Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003862 (arthralgia)
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Human Gene/Protein
ZDHHC19 10.5
cartilage intermediate layer protein 2 10.1
EEA1 protein 9.3
caspase recruitment domain-containing protein 15 9.1
CIAS1 9.0
envelope polyprotein 8.9
SH3KBP1 8.8
CHED 8.7
LRRC15 8.7
CDC-like kinase 2 8.7
UfSP2 8.7
TNFRSF1A 8.6
MATN3 8.5
ST6GALNAC1 8.4
COL9A3 8.4
C4B3 8.3
CAPZA2 8.3
MVK 8.2
MRGPRD 8.1
Mevalonate kinase 8.1
COL9A1 8.0
NALP3 8.0
CAPZA1 7.9
COL9A2 7.9
BARX1 7.9
SIGLEC1 7.9
SLCO2A1 7.8
PIGT 7.7
FMF 7.7
Rheumatoid factor 7.7
Platelet-activating factor acetylhydrolase 7.7
MEFV 7.6
progressive ankylosis protein 7.6
NXP2 7.6
MS4A4A 7.6
RDC 7.5
Properdin factor B 7.5
Leu-16 7.5
Coagulation factor XII 7.4
CHST14 7.4
CANT1 7.4
TMD 7.3
GIL 7.3
WISP3 7.3
ubiquitin-fold modifier 1 7.2
NIMA-related kinase 2 7.2
CAPZB 7.2
rheumatoid factor 7.1
PM-Scl 7.1
RPL3 7.1
MTMR14 7.1
PRES 7.0
GNPTG 7.0
V4-6 7.0
PDYN 7.0
C4A4 6.9
B94 6.9
B19 6.9
mevalonate kinase 6.9
HPGD 6.9
ASAH1 6.8
TNXB 6.8
nuclear pore complex protein 6.7
MNX 6.7
AHCY 6.7
Capsid protein 6.7
TTK protein kinase 6.7
HOA 6.7
HLA-B51 6.7
TLH 6.7
tenascin-X 6.6
MAP17 6.6
ADAM 12 6.6
CECR1 6.6
60kD 6.5
OX-2 6.5
SS-A 6.5
CRES 6.5
AO2 6.5
NLRP12 6.4
more...
Disease
SLE with diffuse proliferative glomerulonephritis 12.1
Barmah Forest disease 12.1
Tibial collateral ligament bursitis 12.1
Intracardiac mass 12.1
Rheumatic pneumonia 12.1
Transient arthritis 12.1
Syphilitic synovitis 12.1
Mayaro fever 11.4
Chronic meningococcemia 11.3
Iliac vein thrombosis 11.1
Gingival ulceration 11.1
Flu symptoms 11.1
megalerythema 11.1
Early cirrhosis 11.1
Drug-induced aplastic anemia 11.1
Retrosternal abscess 11.1
Erythema marginatum 10.8
Borderline lepromatous leprosy 10.5
Gas bubble disease 10.5
CCAL1 10.5
Idiopathic plasmacytic lymphadenopathy 10.5
Seronegative arthritis 10.5
Chronic osteoarthritis 10.5
pericementitis 10.5
Acute synovitis 10.3
Schnitzler syndrome 10.3
ATIN 10.1
Flu-like syndrome 10.1
Sindbis fever 10.1
Ockelbo disease 10.0
Chikungunya virus infection 10.0
Adult-onset Still's disease 10.0
HIDS 9.9
Hypocomplementemic urticarial vasculitis 9.9
Venezuelan hemorrhagic fever 9.9
Periapical abscesses 9.8
sacroiliac arthritis 9.8
CCAL2 9.8
Hypermobility syndrome 9.7
Oligoarthritis 9.7
Cutaneous polyarteritis nodosa 9.6
Descending colon 9.5
Gigantism and acromegaly 9.5
Wissler-Fanconi syndrome 9.5
Descending colon 9.5
IgG gammopathy 9.5
Calcinosis universalis 9.5
pleurisy with effusion 9.5
Hypertrophic pulmonary osteoarthropathy 9.5
Zika virus disease 9.3
Juvenile ankylosing spondylitis 9.3
Thyroid acropachy 9.3
epipharyngitis 9.3
Self-healing juvenile cutaneous mucinosis 9.3
Acne fulminans 9.2
RS3PE syndrome 9.1
monarticular arthritis 9.1
psilosis 9.1
Pityriasis lichenoides chronica 9.1
Mesenteric vasculitis 9.1
NOMID 9.1
Essential mixed cryoglobulinemia 9.0
IgM gammopathy 9.0
Ectopic parathyroid adenoma 8.9
Generalized eruptive histiocytoma 8.9
Type III reaction 8.9
Negative thoughts 8.9
Unilateral condylar hyperplasia 8.9
Mixed cryoglobulinemia 8.9
Muckle-Wells syndrome 8.9
polyarthralgia 8.9
Temporomandibular Disorders 8.8
Multiple epiphyseal dysplasia 8.8
Pseudoachondroplasia 8.8
Acne conglobata 8.8
Cryoglobulinemic vasculitis 8.8
FRNS 8.8
Necrotizing glomerulonephritis 8.8
chikungunya 8.8
hypertrophic osteoarthropathy 8.8
more...
Symptom
Cervical facet joint pain 12.1
arthralgia 12.1
Ankle joint pain 12.1
Facet joint pain 11.5
Sacroiliac joint pain 11.5
General symptoms and signs 11.1
joint crepitus 10.7
Acute back pain 9.9
Oral discomfort 9.8
joint symptom 9.8
General discomfort 9.5
Generalized fatigue 9.5
myalgia 9.4
Axillary lymphadenopathy 9.3
CVA tenderness 9.3
Gastrointestinal signs and symptoms 9.3
change in bowel movements 9.3
liver pain 9.1
Musculoskeletal symptoms 9.1
enanthema 9.0
calf cramps 8.8
Osler's nodes 8.4
Urticarial vasculitis 8.2
prickling sensation 8.2
sinus pain 8.2
feeling exhausted 8.2
Nuchal rigidity 8.1
growing pains 8.1
hand pain 7.9
GI pain 7.9
clubbing 7.8
Quadriceps weakness 7.8
Koplik spots 7.8
Joint hypermobility 7.7
jaw pain 7.6
Scrotal pain 7.6
body pain 7.5
sore throat 7.5
Cramping 7.5
Other pain 7.4
pain in the buttock 7.4
coccygodynia 7.4
Referred pain 7.4
PUO 7.4
Pain symptoms 7.3
Erythema annulare centrifugum 7.3
periorbital edema 7.3
Chronic abdominal pain 7.3
polymyalgia 7.3
General symptoms 7.2
abnormal taste 7.2
neurological pain 7.2
Climacteric symptoms 7.2
GI irritation 7.2
swollen joints 7.1
Mechanical pain 7.1
vaginal itching 7.0
chills 7.0
Skin symptoms 7.0
weight problem 7.0
joint stiffness 7.0
generalized rash 7.0
finger pain 6.9
skin pain 6.9
orofacial pain 6.8
lassitude 6.8
musculoskeletal impairment 6.8
prostration 6.7
dry throat 6.7
eye pain 6.7
pedal edema 6.7
lumbar back pain 6.7
asthenia 6.6
sialectasis 6.6
knee pain 6.6
bone pain 6.6
meningism 6.5
generalized pain 6.5
hot flushes 6.5
koilonychia 6.5
more...
Drug
Aristospan 10.5
Tesamorelin 10.3
Depo-medrol 10.1
Solganal 8.9
Cefditoren pivoxil 8.7
Etidronate disodium 8.5
Roquinimex 8.2
Dexibuprofen 8.2
LYMErix 8.2
Fangfeng 8.2
Dalfopristin 8.2
Agalsidase alfa 8.1
Fangji 8.1
Calamine 8.0
Zonegran 7.9
Accolate 7.9
Dipentum 7.8
Roferon A 7.7
Berberine chloride 7.4
Minocin 7.3
Tolmetin sodium 7.3
Efalizumab 7.3
Efalizumab 7.2
Biltricide 7.2
Femara 7.2
Anakinra 6.9
Feldene 6.9
Ephedrae Herba 6.8
Ixabepilone 6.7
Interferon alfa-2a 6.7
Naproxen sodium 6.7
Somatropin 6.6
Alfacalcidol 6.6
Vioxx 6.6
Orthoclone OKT3 6.5
Synercid 6.2
Adefovir dipivoxil 6.2
Fenoprofen 6.2
Celebrex 6.2
OctreoScan 6.1
Anafranil 6.1
Adalimumab 6.1
Sesame oil 6.0
Gabexate mesilate 5.9
Naprosyn 5.9
Pegvisomant 5.7
Voltaren 5.7
Tocilizumab 5.7
Diclofenac sodium 5.7
Sandostatin LAR 5.7
Domin 5.7
Azacytidine 5.6
Mizoribine 5.5
Deferasirox 5.5
Pefloxacin 5.5
Imuran 5.5
Prednisone 5.4
Anafranil 5.4
Marcaine 5.4
CFS 5.4
Basiliximab 5.4
Basiliximab 5.4
Tapentadol 5.3
Infliximab 5.3
Mesalazine 5.3
Infliximab 5.3
Intron A 5.3
Methylprednisolone 5.3
Zoledronic acid 5.3
Prednisolone 5.3
Sodium citrate 5.3
Sodium citrate 5.3
Zoledronic acid 5.1
Antithymocyte globulin 5.1
Taxol 5.1
Intron A 5.1
CTRX 5.1
Intron A 5.0
Isotretinoin 5.0
IL-1ra 5.0
more...
Enzyme
glycerophosphodiester phosphodiesterase 7.3
mevalonate kinase 6.8
GP-I 6.2
homogentisate 1,2-dioxygenase 6.1
proteinase-3 5.3
HOA 5.1
homoserine kinase 5.1
GMT 4.7
MCS 4.5
Lod 4.5
GAR 4.2
thiopurine methyltransferase 4.0
MDP 3.9
MTD 3.9
aldolase 3.8
ceramidase 3.7
alpha-galactosidase 3.7
peptidylarginine deiminase 3.6
PME 3.6
botulinum neurotoxin 3.5
MMP-3 3.4
sulfite oxidase 3.3
sulfite oxidase 3.2
alanine aminotransferase 3.2
prolidase 3.2
C3 convertase 3.1
AST 3.0
creatine kinase 2.9
porphobilinogen deaminase 2.8
aspartate aminotransferase 2.8
monoacylglycerol lipase 2.7
methionine adenosyltransferase 2.7
E-2 2.7
glucocerebrosidase 2.6
aldehyde oxidase 2.6
cytosine deaminase 2.6
CFI 2.5
dihydropyrimidine dehydrogenase 2.5
delta-aminolevulinic acid dehydratase 2.3
PAM 2.2
TdT 2.2
BIS 2.2
chondroitinase 2.1
angiotensin-converting enzyme 2 2.1
nucleotidase 2.1
thymidine phosphorylase 2.1
gamma-glutamyl transpeptidase 2.0
alkaline phosphatase 2.0
21-hydroxylase 1.9
uricase 1.9
transglutaminase 1.9
dihydropyrimidine dehydrogenase 1.8
xanthine dehydrogenase 1.8
caspase-1 1.8
11beta-hydroxysteroid dehydrogenase 1.8
asparaginase 1.7
lactate dehydrogenase 1.7
MDR 1.6
deoxyribonuclease 1.6
ACE 1.5
deoxyribonuclease 1.5
thyroid peroxidase 1.5
Alternating 1.5
transcriptase 1.5
MIP 1.4
peroxidase 1.4
ceruloplasmin 1.4
PTA 1.4
ornithine transcarbamylase 1.4
AOR 1.3
CD13 1.3
cathepsin G 1.3
collagenase 1.3
prostaglandin synthetase 1.3
cathepsin K 1.3
NADPH-diaphorase 1.2
BAL 1.2
xanthine oxidase 1.1
MMP 1.1
calcineurin 1.1
more...
Compound
methyl hexopyranosiduronic acid 11.1
Protoanemonin 9.4
Anatabine 8.8
DADDS 8.4
Dalfopristin 8.2
C6H8O4 8.2
Quinupristin 8.2
Isofraxidin 7.9
Antineoplaston A10 7.7
Aurothioglucose 7.5
Etiocholanolone 7.5
S-15 7.5
Poly ICLC 7.5
Dihydrocodeine 7.4
Versene 7.3
Berberine chloride 7.2
Betnesol 7.1
Fangchinoline 7.1
Antineoplaston A10 7.1
Solasodine 7.0
Azapropazone 6.9
Exemestane 6.7
Methylsulfonylmethane 6.6
3-chloropyridine 6.5
Anastrozole 6.5
Solu-Medrol 6.5
Fenoprofen 6.4
ANCA 6.4
Rifabutin 6.4
Fluocinolone acetonide 6.4
Tolmetin 6.3
Letrozole 6.2
3-hydroxyoctanoic acid 6.2
4-(methylsulfonyl)phenyl 6.2
Guggulsterone 6.1
HAQ 6.1
Glucosamine 6.0
thieno[2,3-b]pyridine 6.0
Chlordecone 5.9
Cromolyn 5.7
Salina 5.7
Resiniferatoxin 5.7
Sulfasalazine 5.6
R 2010 5.5
Cloxacillin 5.5
Nefazodone 5.5
Etoricoxib 5.5
CCP 5.4
Benznidazole 5.4
Benznidazole 5.4
Benznidazole 5.4
Rose Bengal 5.4
Potassium permanganate 5.4
ANA 5.4
ANA 5.4
Ropinirole 5.3
Etretinate 5.3
Paclitaxel 5.3
Levamisole 5.3
Nateglinide 5.3
Palmitoylethanolamide 5.3
Diethylcarbamazine 5.3
Zinc protoporphyrin 5.2
Hydroxychloroquine 5.2
Methylprednisolone 5.2
Pyrazinamide 5.2
ASK 5.2
Prednisolone 5.2
Allyl isothiocyanate 5.2
Etanercept 5.2
Ceftizoxime 5.1
Cyanate 5.1
HN3 5.1
Colchicine 5.1
maslinic acid 5.1
Piroxicam 5.0
CD 3 5.0
DMPS 4.9
Azathioprine 4.9
D-glucosamine 4.9
more...