Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003090 (arthrodesis)
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Human Gene/Protein
AARF 11.9
cell division cycle 7 homolog 11.9
SYM1 10.7
ANKH 9.8
progressive ankylosis protein 9.7
CPNE7 8.3
HLAB 8.3
MAB21L2 8.2
ANK 8.1
TRIP11 8.0
cdc25C protein 7.9
WZS 7.8
B2A 7.5
phosphatidylinositol binding clathrin assembly protein 7.4
NPP1 7.4
MOP3 7.4
FLNB 7.3
CHM1 7.1
swan 7.1
FOP 7.1
GNAI3 7.0
MTP1 7.0
SZP 7.0
CMC1 6.9
parathyroid hormone receptor 1 6.9
ACVR1 6.9
STEAP4 6.8
SLC4A2 6.7
ankylosing spondylitis 6.7
MTP 6.7
parathyroid hormone-like hormone 6.6
HAPLN1 6.6
DIP 6.6
HEBP 6.6
DEL1 6.5
PCNT 6.5
ENPP1 6.4
GDF5 6.4
PHOSPHO1 6.4
TNAP 6.4
LDE 6.4
tissue-nonspecific alkaline phosphatase 6.3
PLCB4 6.2
Ste24p 6.2
activin receptor-like kinase 2 6.2
enamel matrix protein 6.1
filamin B 6.1
BONE 6.1
type XII collagen 6.1
Fez 5.9
dendritic cell immunoreceptor 5.9
PQBP1 5.9
ARTS 5.9
TESS 5.8
PIP 5.7
asporin 5.7
LCP 5.6
MEPE 5.6
HLA-B27 5.5
DLX6 5.5
noggin 5.5
ROM 5.4
ZNF 5.4
ANTXR2 5.4
MAP3 5.4
MIS 5.4
TKR 5.3
JPS 5.3
EVC 5.3
ITGAV 5.2
MIO 5.2
B27 5.2
PC-1 5.1
PRC 5.1
ZMPSTE24 5.0
TMEM16F 5.0
SMAD5 5.0
Facioscapulohumeral muscular dystrophy 4.9
OP2 4.9
X-box-binding protein 1 4.9
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Disease
arthrodesis 11.9
syndrome; cervical 11.9
Sacroiliac ankylosis 11.9
Carpitis 11.9
Diabetic arthropathy 11.9
CCAL2 11.2
Romanus lesion 11.2
Bony ankylosis 11.0
Cervicobrachial neuralgia 10.9
SYM1 10.8
Tooth ankylosis 10.6
osteoarthritis of the wrist 10.4
CCAL1 10.3
Pseudoankylosis 10.3
Carpal collapse 10.1
Ankle osteoarthritis 9.9
Bone sequestration 9.9
cardiocranial syndrome 9.9
Chronic osteoarthritis 9.7
multiple synostoses syndrome 9.6
Tarsal coalition 9.6
Vesicocutaneous fistula 9.6
Craniometaphyseal dysplasia 9.2
Charcot arthropathy 9.2
Kienbock's disease 9.1
Otospondylomegaepiphyseal dysplasia 9.1
Juvenile ankylosing spondylitis 9.1
ruptured disk 9.1
Chronic polyarthritis 9.1
Lethal multiple pterygium syndrome 9.1
Cervical spinal cord compression 9.1
Talocalcaneal coalition 9.1
Arthritis mutilans 9.1
Isthmic spondylolisthesis 9.0
Mandibular retrognathism 8.9
Degenerative spondylolisthesis 8.9
Skin flap necrosis 8.7
Nail deformities 8.7
Laryngeal web 8.6
CACP 8.6
hypercementosis 8.6
arthritis of the wrist 8.6
Secondary osteoarthritis 8.3
Bacteroides infection 8.3
Tuberculous dactylitis 8.3
Primary osteoarthritis 8.3
prenatal disorders 8.2
Fungal arthritis 8.2
Hanhart 8.2
spondylolisthesis 8.1
Neuromuscular scoliosis 8.0
sacroilitis 7.9
arthritis of the hip 7.9
algoneurodystrophy 7.9
Grisel's syndrome 7.9
monarticular arthritis 7.9
Baastrup 7.8
incomplete quadriplegia 7.8
capsulitis 7.8
pseudocroup 7.7
Metal allergy 7.7
enthesopathy 7.7
noma 7.7
chondrolysis 7.7
Erosive osteoarthritis 7.6
Dysosteosclerosis 7.6
Fibrodysplasia ossificans progressiva 7.6
coxitis 7.6
mallet finger 7.6
Pfeiffer syndrome 7.5
TMJ 7.5
cartilage disorder 7.5
sesamoiditis 7.5
sacroiliitis 7.5
Peroneal nerve palsy 7.4
arthropathy 7.4
hydroxyapatite deposition 7.3
Wildervanck syndrome 7.3
enthesitis 7.3
Prosthetic joint infection 7.2
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Symptom
Sacroiliac joint laxity 11.9
Lateral femoral cutaneous neuralgia 11.9
metatarsalgia 8.8
lumbar instability 8.4
Hyperflexion 8.2
wrist pain 7.7
side pain 7.7
Flail 7.5
toe pain 7.4
musculoskeletal disability 7.4
Localized pain 7.2
pain in the buttock 7.2
ankle pain 7.2
Hyperextension 7.1
feeling sick 7.0
distraction 6.9
musculoskeletal impairment 6.5
Halo 6.2
Opposition 6.2
Pain symptoms 6.1
heel pain 6.0
joint stiffness 5.9
Cold intolerance 5.8
Pain at rest 5.5
lumbar back pain 5.5
Spastic 5.4
Stiffness 5.4
leg pain 5.4
respiratory problem 5.2
hand pain 5.2
nerve pain 5.1
No pain 5.1
inanition 5.1
abnormal gait 5.1
back pain 5.0
sciatica 5.0
neck stiffness 5.0
torticollis 4.9
arthralgia 4.9
neck pain 4.9
hyperesthesia 4.8
knee pain 4.8
clumsiness 4.8
collapse 4.7
low back pain 4.7
pain 4.7
Severe pain 4.6
Flare 4.4
hip pain 4.4
Postoperative pain 4.4
aphonia 3.9
arm pain 3.9
spasticity 3.9
paraparesis 3.8
dark urine 3.8
paresis 3.6
snoring 3.6
paresthesia 3.4
clonus 3.4
chronic back pain 3.3
stridor 3.3
hemiplegia 3.3
functional recovery 3.2
hoarseness 3.2
neuralgia 3.1
loss of balance 3.1
discomfort 3.1
dysesthesia 3.0
orofacial pain 3.0
discomfort 2.9
weakness 2.9
physical appearance 2.9
hypersomnia 2.9
swollen joints 2.8
thigh pain 2.5
limb pain 2.5
groin pain 2.3
rigors 2.2
spasm 2.2
numbness 2.1
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Drug
A.P.L. 9.1
OP-2 7.8
Surgibone 7.6
EPL 6.1
PDL 5.9
Naprosyn 5.6
Polyurethane foam 5.2
Marcaine 5.2
SnF2 5.0
Adalimumab 4.8
Norplant 4.8
Saha 4.8
Infliximab 4.6
Infliximab 4.6
THA 4.4
Ethane 4.2
Xylocaine 4.2
Singular 3.9
Arthrex 3.9
Xylocaine 3.9
Zmax 3.9
CLS 3.7
CPM 3.7
IPD 3.7
Xylocaine 3.5
SPP 3.3
Doyle 3.2
Bosentan 3.2
Bosentan 3.2
Hyaluronidase 3.1
CVA 3.0
EHDP 2.9
Hyaluronidase 2.9
Vicryl 2.8
p75 2.6
Gelfoam 2.4
citric acid 2.3
Posture 2.3
CDP 2.3
Android 2.3
Aprotinin 2.1
CAM 2.0
PFA 1.9
Ketoconazole 1.9
Dakar 1.8
AMC 1.7
Horizon 1.7
Azithromycin 1.6
balanced salt solution 1.3
Activin 1.2
MRC 1.2
TTC 1.0
Frontal 0.9
Fragment 0.7
Adriamycin 0.7
Ringer's solution 0.4
Vitamin A 0.3
Indomethacin 0.3
PTH 0.2
PCP 0.0
G-CSF -0.5
Leaf -0.5
ampicillin -0.6
Monit -0.9
EE2 -1.0
Spectrum -1.1
ENT -1.2
nitroglycerin -1.2
ascorbate -1.6
MAP -2.0
IFN-gamma -2.9
CSF -3.0
Dermatol -4.1
Cardiovasc -4.7
Enzyme
PHOSPHO1 6.4
polyphosphatase 5.1
nucleotide pyrophosphatase 4.9
HOA 4.9
TMT 4.9
alpha-L-iduronidase 4.4
homogentisate 1,2-dioxygenase 4.3
CPM 3.5
MCS 3.3
Protein 2 3.1
MDP 2.8
CCS 2.7
CAD 2.4
CAD 2.4
CAD 2.3
SST 2.3
SPS 2.2
SCS 1.9
nucleotidase 1.9
alkaline phosphatase 1.6
purine nucleoside phosphorylase 1.4
CPT 1.3
CPT 1.1
cathepsin G 1.1
prostaglandin synthetase 1.0
cathepsin K 1.0
PAM 1.0
phosphodiesterase 0.9
CPT 0.7
STR 0.3
MMP-3 0.2
PCP 0.0
neutrophil elastase -0.1
collagenase -0.3
hyaluronidase -0.3
transcriptase -0.3
proteasome -0.3
AST -0.7
hyaluronidase -0.7
aldehyde dehydrogenase -0.8
MAP -1.0
APC -1.1
guanylate cyclase -1.2
elastase -1.3
ACE -1.3
CD10 -1.4
ERK -1.5
urokinase-type plasminogen activator -1.5
beta-lactamase -1.8
neuraminidase -1.9
NO synthase -2.1
thrombin -2.1
RNA polymerase -2.2
creatine kinase -2.3
luciferase -2.3
aspartate aminotransferase -2.5
focal adhesion kinase -2.5
alanine aminotransferase -2.8
ATPase -3.1
protein kinase -3.4
trypsin -3.5
catalase -3.9
peroxidase -4.1
Compound
EPB 6.8
BTO 6.5
Calcium hydroxide 6.3
Ponceau S 5.4
Fludrocortisone 5.0
T11 4.8
TFF 4.7
Sulfasalazine 4.7
C56 4.4
Coronal 4.3
HAQ 4.3
Etanercept 4.2
Silver, 4.2
Naproxen 4.2
PPi 4.1
Geigy 4.0
iodoform 4.0
titanium 3.9
CLS 3.9
tetrahydrothiophene 3.8
IPD 3.7
T10 3.7
TEP 3.7
MCP 3.5
THE 3.5
DBM 3.4
TCP 3.4
TCP 3.4
DBM 3.4
TCP 3.3
TCP 3.3
SSD 3.3
PPF 3.2
Alizarin Red S 3.2
EHDP 3.2
MTS 3.1
EOS 3.1
MNA 3.0
MNA 3.0
Cortisone 3.0
BAS 3.0
FDP 3.0
Triptolide 2.9
NFS 2.9
Sphingosine 1-phosphate 2.9
AME 2.9
Austin 2.8
MTA 2.8
PVP-I 2.8
T13 2.7
Bantu 2.7
A 3 2.7
Chlorhexidine 2.7
CCS 2.6
TMC 2.5
Streptomycin 2.4
PPI 2.4
HAP 2.4
DIM 2.4
Amikacin 2.3
Lea 2.3
Levamisole 2.3
6-12 2.3
Polypeptide 2.2
HVA 2.1
hydroxide 2.1
MVA 2.0
Bordeaux 2.0
CDA 2.0
Gentamicin 2.0
Collagenase 1.9
MEP 1.9
Ketoconazole 1.9
CPP 1.8
Fibrin 1.8
MEP 1.8
CPP 1.8
Alizarin 1.7
DMD 1.7
Lidocaine 1.7
more...