Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003635 (apraxia)
 2,817 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A systematic evaluation of cognitive function is an integral part of the neurological examination. Behavioral measures could detect functional impairment that is too subtle to be detected by current neurological procedures. Neuropsychological examination should cover both general and specific cognitive processes. The level of general attention or emotional change may affect variety of cognitive processes. Impairment of a functional system due to a focal cerebral damage results in a specific cognitive dysfunction such as aphasia, apraxia, agnosia, etc. Simplified but systematic methods to assess basic neuropsychological functions are suitable for everyday clinical examination by neurologists. A relatively short form of the cognitive status examination was devised, which covers general attention, language, calculation, praxis, visuospatial ability, directional attention and memory. Not only quantitative but also qualitative assessment of patients' performance would give clinicians valuable clues for the neuronal bases of cognitive functions.
 ...
PMID:[Neuropsychological evaluation as a part of the neurological examination]. 1934 71

Cognitive assessments after stroke are typically short form tests developed for dementia that generates pass/fail classifications (e.g. the MoCA). The Oxford Cognitive Screen (OCS) provides a domain-specific cognitive profile designed for stroke survivors. This study compared the use of the MoCA and the OCS in acute stroke with respect to symptom specificity and aspects of clinical utility. A cross-sectional study with a consecutive sample of 200 stroke patients within 3 weeks of stroke completing MoCA and OCS. Demographic data, lesion side and Barthel scores were recorded. Inclusivity was assessed in terms of completion rates and reasons for non-completion were evaluated. The incidence of cognitive impairments on both the MoCA and OCS sub-domains was calculated and differences in stroke specificity, cognitive profiles and independence of the measures were addressed. The incidence of acute cognitive impairment was high: 76% of patients were impaired on MoCA, and 86% demonstrated at least one impairment on the cognitive domains assessed in the OCS. OCS was more sensitive than MoCA overall (87 vs 78% sensitivity) and OCS alone provided domain-specific information on prevalent post-stroke cognitive impairments (neglect, apraxia and reading/writing ability). Unlike the MOCA, the OCS was not dominated by left hemisphere impairments but gave differentiated profiles across the contrasting domains. The OCS detects important cognitive deficits after stroke not assessed in the MoCA, it is inclusive for patients with aphasia and neglect and it is less confounded by co-occurring difficulties in these domains.
 ...
PMID:Domain-specific versus generalized cognitive screening in acute stroke. 2658 18