Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003128 (anovulation)
 1,718 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After being suspected in the presence of galactorrhoea, it is now easy to prove hyperprolactinism thanks to radioimmunoassay of prolactin. The repercussions of hyperprolactinism on gonad function are now well known, especially in women where they lead to anovulation then amenorrhoea, whereas in man there occurs hypoandrogenism with loss of libido. Hyperprolactinemia may occur in numerous circumstances and may be deduced logically from the mechanism of secretory regulation of this hormone. Among the latter, one cause dominates the others by its therapeutic consequences, I.e. the presence of an adenoma or microadenoma secreting prolactin discovered thanks to tomography of the sella turcica. The treatment of hyperprolactinism has advanced in recent years with the introduction of dopamineric drugs such as bromcriptin which permits one to normalise prolactinemia and thus restore gonad function. It's use requires however certain precautions and neurological and ophthalmic supervision when htere is a microadenoma.
Sem Hop 1977 Jun 23
PMID:[Hyperprolactinism and antiprolactin drugs]. 19 33

The first problem is one of definition : the menopause coincides in time with the arrival of anovulation and the disappearance of the menses ; the premenopause is characterised by irregularity of the cycles and the secretion of estrogens by the internal theca ; the perimenopause covers the entire period of the premenopause and the menopause itself. The second aspect considered is social and demographic : the average age seems to be rising (nowadays 52 years of age) but this is more an impression than a certainty ; in 1972, it was estimated that there were three million women undergoing the perimenopause in France ; finally, it would be easier for women to come through the menopause, if, at that age, they were entrusted with social responsibilities to fill their leisure time. A final problem relates to the understanding of the physiopathological factors involved. The growing insensitivity of the ovary and the consequent hormonal changes are well known, but the hypothalamo-pituitary axis remains intact and it is beginning to be thought that complex catecholamine interactions may be involved at this level. The complexity of hormonal balances and the varied effects of hormones and their derivatives suggest that much might be gained from studying the possibility of estrogen therapy.
Sem Hop
PMID:[The menopause and its problems (author's transl)]. 625 24