Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UMLS:C0003615 (
appendicitis
)
4,439
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study, we examined the distribution and origin of myofibroblasts around the perforations of
appendicitis
. Stromal cells of 45 cases were studied by immunohistochemistry. In the normal appendix, myofibroblasts were restricted to the mucosa, and CD34-positive stromal cells were distributed in the submucosal and subserosal layers. Some mesothelial cells were positive for cytokeratin CAM5.2,
cytokeratin 5
, or mesothelial cells (HBME-1). In perforation of
appendicitis
with both abscess and granulation tissue, a small to moderate or a moderate to large number of myofibroblasts appeared in the subserosal area around the perforation, respectively, but CD34-positive stromal cells were completely absent there. In the subserosal area of the perforation of
appendicitis
with abscess,
cytokeratin 5
-positive stromal cells were absent. However, a small to moderate number of cytokeratin CAM5.2-positive stromal cells were observed there. Double immunostaining showed the coexpression of alpha-smooth muscle actin (ASMA) and cytokeratin CAM5.2 and the coexpression of
cytokeratin 5
and cytokeratin CAM5.2 in many or some stellate-shaped or spindle-shaped stromal cells existing in the subserosal area with granulation tissue around the perforation of
appendicitis
, respectively. Finally, many myofibroblasts appearing in the subserosal area of the perforation of
appendicitis
may be derived from submesothelial cells or mesothelial cells.
...
PMID:CAM5.2-positive subserosal myofibroblasts in appendicitis. 1718 84
