Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003123 (anorexia)
 13,794 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cyclosporin A was given to five patients with acute leukaemia in whom graft-versus-host disease (G.V.H.D.) had developed after bone-marrow transplantation from sibling donors. In all instances the acute erythematous skin reaction of G.V.H.D. resolved within two days, but four of the five patients died. Cyclosporin A in high doses produced anorexia, nausea, and a reversible rise in blood-urea. The four patients who died all had liver damage, but the histological changes varied. Cyclosporin A modifies the acute skin reaction of G.V.H.D. In the management of liver and gut G.V.H.D., and in prophylaxis of G.V.H.D., its role needs to be determined.
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PMID:Cyclosporin A for the treatment of graft-versus-host disease in man. 8 37

Clinical findings and histopathological appearances in the patients with cancer of the head and neck treated with a new anti-tumor agent, pepleomycin, are reported. The total dosage of the new drug was within 100 mg on the average; however, the responses to chemotherapy were considerably favorable in general. Pepleomycin was markedly effective in two patients, moderately effective in seven, and ineffective in one. Microscopic evidences of regression of cancer cells were demonstrated in six surgical materials. Pepleomycin was shown to have an even more selective action on squamous cell carcinoma than bleomycin. The reactions of the surrounding tissue and skin to combination therapy, including pepleomycin, remained comparable to those to bleomycin. Side effects of the drug were slight fever and transient anorexia. No fibrosis of the lung was seen during eight months of observation.
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PMID:[Histological appearances of cancer of the head and neck treated with pepleomycin (NK 631) (author's transl)]. 8 1

The comparative studies in the short term intermittent toxicity of pepleomycin (NK631) and bleomycin (BLM) were performed on 10 beagle dogs of 13 approximately 15 months old. Two dogs per group were injected intravenously with NK631 and BLM in doses 5.0 and 2.5 mg/kg body weight every fourth day for 11 treatment. Two dogs served as control and were injected with saline solution. In the group of 5.0 mg/kg of NK631, one dog was sacrificed on day 37 of the treatment and another one dog died on day 33 of the treatment. All the dogs of other group survived until the end of the treatment. The toxicity to the hepatic and renal damage caused by NK631 was stronger than the BLM. On the contrary, the toxicity to lung and various mucocutaneous regions was weaker than the BLM. The grade of pulmonary fibrosis of NK631 was about 1/2 and 2/3 of the BLM in dose of 5 mg/kg and 2.5 mg/kg, respectively. Other toxicological changes such as anorexia and weight loss were almost similar to the BLM.
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PMID:[Toxicological studies of pepleomycin sulfate. V. Short term intermittent toxicity in dogs (author's transl)]. 8 8

Drugs found in a woman's blood can be detected in her milk. The concentration in milk depends on the amount of drug in maternal blood, its lipid solubility and degree of ionization, whether it is actively secreted into the milk, and status of maternal renal function. Alcohol concentration in the mother's milk is generally about equal to that in her blood; it is not known however, how large a daily dose can be tolerated by an infant. Anticoagulants may or may not appear in breast milk. No significant side effects on the infant have yet been reported. Anticonvulsants generally do not affect infants, but some cause drowsiness and in one case, methemoglobinemia. Antihypertensive drugs such as reserpine may cause increased respiratory tract secretions, nasal congestion, cyanosis, and anorexia in breastfed infants, but others do not cause adverse side effects on the nursing infant. Antimicrobial, antithyroid, contraceptive hormones, norcotics, sedatives and psychiatric drugs, and caffeine cause minor and serious side effects on nursing infants. Generally, nursing mothers should refrain from taking drugs whenever possible. Those who must take antithyroid drugs (especially radioactive iodine), lithium, chloramphenicol and most anticancer drugs should not nurse. The side effects of many other drugs in breast milk are not known.
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PMID:Update: drugs in breast milk. 8 32

A hospice-care program offers an opportunity to provide effective palliative care for patients terminally ill with malignant disease and to develop improved methods for coping with the problems of the dying patient. All patients for whom antitumor therapy does not offer a reasonable possibility of cure are eligible for Church Hospital's multidisciplinary program, the focus of which is on both the patient and his family. Acceptance by medical staff, patients and families has been enthusiastic. Both conventional and unconventional methods can be helpful in making terminally ill patients more comfortable. Much has been learned about the control of pain in such patients. Intestinal obstruction can often be managed non-operatively without the use of nasogastric tube. Other common symptoms such as weakness, anorexia, depression, dyspnea, etc. can be relieved with varying degrees of success. An objective of the program is to allow the patient to be at home for most of his terminal illness and to die there if possible. By utilizing patient and family instruction, visiting nurses and home health aides, approximately two-thirds of the patients in the program at any given time are at home. Basing the program in an acute care hospital has allowed coordination with the curative treatment of malignant disease and effective use of radiation and chemotherapy for palliative purposes. The organizational structure, financing, facilities and clinical experience with 100 consecutive patients of the Church Hospital hospice-care program are described.
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PMID:Experience with a hospice-care program for the terminally ill. 8 9

A review of the case histories of 345 patients who underwent protatectomy showed that 1.7 percent (6 patients) had "occult and progessive renal damage" secondary to prostatic hypertrophy. All these men were over the age of 60 and the disturbances in micturition were so mild that the patients were unaware of, or chose to ignore them. The presenting symptoms were nonspecific and included generalized weakness, anorexia, nausea, constipation, and weight loss. Investigation revealed impaired renal function of varying degrees. Prostatectomy was associated with a dramatic improvement in all 6 patients. Physicians should be aware of the clinical entity of occult and progressive renal damage secondary to obstruction of the bladder outlet, especially in the elderly male. Uremia can develop with minimal urinary symptoms. Elderly men often suppress or deny their symptoms because of the fear of operation.
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PMID:Occult progressive renal damage in the elderly male due to benign prostatic hypertrophy. 8 33

It is impossible to accurately evaluate NK 631 as an anticancer agent from the findings only in the 7 cases; hence, the following is no more than the author's impression about the drug. However, NK 631 appeared to exert a similar anticancer effect to the currently available bleomycin. In other words, the drug will completely cure or greatly improve the early cases of squamous cell carcinoma, and bring about a transient regression in the advanced cases. The response of malignant lymphoma to this drug varied from case to case; in any event, it is impossible to anticipate a complete cure in this malignancy by single NK 631 therapy but by multiple combination chemotherapy, e.g., BEMP therapy. The adverse reactions to NK 631 that were observed included pulmonary fibrosis, though only in 1 case; hence, no conclusive opinion should be given herein about it pulmonary toxicity in comparison with the pulmonary toxicity of bleomycin. It remains a theme of the future statistic studies in a large number of cases. The other adverse reactions were anorexia and mild alopecia in some of the cases, which were similar to those to bleomycin. Pigmentation also occurred in one of the cases, but the author was impressed that this reaction was less likely to occur with NK 631.
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PMID:[Clinical application of NK 631, a new derivative of bleomycin (author's transl)]. 9 Jul 42

A case of Whipple's disease with central nervous system (CNS) involvement has been retrospectively diagnosed. At the age of 50 and after six years of recurrent bouts of pyrexia, anorexia and loss of weight, a man developed a subacute encephalitis. Two episodes of acute loss of vision were followed by changes in mental status, supranuclear ophthalmoplegia and oculo-facio-cervical myorhythmias which remained present until death, one year later. Combined light- and electron microscopic studies have demonstrated: No. 1 the presence in the CNS of nodules containing large amounts of Sieracki cells; No. 2 the existence of bacteria in various stages of degeneration in macrophages or in the neuropile. A review of CNS complications in Whipple's disease is made.
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PMID:Cerebral manifestations of Whipple's disease. 9 79

Three cases of severe anorexia are reported. It results in a strong protein malabsorption with hepatic steatosis and in a syndrome of mental depression which needed the re-establishment of the intestinal-continuity. Although a mild post-operative anorexia is regular and contributes to the weight loss, massive anorexia must be considered as a new and redoubtable unpredictible complication of the surgical treatment for obesity, which may hinder the intestinal adaptation and increase the protein malabsorption.
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PMID:[Anorexia: a redoubtable complication of the surgical treatment for obesity after jejuno ileal by-pass (author's transl)]. 9 23

During a 20-month period all acute nonlymphocytic patients (87 patient trials) receiving cytotoxic chemotherapy were placed on an oral nonabsorbable antibiotic regimen consisting of gentamicin, vancomycin, and nystatin in addition to an intensive program of infection prevention aimed at reducing exogenously acquired and body-surface potential pathogens. Although side effects of anorexia, diarrhea, and nausea were common, gentamicin-vancomycin-nystatin was ingested 80% of the study time. Microbial growth in gingival and rectal cultures was substantially reduced. The incidence of bacteremias and other serious infections was low. Pseudomonas aeruginosa, other gram-negative bacilli, and Candida species caused few infections along the alimentary canal, whereas infections of the skin (especially Staphylococcus aureus) were not reduced compared with those occurring in former years. A total of the 104 acquired gram-negative bacilli were gentamicin resistant; 5 subsequently caused infection. Thus, despite certain definite drawbacks, the use of oral nonabsorbable antibiotics to suppress alimentary tract microbial flora in combination with other infection prevention techniques in granulocytopenic cancer patients has proven feasible and tolerable and has been associated with a low order of life-threatening infections.
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PMID:Infection in acute leukemia patients receiving oral nonabsorable antibiotics. 9 7


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