Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003862 (arthralgia)
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Human Gene/Protein
ZDHHC19 10.5
cartilage intermediate layer protein 2 10.1
EEA1 protein 9.3
caspase recruitment domain-containing protein 15 9.1
CIAS1 9.0
envelope polyprotein 8.9
SH3KBP1 8.8
LRRC15 8.7
UfSP2 8.7
CHED 8.7
CDC-like kinase 2 8.7
TNFRSF1A 8.6
MATN3 8.5
ST6GALNAC1 8.4
COL9A3 8.4
CAPZA2 8.3
C4B3 8.3
MVK 8.2
MRGPRD 8.1
Mevalonate kinase 8.1
COL9A1 8.0
NALP3 8.0
CAPZA1 7.9
COL9A2 7.9
BARX1 7.9
SIGLEC1 7.9
SLCO2A1 7.8
PIGT 7.7
FMF 7.7
Rheumatoid factor 7.7
Platelet-activating factor acetylhydrolase 7.7
MEFV 7.6
NXP2 7.6
progressive ankylosis protein 7.6
MS4A4A 7.6
RDC 7.5
Properdin factor B 7.5
Leu-16 7.5
Coagulation factor XII 7.4
CANT1 7.4
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Disease
Intracardiac mass 12.1
Syphilitic synovitis 12.1
Transient arthritis 12.1
Rheumatic pneumonia 12.1
Barmah Forest disease 12.1
Tibial collateral ligament bursitis 12.1
SLE with diffuse proliferative glomerulonephritis 12.1
Mayaro fever 11.4
Chronic meningococcemia 11.3
megalerythema 11.1
Retrosternal abscess 11.1
Drug-induced aplastic anemia 11.1
Gingival ulceration 11.1
Iliac vein thrombosis 11.1
Early cirrhosis 11.1
Flu symptoms 11.1
Erythema marginatum 10.8
Idiopathic plasmacytic lymphadenopathy 10.5
CCAL1 10.5
pericementitis 10.5
Borderline lepromatous leprosy 10.5
Chronic osteoarthritis 10.5
Seronegative arthritis 10.5
Gas bubble disease 10.5
Acute synovitis 10.3
Schnitzler syndrome 10.3
ATIN 10.1
Sindbis fever 10.1
Flu-like syndrome 10.1
Ockelbo disease 10.0
Chikungunya virus infection 10.0
Adult-onset Still's disease 10.0
HIDS 9.9
Venezuelan hemorrhagic fever 9.9
Hypocomplementemic urticarial vasculitis 9.9
CCAL2 9.8
Periapical abscesses 9.8
sacroiliac arthritis 9.8
Hypermobility syndrome 9.7
Oligoarthritis 9.7
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Symptom
Ankle joint pain 12.1
arthralgia 12.1
Cervical facet joint pain 12.1
Sacroiliac joint pain 11.5
Facet joint pain 11.5
General symptoms and signs 11.1
joint crepitus 10.7
Acute back pain 9.9
Oral discomfort 9.8
joint symptom 9.8
Generalized fatigue 9.5
General discomfort 9.5
myalgia 9.4
Gastrointestinal signs and symptoms 9.3
CVA tenderness 9.3
Axillary lymphadenopathy 9.3
change in bowel movements 9.3
liver pain 9.1
Musculoskeletal symptoms 9.1
enanthema 9.0
calf cramps 8.8
Osler's nodes 8.4
Urticarial vasculitis 8.2
feeling exhausted 8.2
sinus pain 8.2
prickling sensation 8.2
Nuchal rigidity 8.1
growing pains 8.1
hand pain 7.9
GI pain 7.9
clubbing 7.8
Quadriceps weakness 7.8
Koplik spots 7.8
Joint hypermobility 7.7
jaw pain 7.6
Scrotal pain 7.6
body pain 7.5
sore throat 7.5
Cramping 7.5
pain in the buttock 7.4
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Drug
Aristospan 10.5
Tesamorelin 10.3
Depo-medrol 10.1
Solganal 8.9
Cefditoren pivoxil 8.7
Etidronate disodium 8.5
Dalfopristin 8.2
Fangfeng 8.2
Dexibuprofen 8.2
Roquinimex 8.2
LYMErix 8.2
Agalsidase alfa 8.1
Fangji 8.1
Calamine 8.0
Zonegran 7.9
Accolate 7.9
Dipentum 7.8
Roferon A 7.7
Berberine chloride 7.4
Minocin 7.3
Tolmetin sodium 7.3
Efalizumab 7.3
Efalizumab 7.2
Biltricide 7.2
Femara 7.2
Anakinra 6.9
Feldene 6.9
Ephedrae Herba 6.8
Ixabepilone 6.7
Interferon alfa-2a 6.7
Naproxen sodium 6.7
Alfacalcidol 6.6
Somatropin 6.6
Vioxx 6.6
Orthoclone OKT3 6.5
Synercid 6.2
Adefovir dipivoxil 6.2
Fenoprofen 6.2
Celebrex 6.2
OctreoScan 6.1
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Enzyme
glycerophosphodiester phosphodiesterase 7.3
mevalonate kinase 6.8
GP-I 6.2
homogentisate 1,2-dioxygenase 6.1
proteinase-3 5.3
HOA 5.1
homoserine kinase 5.1
GMT 4.7
MCS 4.5
Lod 4.5
GAR 4.2
thiopurine methyltransferase 4.0
MDP 3.9
MTD 3.9
aldolase 3.8
ceramidase 3.7
alpha-galactosidase 3.7
peptidylarginine deiminase 3.6
PME 3.6
botulinum neurotoxin 3.5
MMP-3 3.4
sulfite oxidase 3.3
sulfite oxidase 3.2
alanine aminotransferase 3.2
prolidase 3.2
C3 convertase 3.1
AST 3.0
creatine kinase 2.9
porphobilinogen deaminase 2.8
aspartate aminotransferase 2.8
monoacylglycerol lipase 2.7
methionine adenosyltransferase 2.7
E-2 2.7
glucocerebrosidase 2.6
aldehyde oxidase 2.6
cytosine deaminase 2.6
CFI 2.5
dihydropyrimidine dehydrogenase 2.5
delta-aminolevulinic acid dehydratase 2.3
PAM 2.2
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Compound
methyl hexopyranosiduronic acid 11.1
Protoanemonin 9.4
Anatabine 8.8
DADDS 8.4
Dalfopristin 8.2
C6H8O4 8.2
Quinupristin 8.2
Isofraxidin 7.9
Antineoplaston A10 7.7
Aurothioglucose 7.5
S-15 7.5
Etiocholanolone 7.5
Poly ICLC 7.5
Dihydrocodeine 7.4
Versene 7.3
Berberine chloride 7.2
Fangchinoline 7.1
Betnesol 7.1
Antineoplaston A10 7.1
Solasodine 7.0
Azapropazone 6.9
Exemestane 6.7
Methylsulfonylmethane 6.6
3-chloropyridine 6.5
Anastrozole 6.5
Solu-Medrol 6.5
Fenoprofen 6.4
ANCA 6.4
Rifabutin 6.4
Fluocinolone acetonide 6.4
Tolmetin 6.3
Letrozole 6.2
3-hydroxyoctanoic acid 6.2
4-(methylsulfonyl)phenyl 6.2
Guggulsterone 6.1
HAQ 6.1
Glucosamine 6.0
thieno[2,3-b]pyridine 6.0
Chlordecone 5.9
Cromolyn 5.7
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