), wrists in six (3.5%), and sternoclavicular arthritis occurred in three cases (1.8%). Spondylitis occurred in 10 cases (6%), osteomyelitis in four (2.4%), and tendinitis or bursitis in two (1.2%). Treatment with tetracycline or trimethoprim-sulfamethoxazole (TMP-SMZ) alone (four to eight weeks) or in combination with streptomycin (two to four weeks) resulted in a relapse rate of 16.6%. No relapses occurred in seven patients treated with repeated four- to six-weeks courses of rifampin plus tetracycline or TMP-SMZ plus streptomycin.
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PMID:Osteoarticular complications of brucellosis: a study of 169 cases. 349 50

Because synovial fluid levels of the C3 anaphylatoxins, C3a and C3a desArg, are more than 7 times higher in patients with rheumatoid arthritis (RA) than in patients with degenerative joint disease or traumatic arthritis, we conducted a prospective study of plasma levels of C3 and C5 anaphylatoxins in 11 RA patients. The mean level of C3 anaphylatoxin in 37 RA plasma specimens was twice as high as that in samples obtained from 9 normal volunteers (272.9 +/- 106.1 ng/ml versus 133.9 +/- 19.4 ng/ml) (P less than 0.05). We found that the joint index and the disease activity index were correlated with the plasma C3 anaphylatoxin level, and that the correlation values were similar to those for serum C-reactive protein level and for the Westergren erythrocyte sedimentation rate. In correlations of the joint index and disease activity index with combinations of laboratory test results, the plasma C3a level, the serum C-reactive protein level, and the erythrocyte sedimentation rate, we found that almost any pair of laboratory tests correlated more strongly than did any one test.
Arthritis Rheum 1987 Oct
PMID:Elevated plasma C3 anaphylatoxin levels in rheumatoid arthritis patients. 349 7

Ninety-three patients with Crohn's disease who had not undergone bowel resection at the time of diagnosis (during the years 1969-1983) were selected for the study, to elucidate whether initial anatomical involvement correlates with clinical manifestations, complications, laboratory findings, and prognosis. Forty-one patients had isolated small intestine disease (44%), 37 ileocolic (40%), 13 colonic disease alone (14%), and two rectal or appendix involvement (2%). Statistically significant symptoms were fever and rectal bleeding with colon involvement, and number of liquid or very soft stools in 1 week with ileocolic or colon involvement. Statistically significant complications included intestinal obstruction with ileocolic disease, perianal fistulas, and arthritis with colonic disease. Increases in ESR, C-reactive protein, and white blood cell in patients with colon involvement were among the statistically significant laboratory findings. Gammaglobulin was significantly higher in patients with ileocolic or colon involvement than in those with small intestine disease. Red cell count and hemoglobin were significantly lower in patients with ileocolitis than in patients with small intestine involvement. Crohn's disease activity index (CDAI) was significantly higher in patients with ileocolic or colon involvement than in those with small intestine involvement only. These findings confirm that colonic involvement renders the disease more severe than involvement of the small intestine. Surgery was required for 22 patients (24%) during a 2.8-year follow-up, but the difference among the three groups was not significant.
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PMID:Anatomical involvement and clinical features in 91 Japanese patients with Crohn's disease. 357 91

We evaluated the clinical usefulness of determinations of alpha 1-acid glycoprotein microheterogeneity patterns in distinguishing patients who have active systemic lupus erythematosus (SLE) from those who have SLE with intercurrent infection. We used agarose affinity electrophoresis with concanavalin A (Con A) as a ligand. Results were expressed as reactivity coefficients (RC), which are the ratios of variants reactive with Con A to the variants not reactive with Con A. No significant differences were found between the mean RC (+/- SD) in healthy individuals (1.35 +/- 0.26) and that in patients with various degrees of SLE activity. In contrast, a significantly higher mean RC was found in sera from patients with intercurrent infection (2.70 +/- 0.76) compared with each of the other groups studied (P less than 0.001). An RC greater than 2.25 was found in none of 42 sera from patients without infection and in 15 of 18 sera from patients with infection (sensitivity 83%, specificity 100%). C-reactive protein (CRP) levels were also significantly higher in SLE patients with intercurrent infection than in patients with very active disease (P less than 0.05). Levels of CRP greater than 60 mg/liter were found in 3 of 42 SLE patients without infection and in 8 of 18 patients with infection (sensitivity 39%, specificity 93%). The results show that in SLE patients, the finding of a relative increase in Con A-bound serum alpha 1-acid glycoprotein is a more sensitive indicator of intercurrent infection than is the finding of increased levels of CRP.
Arthritis Rheum 1987 May
PMID:Microheterogeneity of alpha 1-acid glycoprotein in the detection of intercurrent infection in systemic lupus erythematosus. 359 35

A new isolation procedure of rat C-reactive protein (CRP) by affinity chromatography on amino-coupled phosphorylcolamine-Sepharose is described. CRP serum level of rats injured by turpentine injection or two different arthritis models was determined to test the potency of this protein as an marker of inflammation. The influence of repeated administration of carbon tetrachloride as a hepatotoxic agent was investigated in the same way. It was shown that CRP determination is a useful method to observe the course of experimental inflammations and other tissue injuries as well.
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PMID:The rat C-reactive protein--isolation and response to experimental inflammation and tissue damage. 363 Aug 61

Psoriatic arthritis (PA) may respond to disease-modifying antirheumatic therapy. The value of assessing disease activity with indices devised for rheumatoid arthritis (RA) was investigated in 72 patients with seronegative PA. Thirty patients had a peripheral polyarthritis including the distal interphalangeal joints (DIPJs) and 15 a symmetrical arthritis sparing DIPJs (RA-like). Significant correlations (Spearman rank test) were seen between the clinical variables (pain score, grip strength, Ritchie articular index and a summated index of disease activity) in these two groups. Ten patients with a markedly asymmetrical arthritis showed a poor correlation between clinical variables. Although the objective indices - erythrocyte sedimentation rate (ESR) and C-reactive protein - correlated together in the first two groups, the ESR correlated solely with clinical indices, and then only in RA-like patients. These results cast some doubt on the value of assessment methods based on RA when evaluating subgroups of PA other than RA-like disease.
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PMID:Indices of disease activity in psoriatic arthritis. 368 69


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