Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0003090 (arthrodesis)
 8,374 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to study in detail the processes leading to the resorption and ankylosis of teeth after trauma, the effects of cold application on the periodontal tissues were studied in the mouse. Liquid nitrogen was applied locally to the outer surface of the lower jaw which resulted in a freezing of the incisor and its surrounding tissues. The healing processes in the damaged periodontal ligament and the accompanying phenomena of ankylosis and dental root resorption were investigated histologically at both the light and electron microscopic levels. As a result of cold application, the cells in the periodontal ligament were killed. After a few days, the ligament started to be repopulated with cells like fibroblasts and macrophages. From 3 days on, mineral crystallites were deposited along the cementum covering the lingual, mesial, and lateral surfaces of the incisor, finally resulting in a 4-6 micron thick layer. During the period of 7-12 days following cold application, this layer of mineralized material started to be phagocytosed and degraded, presumably by mononuclear cells. Finally, extensive root resorption and some ankylosis between the tooth and the alveolar bone were observed. In the resorbed areas, cells were seen which could not be distinguished from osteoclasts. In some instances, their ruffled border was in close apposition with each of the three mineralized tissues--dentin, cementum, and alveolar bone. It is hypothesized that the deposition and subsequent phagocytosis of mineralized material along the root surface may be an important factor in the initiation of dental root resorption.
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PMID:Resorption of the mouse incisor after the application of cold to the periodontal attachment apparatus. 308 60

The Bone bank at the University Clinic is described along with its three units: Electrical freezer (-40 degrees). Liquid nitrogen freezer (-197 degrees). Temperature programmer descend. The first unit is used for the preservation of cancellous bone, for a limited lapse of time; the second unit is employed for preserving cortical grafts for an unlimited period. The third unit allows to control the temperature descend rate, in order to preserve the viability of chondrocytes in grafts including epiphyseal ends. Clinical applications of bone grafts are currently enlarging in areas such as tumour surgery, spine surgery and arthrodesis and reconstructive procedures of the hip joint.
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PMID:[The bone bank of the University Clinic in Navarra]. 332 33

The effect of cryopreservation in liquid nitrogen at -196 degrees C for 1 week was studied by histometric analysis of 60 mature teeth replanted in 10 green Vervet monkeys. The effect of preincubation in enriched tissue culture medium was also investigated. 2 different freezing rates were compared, and the effect of stepwise equilibration of DMSO was studied as well as the effect of root canal treatment. The histometric analysis carried out 8 weeks after replantation revealed that if the cryoprotectant was equilibrated stepwise at room temperature, 10% DMSO had an even better cryoprotecting effect than previously shown by 5% DMSO equilibrated at 0 degree C. When this procedure was combined with a slow freezing rate of 0.3 degree C/min from -4 degrees C to -35 degrees C followed by plunging in liquid nitrogen, and supplemented by endodontic treatment before replantation, the amount of normal periodontal healing was almost similar to unfrozen and immediately replanted control teeth. Furthermore, this cryoprofile induced replacement resorption equal to the replanted control teeth. Preincubation in enriched medium for 24 h did not reduce resorption activity of the periodontal ligament. Endodontic treatment reduced the inflammatory resorption, demasking, however, hereby limited amount of ankylosis, that could be reduced by the above-mentioned cryoprofile. An optimal cryoprofile for mature teeth seemed to be slow equilibration at room temperature to a final concentration of 10% DMSO, slow freezing rates (0.3 degree C/min) and plunging in liquid nitrogen at -35 degrees C combined with fast thawing after storage at -196 degrees C, and followed by endodontic treatment after thawing.
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PMID:Cryopreservation before replantation of mature teeth in monkeys. (II). Effect of preincubation, different freezing and equilibration rates and endodontic treatment upon periodontal healing. 392 11

Nonspecific low back pain has long been a troublesome clinical entity in that the diagnoses are usually hard to define, and the effect of treatment unsure. We have been conducting long-term basic and clinical research in Zhujiang Hospital in an effort to find the exact mechanism for this disease and to explore its causal treatment. On the basis of literature review and treatment result evaluation, we recommend the following approaches for origin-specific diagnosis and treatments: (1) For spinal nerve dorsal ramus syndrome caused by mechanical stimulation on the stem part of the dorsal ramus, freezing the dorsal ramus with liquid-nitrogen may constitute the primary treatment. (2) In cases of low back pain originated from the lumbar disc due to degeneration of discs, treatment may be implemented through disc resection with or without arthrodesis. (3) Facet syndrome, a condition with low back pain that is seldom caused by pathological changes in the facet itself, but mostly by the pulling of the dorsal ramus due to the dislocation of the facet, should be attributed to the dorsal ramus syndrome. (4) Lumbar vertebra instability arising from loosened intervertebral conjunction calls for arthrodesis as the primary choice. (5) Interspinal ligaments injury can be most effectively treated by the combination of blocking and needle knife loosing. (6) Low back pain with underlying causes in the internal organs is often caused by diseases in the pelvic organs, and only these diseases are cured can the back pain be relieved. These origin-specific diagnosis and treatments we proposed here await further investigation and comments from our peers interested in this problem.
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PMID:[Cause-specific treatment for nonspecific low back pain]. 1248 May 73

Giant cell tumors of the distal radius have been frequently described as difficult to treat, chiefly because of their close proximity to multiple tendons, median nerve, radial artery and carpus.The aim of treatment is to remove the tumor completely and preserve the radiocarpal and radioulnar joints.However, this is not always feasible as giant cell tumors seem to behave more aggressively and have a higher recurrence rate in the distal radius, even if local adjuvant treatment with phenolmethylmethacrylate or liquid nitrogen is applied. The above incidence is increased in Campanacci grade III lesions, which are characterized by fuzzy borders, loss of cortical continuity, and extension into soft tissues. In these cases, wide excision instead of intralesional excision may be advocated, particularly when the tumor breaks through the cortex, violates the articular surface, and destroys >50% of the surrounding metaphysis. Several reconstructive options (e.g., resection arthroplasty, prosthetic replacement, arthrodesis, ulnar translocation, centralization of the carpus over the remaining ulna, use of a nonvascularized, or vascularized fibular graft [with or without arthrodesis], and allograft replacement) have been described for the treatment of either recurrent or primary grade III giant cell tumor with destruction of the bone cortex and associated soft tissue mass. Ulnar translocation has been mentioned rarely in the literature, and, according to our knowledge, only 10 cases have been previously reported. This article presents a case of a woman with a grade III giant cell tumor of the distal radius. Wide excision of the tumor followed by reconstruction of the distal forearm with a modified ulnar translocation technique and wrist arthrodesis led to optimum results and no mass recurrence at 13 years postoperatively.
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PMID:Modified ulnar translocation technique for the reconstruction of giant cell tumor of the distal radius. 1929 37