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Query: UMLS:C0003864 (arthritis)
 69,039 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spondyloarthritis (Sp) is newly defined as arthritis that is clinically, pathologically, and genetically related to and predisposed to ankylosing spondylitis (AS) and Reiter's syndrome (RS) rather than to rheumatoid arthritis (RA). A diagnosis of Sp does not necessarily imply arthritis of the spine and does not depend on the demonstration of roentgenographic sacroiliitis that, in this conceptualization, is recognized not as the essential hallmark, but rather merely as a diagnostic "way station" on a continuum of disease, which may (but need not necessarily) begin with RS or be complicated during its course by AS or RS. Spondyloarthritis is distinctively characterized morphologically and clinically by disproportionate inflammation at the entheses, the sites of attachment of tendons and ligaments to bone. Family history or presence of enthesopathic pain, psoriasis, inflammatory bowel disease, uveitis, recurrent urethritis, prostatitis or cervicitis, keratoderma blennorrhagicum, HLA-B27, and asymmetric pauciarticular lower lower extremity arthritis without rheumatoid factor or rheumatoid nodules suggests a diagnosis of Sp rather than RA.
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PMID:Spondyloarthritis and enthesopathy. Current concepts in rheumatology. 621 89

Complex associations between the different subgroups of seronegative arthritis, acute anterior uveitis, psoriasis and inflammatory bowel disease were found in a series of patients and relatives. Different HLA-B antigens were associated with different clinical signs. The results indicated the existence of a multigenic syndrome whose main clinical manifestations are relapsing innflammations at various sites. The genetic factors appeared to be 1) HLA-B27 associated disease susceptibility, 2) predisposition to psoriatic arthropathy, 3) predisposition to early onset familial psoriasis and, 4) a probable predisposition to inflammatory bowel disease and its associated arthropathy. The results indicated that the different genetic factors may interact and influence each other's penetrance and expression.
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PMID:Ankylosing spondylitis is part of a multifactorial syndrome: hereditary multifocal relapsing inflammation (HEMRI). 633 89

Erythema nodosum and seronegative arthritis associated with diarrhoea was previously regarded as implying the presence of inflammatory bowel disease. Recently, however, erythema nodosum has been described as a sequel to diarrhoea caused by infection with Salmonella typhimurium, Yersinia enterocolitica and Campylobacter jejuni. We report two patients in whom erythema nodosum and reactive arthritis followed acute Shigella flexneri gastroenteritis, a rare association.
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PMID:Can erythema nodosum and reactive arthritis be a sequel to Shigella flexneri gastroenteritis? 639 14

Of 12 patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) or sacroiliitis (SI), only 4 (32%) had HLA-B27. Family studies revealed 3 B27-negative relatives with AS, 1 with SI, 1 with SI and IBD, and 1 with IBD alone. HLA haplotypes did not segregate with disease. These data suggest a non-HLA linked genetic predisposition to IBD which also confers susceptibility to spondylitis, even in the absence of expression of bowel disease.
Arthritis Rheum 1980 Dec
PMID:The spondylitis of inflammatory bowel disease. Evidence for a non-HLA linked axial arthropathy. 645 May 95

This article updates progress and results to date in the Oxford Family Planning Association contraceptive study. This study involves over 17,000 women recruited at clinics in England and Scotland in 1968-74 who have been followed since then. At entry to the study, 56.6% of subjects were oral contraceptive (OC) users, 24.8% were diaphragm users, and 18.6% were IUD users. By the end of 1983, 192,000 woman-years of observation had been collected. Over 4000 women currently have at least 8 years of OC use, providing opportunities for a study of longterm and delayed effects of this contraceptive method. The data suggest changing patterns of contraceptive use over time, with a decline in OC use and a rise in the use of sterilization as subjects have aged. Progestogen-only OCs are moderately popular across the age range, but combined OCs are rarely use past the age of 40 years. Although the study was originally concerned with the risks and benefits of OC use, it has contributed to knowledge about the effects of a wide variety of contraceptive methods. In addition, it has been possible to analyze the influence of factors such as age, parity, social class, and motivation on contraceptive efficacy. 33 individual publications (listed and annotated in the article) have emerged from the study. Work is currently underway on factors affecting fertility, psychiatric illness in users of different methods, patterns of cervical cytology in women with neoplasia of the cervix uteri, the effectiveness of IUDs in women with arthritis, and the realtionship between OC use and chronic inflammatory bowel disease. Future research will focus on the delayed effects of OCs on major chronic diseases such as cancer, coronary heart disease, and diabetes. The study is funded through mid-1989.
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PMID:The Oxford-Family Planning Association contraceptive study. 650 57

A review of our records disclosed eight children with pyoderma gangrenosum. All had associated inflammatory bowel disease, and four had arthritis. In three patients the bowel disease was severe and required resection of portions of the affected bowel. The cutaneous lesions had a chronic course (average duration, 2 1/2 years), and systemic therapy was required in seven cases. Previously reported cases of pyoderma gangrenosum in children are reviewed, and the management of this skin disorder in childhood is discussed.
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PMID:Pyoderma gangrenosum in childhood. 672 42

111Indium-leucocyte scanning demonstrated enteritis in a patient with acute arthritis and diarrhoea when contrast radiology was normal. Infection with Yersinia entercolitica was proved serologically. Leucocyte scanning may be useful in the screening for inflammatory bowel disease in patients with seronegative arthritis.
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PMID:Yersinia arthritis: demonstration of occult enteritis by 111indium leucocyte scanning. 674 9

Pyoderma gangrenosum is most commonly associated with inflammatory bowel disease and rheumatoid arthritis, but it has been associated with various haematological malignancies. A 54-year-old man with no history of bowel disease or arthritis presented with a leg ulcer, which healed after treatment. Results of bone marrow aspiration were compatible with primary thrombocythaemia. Seven weeks later there were pronounced recurrence of the ulceration and pyoderma gangrenosum was diagnosed. The appearance of pyoderma gangrenosum associated with blood disorders may differ from that associated with bowel and joint disease.
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PMID:Pyoderma gangrenosum associated with primary thrombocythaemia. 681 Oct 33

An important problem in investigating food allergic diseases is to adduce evidence that specific diseases of unknown cause may be attributable to food allergy. Polyarthritis is a good example of the difficulties involved in such studies because it is a very heterogeneous disorder and generalizations about aetiology are unlikely to prove correct. We have observed transient synovitis in both children and adults which is caused by food allergy. On the other hand we have not been able to show that food allergy demonstrably contributes to juvenile chronic arthritis or to rheumatoid arthritis in adults. The arthritis associated with inflammatory bowel disease undoubtedly responds to elemental diets and the mechanism of this remission warrants further investigation.
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PMID:Joint complaints and food allergic disorders. 688 14

The major histocompatibility complex on the sixth chromosome controls expression of a complex series of cell surface antigens which comprise the human leukocyte antigen (HLA) system. These markers, beyond their importance in human organ transplantation, have been demonstrated to occur with an increased prevalence in certain disease states. The group of conditions showing the closest association with specific HLA antigens are the "spondyloarthropathies." These include ankylosing spondylitis (AS), Reiter's syndrome (RS), psoriatic arthritis (PsA), and the arthritis of inflammatory bowel disease (AIBD). Clinical and radiographic studies were made of 310 unrelated caucasoid patients with seronegative arthritis. HLA-A, B, C, and DR typing were performed using the microdroplet lymphocyte cytotoxicity test. Statistically increased prevalences of A26, B27, and Bw38 were observed, while B27 was associated with spinal involvement regardless of diagnosis (90 percent in AS p less than 0.0001). Experiments found A26 (23 percent p less than 0.001) and Bw38 (38 percent p less than 0.0001) in patients with PsA. Spondyloarthritis patients with spinal involvement who lacked B27 frequently had B7. The HLA DR typing for seven specificities was carried out in 196 patients. It was found that DRw4 (52 percent p less than 0.03) and DRw7 (39 percent p less than 0.04) were increased in the PsA patients. This study further confirms the close association of HLA antigens and the spondylarthropathies.
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PMID:The major histocompatibility complex. 695 Jun 86


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