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Query: UMLS:C0003615 (appendicitis)
 4,439 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Appendicitis is a common surgical problem that is associated with a systemic inflammatory response. Previous studies have shown that cytokines are activated early in acute inflammation and sepsis and may serve as indicators of clinical severity. In this study we examined the role of cytokines as serum markers to distinguish nonperforated versus perforated appendicitis. Patients with the presumptive diagnosis of appendicitis had serum drawn preoperatively. Only patients (n = 59) with an intraoperative diagnosis of nonperforated (n = 34) and perforated (n = 25) appendicitis had serum drawn 12 hours postoperatively. Diagnosis was later confirmed by pathologic examination. The serum specimens were batch analyzed using enzyme-linked immunosorbent assays specific for interleukin (IL)-1beta, IL-2, IL-6, IL-8, and IL-10. Serum from normal healthy subjects served as control specimens (n = 9). Patients in the nonperforated and perforated groups were similar with regard to age, gender, race, white blood cell count, and fever. All cytokine levels including preoperative, postoperative, nonperforated, and perforated were higher in patients with appendicitis as compared with controls. IL-1beta, IL-2, and IL-10 levels were not different between groups with appendicitis. Preoperative serum levels of IL-6 (P = 0.036) and IL-8 (P = 0.047) were higher in patients with perforated versus nonperforated appendicitis. In addition postoperative serum levels of IL-6 (P = 0.0001) remained higher in the perforated group versus the nonperforated group. Serum levels of IL-6 and IL-8 may have a role in discerning the extent of disease in this condition. This initial step in systemically studying the role of cytokines in this disease may ultimately lead to the development of molecular indicators to aid in diagnosis and differentiate appendicitis from other conditions.
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PMID:Human cytokine levels in nonperforated versus perforated appendicitis: molecular serum markers for extent of disease? 1251 3

The clinical investigation included 48 patients with acute adhesive intestinal obstruction resulting from appendectomy and an analysis of the cytokine status in 34 children with acute phlegmonous appendicitis. The patients were divided into two groups: a "polyenzyme" group and a "monoenzyme" group (Hyaluronidase). In the "polyenzyme" group the children were given the preparation Wobenzym in addition to the complex therapy, in the "monoenzyme" group--electrophoresis of Hyaluronidase. In the "monoenzyme" group there were 2 cases of intestinal obstruction. The patients from the "polyenzyme" group had no postoperative complications. Wobenzym was shown to reduce (p < 0.05) the level of pro-inflammatory cytokines (IL-2, IL-6, TNF-alpha) and to increase the level of anti-inflammatory cytokine (IL-4). Using the polyenzyme preparations after abdominal operations in children was found to promote the reduction of intra-abdominal adhesion and inflammatory processes.
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PMID:[Polyenzymatic therapy in prevention of adhesive processes in the abdominal cavity in children]. 1656 57

The levels of cytokines (IL-1beta, IL-6, TNF-alpha, IL-2, IL-10) in patients with phlegmonous appendicitis and abdominal tuberculoses were studied. It is established that the level of cytokines IL-1beta, IL-6, TNF-alpha considerably increases in patients with acute inflammatory process (phlegmonous appendicitis) and the level of interleukines IL-2, IL-10 considerably increases in patients with chronic inflammatory process (abdominal tuberculoses). Such parity of the cytokines levels can serve as a marker for differential diagnostics of acute and chronic inflammatory processes in abdominal cavity.
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PMID:[Cytokine spectrum of blood serum during inflammatory processes in the abdominal cavity]. 2126 78