Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003128 (anovulation)
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Human Gene/Protein
DENND1A protein 12.2
RAB5B 11.6
DENND1A 10.9
C9orf3 10.6
PAPS synthase 2 10.6
WNT-4 10.3
STAR protein 9.8
LXRA 9.7
alpha-albumin 9.4
PRKAA 9.1
cytochrome P450c 9.0
P450C17 8.9
RAB5A 8.8
MSY2 8.8
LRF 8.7
LHCGR 8.7
THADA 8.7
BITE 8.7
thrombospondin-like 8.6
transgelin 2 8.4
connexin 37 8.4
CAPN10 8.4
sex hormone-binding globulin 8.4
UST 8.3
chorionic gonadotropin beta subunit 8.2
chemokine-like receptor 1 8.2
TOX3 8.0
INSR 7.9
ADAMTS1 7.9
ZFP36L2 7.9
Sulfite oxidase 7.8
luteinizing hormone receptor 7.8
MAP3K8 7.8
sex hormone binding globulin 7.7
human leukocyte antigen class II 7.7
FSH 7.7
PEPI 7.6
AMH 7.6
ANGPT1 7.5
follicle-stimulating hormone 7.5
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Disease
dysfunction; endocrine 14.2
Oligoovulation 14.2
anovulation 14.2
Fear of pregnancy 12.6
Adrenal Cushing's syndrome 12.6
Anovulatory 11.6
hyperandrogenism 11.5
poor fetal development 11.2
polymenorrhea 11.1
Precocious pubarche 11.0
polycystic ovary syndrome 10.6
Androgen excess 10.5
Post-pill amenorrhea 10.3
ovarian dysfunction 10.3
endocrine disorder 10.2
Cervical erosion 10.2
nymphomania 10.2
genital disorder 10.1
Lactational amenorrhea 10.1
reproductive disorder 9.9
female subfertility 9.8
Endometrial atrophy 9.7
Hypothalamic amenorrhea 9.7
sexual dysfunction and infertility 9.7
Primary infertility 9.4
Premature adrenarche 9.3
amenorrhea 9.3
secondary amenorrhea 9.3
Subfertility 9.1
compulsive overeating 9.1
galactorrhea 9.1
galactorrhea 9.0
Genital tuberculosis 8.9
hyperprolactinemia 8.8
Retained placenta 8.8
Severe pre-eclampsia 8.6
endometrial hyperplasia 8.6
hypomenorrhea 8.5
metastatic endometrial cancer 8.5
Ovarian failure 8.5
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Symptom
ovulatory bleeding 10.6
Intermenstrual bleeding 10.2
reproductive problem 9.0
irregular bleeding 9.0
Vaginal dryness 9.0
menometrorrhagia 8.5
female puberty 7.3
male subfertility 7.1
physical symptom 6.2
hyperemesis 5.9
masculinization 5.9
mastalgia 5.6
menopausal symptoms 5.5
POA 5.1
overweight 4.9
pelvic pain 4.5
hot flashes 4.1
urinary frequency 4.0
physical appearance 3.6
photophobia 3.6
bloating 3.5
insomnia 2.4
anorexia 2.0
shortness of breath 1.8
nausea 1.7
myalgia 1.5
starvation 1.2
syncope 1.0
nausea and vomiting 0.9
discomfort 0.7
agitation 0.6
back pain 0.6
discomfort 0.6
fatigue 0.5
stigma 0.5
exhaustion 0.4
abdominal pain 0.2
vomiting 0.2
anesthesia 0.0
headache -0.0
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Drug
Bravelle 11.0
Menotropins 10.7
Clomiphene citrate 10.3
Myo-Inositol 9.9
Gonadorelin 9.7
Humegon 9.5
Actos 9.4
Gonal-F 9.2
Gonal-F 9.0
Actos 9.0
Posilac 8.9
Terguride 8.6
Avandia 8.6
Lumiracoxib 8.6
Femara 8.2
Levonorgestrel 8.2
Deslorelin 8.1
Implanon 7.6
Ovulen 7.6
Premarin 7.5
Depo-Provera 7.4
Parlodel 7.4
FSH-beta 7.2
Luteinizing 7.1
Parlodel 7.0
HCG 6.9
2-Methoxyestradiol 6.8
Norplant 6.7
Norplant 6.5
NOV 6.4
Estrogens 6.4
Sulpiride 6.0
DHT 5.7
DHT 5.6
Orlistat 5.6
Rosiglitazone 5.5
Dihydrotestosterone 5.5
Finasteride 5.4
MAP 5.3
R1881 4.9
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Enzyme
NAO 6.7
21-hydroxylase 6.6
PPH 6.3
3beta-hydroxysteroid dehydrogenase 5.3
HSD 5.2
meprin 5.1
BAT 4.5
prostaglandin synthetase 4.3
acyl-CoA oxidase 4.3
5alpha-reductase 4.1
5alpha-reductase 4.1
11beta-hydroxysteroid dehydrogenase 3.8
paraoxonase 3.4
paraoxonase 3.1
hormone-sensitive lipase 3.1
matrix metalloproteinase 9 3.1
furin 2.5
NADPH-diaphorase 2.2
phosphoenolpyruvate carboxykinase 2.1
phosphoenolpyruvate carboxykinase 2.1
phosphoenolpyruvate carboxykinase 2.0
ornithine decarboxylase 1.5
CYP3A4 1.5
ribonuclease 1.5
ribonuclease 1.5
GSK 1.4
lipoprotein lipase 1.4
tyrosine hydroxylase 1.3
carbonic anhydrase 1.3
beta-glucuronidase 1.3
pepsin 1.1
gamma-glutamyl transpeptidase 1.0
luciferase 1.0
CD10 0.9
superoxide dismutase 0.9
protein kinase 0.9
mitogen-activated protein kinase 0.8
monoamine oxidase 0.8
aspartate aminotransferase 0.8
glutathione peroxidase 0.8
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Compound
Clomiphene 10.6
Clomiphene citrate 10.3
Gonadorelin 9.7
Clomid 9.6
CFN 9.4
Infecundin 9.1
Cephapirin 9.0
FXM 8.9
Dianabol 8.1
Niridazole 7.9
Levonorgestrel 7.9
Norgestrel 7.8
Bromocriptine 7.7
Letrozole 7.6
Metformin 7.5
Metformin 7.5
Premarin 7.5
2-OHE1 7.5
2-keto-3-deoxygluconate 7.4
Androstenedione 7.2
Leuprolide 7.2
Cyproterone acetate 7.2
Danazol 7.1
17-OHP 6.9
o,p'-DDE 6.8
2-Methoxyestradiol 6.8
Androgen 6.3
Cabergoline 6.2
DPN 6.2
PGFM 6.1
Progesterone 6.0
Premarin 6.0
MBH 6.0
MEE 5.9
Alprazolam 5.9
benzyl benzoate 5.8
Estrogen 5.7
DIM 5.7
DHT 5.6
PAE 5.6
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