Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003864 (arthritis)
 69,039 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Groups of patients with different forms of infection with Haemophilus influenzae type B (Hib), namely meningitis, epiglottitis, arthritis, and periorbital cellulitis, were evaluated for the appearance of serum IgG, IgA, IgM, and nasopharyngeal secretory (NPS) IgA (SIgA) antibody response to Hib capsular antigen at various intervals after the onset of clinical illness, by using an indirect enzyme-linked immunosorbent assay. The serum immune response was characterized by its predictable absence in infants under 23 mo of age, and in those with meningitis who, regardless of age, had high levels of circulating antigen. On the other hand, antibody response was frequently detected in the serum of older infants. Significantly, however, the appearance of SIgA antibody was demonstrated in virtually all patients with Hib infections under 23 mo of age. In addition, a positive correlation was observed between the concentration of antigen NPS, the level of SIgA activity in the NPS, and the absence of antibody response in the serum. These observations are strikingly similar to the development of systemic hyporesponsiveness (oral tolerance) observed after oral administration of certain infectious or nonreplicating antigens in experimental animals. It is suggested that similar mechanisms may underlie the immunologic abnormalities observed in the serum antibody response in infants with Hib meningitis.
 ...
PMID:Development of respiratory mucosal tolerance during Haemophilus influenzae type B infection in infancy. 660 87

A total of 813 patients from the years 1976 to 1980 who had a bacteremic Haemophilus influenzae infection were analyzed. Special attention was paid to disease entities (16.5% of the total) other than meningitis (60.5%) or epiglottitis (23.0%). Ninety-six cases in the nonmeningitis, nonepiglottitis (NMNE) group showed the following distribution: 25 patients with septicemia without specific focus, 21 arthritis, 19 cellulitis, 17 pneumonia, six otitis, four local abscess, two laryngotracheobronchitis, and two with an eye infection. Eighty-eight percent of the cases were children who were less than 5 years old; in the septicemia and pneumonia groups, however, 33 percent were 15 years of age and older, and 10 percent were over 60 years of age. All diseases in the NMNE group were acute; 51 percent of the patients sought medical advice within two days. C-reactive protein (CRP) was elevated constantly at presentation, erythrocyte sedimentation rate (ESR) was increased (greater than 20 mm/hr) in 87 percent, high fever greater than 38.5 degrees C (101.3 degrees F) was measured in 85 percent, and leukocytosis (greater than 15 X 10(9)/l) was present in 71 percent. Various antimicrobial agents were given for an average of 17 days. The mean period of hospitalization was 13 days. Case fatality rate was 4 percent; all deaths occurred among patients with an underlying disease. No permanent damage was observed.
 ...
PMID:Systemic Haemophilus influenzae infection in Finland. 670 35

Clinical manifestations and epidemiologic characteristics of 117 cases (31 children and 86 adults) of Lyme disease in New Jersey from 1978 to 1982 are summarized. The male-female sex ratio was 1.9:1. An endemic focus in Monmouth County has been recognized. Erythema chronicum migrans was present in 93% of cases and was the only clinical manifestation in 25% of patients. Nonspecific febrile syndrome, in addition to erythema chronicum migrans, was present in 45% of cases; 26% had arthritis. The proportion of cases with arthritis in 1982 (7/56) was less than for 1978 to 1981 (24/61) probably because of better recognition of milder cases by physicians and earlier antibiotic treatment, which may have reduced late complications. Meningitis (10%) and cranial nerve palsies (8%) were the most frequent neurological manifestations. As medical personnel and the public become more aware of the disease, Lyme disease is being recognized with increased frequency in central and southern New Jersey.
 ...
PMID:Clinical manifestations and descriptive epidemiology of Lyme disease in New Jersey, 1978 to 1982. 670 73

Twenty-eight bacteriologically proved episodes of purulent meningitis in 27 infants and children were monitored prospectively with sequential determinations of serum C-reactive protein. Except in one rapidly fatal case, all the patients showed decreasing CRP values for about 1 week. In five patients the CRP values than returned to a high level (P less than 0.001). Each of these patients developed an organic complication (subdural effusions in three, transient widening of the ventricles in one, purulent arthritis with osteomyelitis in one). Except for one infant with sensorineural hearing loss, which probably had developed early in the course of meningitis, no permanent sequelae were found in the patients with uncomplicated courses. One infant later had a relapse of Escherichia coli meningitis, reflected in a sharp increase of CRP. We conclude that sequential CRP measurements may be performed routinely to detect potential complications at an early stage of bacterial meningitis.
 ...
PMID:C-reactive protein as a detector of organic complications during recovery from childhood purulent meningitis. 672 18

Septic arthritis results from invasion of the synovium by microorganisms, and most infectious organisms can cause arthritis. In children, septic arthritis is usually associated with systemic infections such as pneumonia or meningitis; in young adults, gonococcal arthritis is the most common cause; and in the aged, septic arthritis is usually superimposed on chronic joint disease. Underlying rheumatoid arthritis is common, and Dr. Knights stresses the importance of recognizing septic arthritis as a complication of rheumatoid arthritis.
 ...
PMID:Infectious arthritis. 674 55

The frequency of human infections caused by Campylobacter (C.) jejuni is thought to be at present as significant as that of the gastroenteric salmonelloses. The clinical symptoms are mostly like enteritis, enterocolitis, acute abdomen or ileitis terminalis. Post-infection reactions are possible not only as arthritis or septicemia but also as meningitis, conjunctivitis, carditis, pneumonia, cholecystitis, peritonitis, urinary tract infection and abortion. Only cultural examinations confirm the diagnosis of an infection with C. jejuni. If chemotherapy is required, erythromycin is the remedy of choice. Animals are an important reservoir for C. jejuni, but the epidemiology of human infections with this microorganism is not well understood.
 ...
PMID:[Campylobacter jejuni--a "recent" pathogen worthy of study. Present knowledge on its clinical aspects, diagnosis, therapy and epidemiology]. 675 59

The case of a 22 months old child with no previous medical history hospitalised for an acute infection with pyrexia, arthritis, meningitis and leukocytosis with polynucleosis is reported. All bacteriological investigations were sterile; the search for soluble antigen and serological tests were negative. Antibiotic therapy (Ampicillin and Thiamphenicol) cured the meningitis and arthritis. On the 10th day of treatment the temperature rose, a systolic murmur was detected and echocardiography showed the presence of a large vegetation on the anterior mitral leaflet. Three weeks later (on Ampicillin and Amikacine), asymptomatic abolition of the femoral pulses and disappearance of the vegetation on echocardiography were observed. Angiography confirmed obstruction at the bifurcation of the aorta. Surgical removal of the embolism resulted in revascularisation of the femoral artery and was followed by apyrexia. This infant probably developed endocarditis on a healthy heart. It was complicated by systemic embolism and mitral regurgitation which at present is well tolerated.
 ...
PMID:[Infectious endocarditis of a healthy heart in an infant]. 681 95

Streptococcus suis has been identified as the most common cause of meningitis in adults in Hong Kong. The disease is characterized by occupational exposure to pigs or pork. It occurs in summer, and is associated with early, severe, sensory deafness, arthritis, uveitis, and loss of balance. Examination of the cerebrospinal fluid may show an elevated white cell count with a predominance of either polymorphs or lymphocytes. Misinterpretation of the microbiological findings by inexperienced staff members may lead to a failure to correctly diagnose this disease. This is the first report of a series of cases of Strept. suis meningitis outside western Europe. Health authorities are urged to be aware of this disease in pork-consuming countries.
 ...
PMID:Streptococcus suis meningitis. An important underdiagnosed disease in Hong Kong. 683 58

Kingella (Moraxella) kingae occasionally colonizes the nasopharynx and rarely causes serious infections. Three children with K kingae infections treated over a two-month period were studied. Epidemiologic investigation concluded that infection was community acquired, not pseudoinfection or nosocomial infection. Except for prompt laboratory recognition of the organism, no identifiable factors explained the observed prevalence. Five additional K kingae infections were reviewed. Affected sites included blood (two), valves (two), bone (two), joint (one), and disk space (one). Three patients had underlying disease; one was immunosuppressed. Kingella kingae resembles other members of the Neisseriaceae family and causes similar infections except meningitis. It is differentiated by colonial characteristics and standard biochemical tests. Treated infections responded to penicillin G potassium. Gram-negative bacteria uncommonly are implicated in endocarditis, arthritis, osteomyelitis, and diskitis; K kingae deserves recognition as a pathogen in these pediatric infections.
 ...
PMID:Kingella (Moraxella) kingae infections in children. 685 76

A largely prospective study averaging 33 months was undertaken in 30 patients with and one without (chronic) erythema migrans. In one case erythema migrans disappeared spontaneously, in the 29 others it persisted up to six months, but quickly responded to antibiotic treatment. Measured from the tick bite in 9 patients or from onset of the erythema migrans, arthritis and arthralgia appeared in ten patients on average 6.5 months (0.7-36), and persisted for eight months (0.2-42). In seven of these patients sensory disturbances appeared three weeks (1-10) later and (or) signs of meningitis which lasted for four months (0.5-16), while in three patients cardiac symptoms appeared a few weeks later, persisting for 4.5 months (0.3-12). In one patient tracheolaryngitis developed two months later, persisting for three months. These manifestations occurred in seven patients despite antibiotic treatment. Extradermal manifestations in two patients were successfully treated with high parenteral penicillin doses, in one instance followed by tetracyclin. "Erythema migrans disease", differing from Lyme disease described in the U.S.A. in only a few aspects, apparently cannot be successfully treated with low oral doses of penicillin, but can in certain circumstances be favourably influenced by high parenteral doses of penicillin G.
 ...
PMID:[Erythema migrans disease. A contribution to its clinical features and relation to Lyme disease]. 687 71


<< Previous 1 2 3 4 5 6 7 8 9 10