Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003129 (Anoxia)
 551 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In-vitro studies of helically-cut segmental pulmonary artery strips from 43 patients undergoing thoracic surgery were performed. Cumulative dose-response contraction curves were elicited, mean maximum contraction was significantly greater from histamine (Hist) than from prostaglandin F2 alpha (PGF2 alpha), serotonin (5-HT), angiotensin II (A II) or noradrenaline (NA). Hist and PGF2 alpha showed significantly lower values for ED50 than NA, 5-HT and A II. Anoxia did not constrict the isolated arteries.
Gen Pharmacol 1983
PMID:Hypoxic and embolic pulmonary vasoconstriction. 682 27

1. Taurine is found as a free amino acid in plasma and many tissues such as heart, muscle, brain and blood. Its exact role is not fully defined but it appears to have an important effect on the function of the heart. 2. The purpose of this study was to investigate the effects of taurine (10(-3) M and 10(-2) M) on malondialdehyde levels in perfused heart muscle. 3. In this study we found that administrated taurine before anoxia and reperfusion increased the malondialdehyde levels but administrated taurine after anoxia decreased the malondialdehyde levels in perfused heart muscle compared to the taurine administrated group before anoxia. 4. Anoxia did not change the perfused heart muscle malondialdehyde levels.
Gen Pharmacol 1993 Nov
PMID:The effects of taurine on perfused heart muscle malondialdehyde levels. 811 13

1. Bullfrogs (Rana catesbiana) and rats have been subjected to high barometric pressures and studied for bubble formation on subsequent decompression to sea level. Pressures varying from 3 to 60 pounds per square inch, in excess of atmospheric pressure, were used. 2. Muscular activity after decompression is necessary for bubble formation in bullfrogs after pressure treatment throughout the above range. Anesthetized frogs remained bubble-free following decompression. Rats compressed at 15 to 45 pounds per square inch likewise did not contain bubbles unless exercised on return to sea level. 3. Bubbles form without voluntary muscular activity in anesthetized rats previously subjected to pressure of 60 pounds per square inch. Small movements involved in breathing and other vital activities are believed sufficient to initiate bubbles in the presence of very high supersaturations of N(2). 4. Bubbles appear (with exercise) in rats previously compressed at 15 pounds per square inch, and in bullfrogs subjected to pressure at levels as low as 3 pounds per square inch above atmospheric pressure. The percentage drop in pressure necessary for bubble formation is less in compressed animals than in those decompressed from sea level to simulated altitudes. 5. The action of exercise on bubble formation in compressed frogs and rats is attributed to mechanical factors associated with muscular activity, combined with the high supersaturation of N(2). CO(2) probably is not greatly involved, since its concentration does not reach supersatuation, as it does at high altitude. 6. Anoxia following decompression from high barometric pressures has no observable facilitating effect on bubble formation.
J Gen Physiol 1945 Jan 20
PMID:THE RELATION OF EXERCISE TO BUBBLE FORMATION IN ANIMALS DECOMPRESSED TO SEA LEVEL FROM HIGH BAROMETRIC PRESSURES. 1987 17