Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003128 (anovulation)
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Human Gene/Protein
DENND1A protein 12.2
RAB5B 11.6
DENND1A 10.9
C9orf3 10.6
PAPS synthase 2 10.6
WNT-4 10.3
STAR protein 9.8
LXRA 9.7
alpha-albumin 9.4
PRKAA 9.1
cytochrome P450c 9.0
P450C17 8.9
RAB5A 8.8
MSY2 8.8
LRF 8.7
LHCGR 8.7
THADA 8.7
BITE 8.7
thrombospondin-like 8.6
transgelin 2 8.4
connexin 37 8.4
CAPN10 8.4
sex hormone-binding globulin 8.4
UST 8.3
chorionic gonadotropin beta subunit 8.2
chemokine-like receptor 1 8.2
TOX3 8.0
INSR 7.9
ADAMTS1 7.9
ZFP36L2 7.9
Sulfite oxidase 7.8
luteinizing hormone receptor 7.8
MAP3K8 7.8
sex hormone binding globulin 7.7
human leukocyte antigen class II 7.7
FSH 7.7
PEPI 7.6
AMH 7.6
ANGPT1 7.5
follicle-stimulating hormone 7.5
ANGPT2 7.5
TNFAIP6 7.5
ZNF217 7.4
FSHR 7.4
bone morphogenetic protein 15 7.4
SLC16A1 7.3
AMHR2 7.3
SPO 7.3
growth differentiation factor 9 7.2
DHEAS 7.2
glycodelin 7.1
FGS 7.0
LHRH 7.0
follicle stimulating hormone receptor 7.0
follicle-stimulating hormone receptor 7.0
PRG 6.9
TTK 6.9
HCG 6.9
21-hydroxylase 6.9
SPK 6.9
ACACA 6.9
HSD3B2 6.8
P450c17 6.8
delta 4 6.8
CCND2 6.8
kisspeptin 6.7
LHbeta 6.7
Sex hormone-binding globulin 6.7
LPD 6.7
PRL 6.7
CYP19 6.6
GLP1 6.6
liver receptor homolog-1 6.6
USF2 6.6
Angiopoietin-2 6.5
CYP11A 6.5
glucose transporter 3 6.5
SULT2A1 6.5
RFRP 6.5
GATA-6 6.5
corticosteroid binding globulin 6.5
OTR 6.5
NOV 6.5
CYP19A1 6.4
L30 6.4
MLL2 6.4
FSH receptor 6.4
TRIM25 6.4
prolactin 6.3
aromatase 6.3
StAR 6.3
PG synthetase 6.3
ED3 6.3
FGF8 6.3
GH2 6.2
HSD3B1 6.2
TIE2 6.2
GDF9 6.2
FER 6.2
HOXA10 6.2
estrogen receptor 1 6.2
USF1 6.1
chorionic gonadotropin 6.1
CYP17 6.1
activator 1 6.1
Adenylyl cyclase 6.1
Resistin 6.1
CYP17A1 6.1
Wnt7a 6.1
Aromatase 6.1
angiotensin II type 2 receptor 6.0
IVF 6.0
complement component 3 6.0
AF-1 6.0
steroidogenic acute regulatory protein 6.0
MAPK3 5.9
estrogen-related receptor 5.9
STAR 5.9
HNF1A 5.9
Prolactin 5.9
CLN 5.8
IGF-binding protein 5.8
serine kinase 5.8
Period 1 5.8
CYP21A2 5.8
YAP1 5.7
LHR 5.7
CYP11A1 5.7
PPT 5.7
DRD3 5.7
gonadotropin deficiency 5.7
PIF 5.7
factor 9 5.7
Rubinstein-Taybi syndrome 5.6
FRG 5.6
steroidogenic factor-1 5.6
slim 5.6
5HT1A 5.6
TIS) 5.4
RED 5.4
neurokinin B 5.4
IRS-2 5.4
PPH 5.4
vitamin D binding protein 5.4
NPR-B 5.3
HSD 5.3
visfatin 5.3
inhibin alpha 5.3
MLP 5.3
glycogen synthase kinase 3 beta 5.3
TRH 5.3
IGFBP-1 5.3
ED2 5.2
thyrotropin-releasing hormone 5.2
PER2 5.2
NPR-A 5.2
SOCS 5.2
chemerin 5.2
smoothened 5.2
resistin 5.1
more...
Disease
Oligoovulation 14.2
dysfunction; endocrine 14.2
anovulation 14.2
Fear of pregnancy 12.6
Adrenal Cushing's syndrome 12.6
Anovulatory 11.6
hyperandrogenism 11.5
poor fetal development 11.2
polymenorrhea 11.1
Precocious pubarche 11.0
polycystic ovary syndrome 10.6
Androgen excess 10.5
Post-pill amenorrhea 10.3
ovarian dysfunction 10.3
endocrine disorder 10.2
Cervical erosion 10.2
nymphomania 10.2
Lactational amenorrhea 10.1
genital disorder 10.1
reproductive disorder 9.9
female subfertility 9.8
Hypothalamic amenorrhea 9.7
Endometrial atrophy 9.7
sexual dysfunction and infertility 9.7
Primary infertility 9.4
Premature adrenarche 9.3
amenorrhea 9.3
secondary amenorrhea 9.3
Subfertility 9.1
compulsive overeating 9.1
galactorrhea 9.1
galactorrhea 9.0
Genital tuberculosis 8.9
hyperprolactinemia 8.8
Retained placenta 8.8
Severe pre-eclampsia 8.6
endometrial hyperplasia 8.6
hypomenorrhea 8.5
metastatic endometrial cancer 8.5
Ovarian failure 8.5
luteoma 8.5
cystic ovary 8.4
Anorexia nervosa and bulimia 8.3
infertility 8.3
Ovary 8.1
hyperestrogenism 8.0
acanthosis nigricans 8.0
pelvic adhesions 7.9
DA3 7.8
hyperinsulinemia 7.7
Pseudopregnancy 7.6
acne 7.6
Androgen deficiency 7.5
Taybi 7.5
primary amenorrhea 7.5
puerperal infection 7.5
Ovarian hyperstimulation syndrome 7.4
metabolic syndrome X 7.3
Coronary artery calcification 7.2
adrenal cancer 7.2
ED3 7.1
ovarian cysts 7.1
Digestive Diseases 7.1
generalized tuberculosis 7.0
oligospermia 7.0
premature ovarian failure 7.0
polysubstance abuse 7.0
menopausal syndrome 6.9
VES 6.8
OCP 6.8
hypogonadism 6.8
Meadow 6.7
endometriosis 6.7
Sertoli-Leydig cell tumor 6.6
Sertoli-Leydig cell tumor 6.6
hypoactive sexual desire disorder 6.6
tubal pregnancy 6.6
congenital adrenal hyperplasia 6.6
PMT 6.6
granulosa cell tumor 6.5
premature menopause 6.5
fibrocystic breast disease 6.5
21-hydroxylase deficiency 6.5
salpingitis 6.4
metritis 6.4
Endometrium 6.4
Endometrium 6.3
adnexitis 6.3
adrenal hyperplasia 6.3
glucose intolerance 6.3
endometrial polyp 6.3
endometrial cancer 6.2
delayed puberty 6.2
prolactinoma 6.1
vaginal discharge 6.1
IVF 6.1
Subclinical hypothyroidism 6.1
metabolic disorder 6.1
familial disorder 6.1
HCG 6.0
Kallmann's syndrome 6.0
endometritis 6.0
dyslipidemia 5.9
precocious puberty 5.9
hypogonadotropic hypogonadism 5.8
transsexualism 5.7
Fallopian tube 5.6
abortion 5.6
premenstrual syndrome 5.6
uterine leiomyosarcoma 5.6
psychological disturbance 5.6
immaturity 5.6
emotional instability 5.5
endometrial adenocarcinoma 5.5
hydrosalpinx 5.4
metabolic syndrome 5.4
male infertility 5.4
genital infection 5.4
anorexia nervosa 5.3
ectopic pregnancy 5.3
premenstrual dysphoric disorder 5.3
Atrophic 5.3
Cushing's syndrome 5.3
mastopathy 5.3
obesity 5.3
hypertrichosis 5.2
Depressive disorders 5.2
Pituitary 5.2
ketosis 5.2
threatened abortion 5.2
SLS 5.2
fibrocystic disease 5.2
acne vulgaris 5.2
IRMA 5.1
hypercortisolism 5.1
SLS 5.1
overnutrition 5.1
hypercortisolemia 5.1
Sexual dysfunction 5.1
IGS 5.1
abdominal obesity 5.1
gestational diabetes mellitus 5.0
AGA 4.9
ED2 4.9
Addison's disease 4.9
pituitary adenoma 4.9
Nairobi 4.8
Addison's disease 4.8
gestational trophoblastic disease 4.8
pituitary tumor 4.8
psychoticism 4.8
gynecomastia 4.8
azoospermia 4.7
impotence 4.7
type 2 diabetes 4.6
adrenal adenoma 4.6
PMS 4.6
cervical dysplasia 4.5
DM2 4.4
Mastitis 4.4
more...
Symptom
ovulatory bleeding 10.6
Intermenstrual bleeding 10.2
reproductive problem 9.0
irregular bleeding 9.0
Vaginal dryness 9.0
menometrorrhagia 8.5
female puberty 7.3
male subfertility 7.1
physical symptom 6.2
hyperemesis 5.9
masculinization 5.9
mastalgia 5.6
menopausal symptoms 5.5
POA 5.1
overweight 4.9
pelvic pain 4.5
hot flashes 4.1
urinary frequency 4.0
physical appearance 3.6
photophobia 3.6
bloating 3.5
insomnia 2.4
anorexia 2.0
shortness of breath 1.8
nausea 1.7
myalgia 1.5
starvation 1.2
syncope 1.0
nausea and vomiting 0.9
discomfort 0.7
agitation 0.6
back pain 0.6
discomfort 0.6
fatigue 0.5
stigma 0.5
exhaustion 0.4
abdominal pain 0.2
vomiting 0.2
anesthesia 0.0
headache -0.0
analgesia -0.6
pain -0.6
seizures -1.1
Drug
Bravelle 11.0
Menotropins 10.7
Clomiphene citrate 10.3
Myo-Inositol 9.9
Gonadorelin 9.7
Humegon 9.5
Actos 9.4
Gonal-F 9.2
Actos 9.0
Gonal-F 9.0
Posilac 8.9
Terguride 8.6
Avandia 8.6
Lumiracoxib 8.6
Femara 8.2
Levonorgestrel 8.2
Deslorelin 8.1
Implanon 7.6
Ovulen 7.6
Premarin 7.5
Depo-Provera 7.4
Parlodel 7.4
FSH-beta 7.2
Luteinizing 7.1
Parlodel 7.0
HCG 6.9
2-Methoxyestradiol 6.8
Norplant 6.7
Norplant 6.5
NOV 6.4
Estrogens 6.4
Sulpiride 6.0
DHT 5.7
DHT 5.6
Orlistat 5.6
Rosiglitazone 5.5
Dihydrotestosterone 5.5
Finasteride 5.4
MAP 5.3
R1881 4.9
Isotretinoin 4.8
Raloxifene 4.7
Gelfoam 4.7
EE2 4.6
Diurnal 4.4
Prednisone 4.2
Ketoconazole 4.1
Aloe 3.9
Methylene blue 3.8
Cimetidine 3.5
Cimetidine 3.5
Activin 3.4
9-THC 3.4
p75 3.3
PCB 3.1
Dakar 3.1
ICI 2.8
Vitamin A 2.6
Growth hormone 2.6
ADM 2.6
Retinoic acid 2.4
CTX 1.7
CTX 1.7
PTH 1.4
ROC 1.3
ENT 1.1
Nephron 1.1
CTX 0.9
caffeine 0.8
Asn 0.7
ampicillin 0.1
NADH -0.2
lysine -0.7
Dermatol -1.5
Cardiovasc -3.4
Enzyme
NAO 6.7
21-hydroxylase 6.6
PPH 6.3
3beta-hydroxysteroid dehydrogenase 5.3
HSD 5.2
meprin 5.1
BAT 4.5
prostaglandin synthetase 4.3
acyl-CoA oxidase 4.3
5alpha-reductase 4.1
5alpha-reductase 4.1
11beta-hydroxysteroid dehydrogenase 3.8
paraoxonase 3.4
paraoxonase 3.1
hormone-sensitive lipase 3.1
matrix metalloproteinase 9 3.1
furin 2.5
NADPH-diaphorase 2.2
phosphoenolpyruvate carboxykinase 2.1
phosphoenolpyruvate carboxykinase 2.1
phosphoenolpyruvate carboxykinase 2.0
ornithine decarboxylase 1.5
CYP3A4 1.5
ribonuclease 1.5
ribonuclease 1.5
GSK 1.4
lipoprotein lipase 1.4
tyrosine hydroxylase 1.3
carbonic anhydrase 1.3
beta-glucuronidase 1.3
pepsin 1.1
gamma-glutamyl transpeptidase 1.0
luciferase 1.0
CD10 0.9
superoxide dismutase 0.9
protein kinase 0.9
mitogen-activated protein kinase 0.8
monoamine oxidase 0.8
aspartate aminotransferase 0.8
glutathione peroxidase 0.8
phosphatidylinositol 3-kinase 0.7
ERK 0.6
acid phosphatase 0.5
AMP-activated protein kinase 0.5
beta-lactamase 0.5
catalase 0.4
phospholipase A2 0.4
RNase 0.2
RNase 0.0
MEK 0.0
phosphodiesterase -0.0
adenylate cyclase -0.0
peroxidase -0.2
focal adhesion kinase -1.2
alkaline phosphatase -1.4
Compound
Clomiphene 10.6
Clomiphene citrate 10.3
Gonadorelin 9.7
Clomid 9.6
CFN 9.4
Infecundin 9.1
Cephapirin 9.0
FXM 8.9
Dianabol 8.1
Niridazole 7.9
Levonorgestrel 7.9
Norgestrel 7.8
Bromocriptine 7.7
Letrozole 7.6
Metformin 7.5
Metformin 7.5
Premarin 7.5
2-OHE1 7.5
2-keto-3-deoxygluconate 7.4
Androstenedione 7.2
Leuprolide 7.2
Cyproterone acetate 7.2
Danazol 7.1
17-OHP 6.9
o,p'-DDE 6.8
2-Methoxyestradiol 6.8
Androgen 6.3
Cabergoline 6.2
DPN 6.2
PGFM 6.1
Progesterone 6.0
Premarin 6.0
MBH 6.0
MEE 5.9
Alprazolam 5.9
benzyl benzoate 5.8
Estrogen 5.7
DIM 5.7
DHT 5.6
PAE 5.6
Vitamin D3 5.5
FTA 5.5
Vitamin D3 5.4
Estradiol 5.4
DHA 5.4
Tranexamic acid 5.4
PAPS 5.2
Insulin 5.2
ECP 5.1
TRH 5.1
RU-486 5.1
ECP 5.1
ECP 5.1
AF-2 5.1
Organon 5.0
Testosterone 5.0
Testosterone 4.9
Raloxifene 4.8
Estrogen 4.8
DHPG 4.7
prostaglandin F2alpha 4.7
Quinidine 4.6
cholestane 4.6
cholestane 4.6
cholestane 4.6
3-methylhistidine 4.6
Inositol 4.5
Pentoxifylline 4.5
PMS 4.5
POA 4.5
DOPAC 4.3
AGE 4.2
Ketoconazole 4.2
Hypo 4.2
Valproic acid 4.2
ACTH 4.2
Estate 4.2
CdCl2 4.1
Wortmannin 4.0
MAP 4.0
TSH 4.0
Coenzyme Q10 4.0
PPA 3.8
MPA 3.8
MPA 3.8
MPA 3.7
DEHP 3.6
Thyroxine 3.6
L-threonine 3.6
2-ethylhexyl 3.6
2-ethylhexyl 3.6
2-ethylhexyl 3.6
vinyl acetate 3.6
Prednisone 3.5
Melatonin 3.5
Adrenal 3.4
ubiquinol 3.4
Tamoxifen 3.4
Tamoxifen 3.3
Cortisol 3.3
Methylene blue 3.3
phthalic acid 3.2
diacetate 3.1
APS 3.1
DHA 3.1
MTX 3.1
Bisphenol A 3.0
DHA 3.0
Bisphenol A 3.0
coenzyme Q10 3.0
6-12 3.0
Norepinephrine 2.8
Phosphatidylinositol 2.8
PAP 2.8
DDD 2.7
glucose 2.7
Vitamin A 2.6
PLA 2.6
PAP 2.5
PAP 2.5
ICI 2.5
Vitamin D 2.5
BMD 2.5
PAP 2.5
Serine 2.5
Valproic acid 2.5
sulfate 2.4
SCN 2.4
Naloxone 2.3
Abbott 2.3
Tween 80 2.3
Prostaglandin 2.3
Prostaglandin 2.3
DBP 2.3
homocysteine 2.2
Primatol 2.2
Primatol 2.2
THE 2.2
alloxan 2.2
Dopamine 2.1
DBP 2.1
Primatol 2.1
Resveratrol 2.1
acetate 2.0
C-3 1.9
Cholesterol 1.9
Methotrexate 1.9
Thyroid 1.9
creatinine 1.8
DDT 1.7
cAMP 1.5
vanadium 1.4
palmitic acid 1.4
Hemoglobin 1.4
A 3 1.3
Clin 1.1
CAT 1.0
CAT 1.0
chromium 1.0
L-DOPA 1.0
more...