Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0003129 (
Anoxia
)
551
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Magnetic resonance spectroscopy is able to measure noninvasively a variety of important metabolites involved in cell energetics. These include phosphocreatine, ATP, inorganic phosphate, pH, and lactate.
Anoxia
, ischemia, and infarction produce rapid loss of high-energy phosphates and accumulation of hydrolysis products. Many animal studies have shown that
MRS
monitors metabolic changes in various models of human disease. The availability of large, high field magnets and the development of noninvasive localization techniques permits
MRS
to be performed on selected volumes within the body. It is now clear that
MRS
in humans will be immediately useful in several areas including studies of malignancy, ischemia, and infarction of various organs and metabolic disorders. It is expected that human
MRS
will be increasingly used for clinical investigation and eventually for medical diagnosis.
...
PMID:NMR spectroscopy for clinical medicine. Animal models and clinical examples. 332 57
