Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002986 (Fabry)
 5,646 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
X-linked 597
alpha-galactosidase A 526
Sep 407
alpha-galactosidase 395
Mol 209
Gal 185
GLA 179
X-linked recessive 101
ACS 52
MRI 52
hole 51
vascular endothelium 51
fused 38
endoplasmic reticulum 28
chronic renal failure 27
She 27
glucocerebrosidase 25
alpha-N-acetylgalactosaminidase 24
GAL 24
X-chromosome 20
ESX 20
lamp 20
CCD 19
MPS II 19
collagen 18
trip 18
glucosylceramide synthase 17
alpha-L-fucosidase 17
GFR 17
sky 15
glycoprotein 13
asymmetrical 13
Pol 12
sarcomeric 12
Alport syndrome 12
axonal 11
glucosidase 11
hemoglobin 11
membrane-bound 10
MPS VI 10
IgE 10
C18 9
corneal dystrophy 9
insulin 9
PON 8
endothelial nitric oxide synthase 8
ESI 8
MIM 7
cytokine 7
cardiac muscle 7
SMF 7
CD34 7
imiglucerase 7
CADASIL 7
beta 1 7
serum albumin 6
lectin 6
PBF 6
NMR 6
AGA 6
cryptic 6
mannose-6-phosphate receptor 6
HEK 6
renin 6
CO2 6
chitotriosidase 6
Men 6
lymphoid 6
natriuretic peptide 6
alpha-glucosidase 6
albumin 6
COL4A1 6
hemochromatosis 6
twist 6
polypeptide 6
CD4 5
angiotensin receptor 5
acid alpha-glucosidase 5
alpha-mannosidase 5
mannose 6-phosphate receptor 5
LAMP2 5
CD1d 5
peroxidase 5
uromodulin 5
alternatively spliced 5
threonine 5
TOF 5
beta-glucuronidase 5
FPL 5
NAGA 5
acid phosphatase 5
TNF 5
Gb3 synthase 5
endonuclease 5
sodium channel 4
CD172a 4
Mal 4
megalin 4
dilute 4
PAM 4
PRKAG2 4
transferrin 4
LDL receptor 4
lysosomal acid lipase 4
superoxide dismutase 4
CSF 4
aspartylglucosaminidase 4
SOD 4
CD31 4
GAA 4
ANOVA 4
OCT 4
factor V Leiden 4
hexosaminidase A 4
TEM 4
TLR4 4
LC3 4
X-linked adrenoleukodystrophy 4
troponin T 4
interleukin-6 4
synuclein 3
galactosyltransferase 3
lysosomal protein 3
KCa3.1 3
androgen receptor 3
AFM 3
transthyretin 3
HLA 3
ISA 3
TRPV1 3
MELAS 3
eNOS 3
sortilin 3
SPP 3
proximal tubule 3
SARS 3
GAT 3
intercellular adhesion molecule-1 3
HCN 3
HDL 3
IVA 3
acid sphingomyelinase 3
ALD 3
chemokine 3
MDR1 3
Protein A 3
nodal 3
IL-4 3
FUCA1 3
von Willebrand factor 3
CD19 3
Sp1 3
LCAT 3
nitric oxide synthase 3
JAMA 3
LAMP-2 3
NIR 3
GBS 3
Spin 3
TRPML1 3
more...
Disease
Fabry 5646
proteinuria 180
stroke 170
lysosomal storage disease 149
renal disease 149
ventricular hypertrophy 146
renal failure 145
Gaucher disease 141
cardiomyopathy 125
angiokeratoma 111
hypertrophic cardiomyopathy 97
AMD 93
heart failure 69
neuropathy 68
hypohidrosis 68
cornea 68
hypertension 68
Niemann-Pick 58
chronic renal failure 50
amyloidosis 49
genetic disorder 46
Krabbe disease 45
acroparesthesia 45
enzyme deficiency 39
metabolic disorder 37
Tay-Sachs disease 35
metachromatic leukodystrophy 34
MPS I 34
fucosidosis 32
renal insufficiency 31
cold 31
mucopolysaccharidosis 30
glomerulosclerosis 26
diabetes 25
MPS II 25
peripheral neuropathy 25
myocardial infarction 24
Hurler 23
gangliosidosis 23
CCD 22
cancer 22
sarcoidosis 22
anhidrosis 21
vascular disease 21
cystinosis 21
CCD 20
depression 19
ischemia 19
rare disease 18
systemic disease 18
Alport syndrome 18
renal impairment 18
Sandhoff disease 18
glomerulonephritis 18
arteriopathy 17
polycystic kidney 17
heart disease 17
dilated cardiomyopathy 16
MPS VI 16
atherosclerosis 15
leukoencephalopathy 15
myocarditis 15
malnutrition 14
cardiovascular disease 14
microalbuminuria 14
systemic lupus erythematosus 14
IgA nephropathy 14
GM1 gangliosidosis 13
Parkinson's disease 13
nephrotic syndrome 13
dental caries 13
mannosidosis 13
sphingolipidosis 12
Proteinuria 12
congestive heart failure 12
fits 12
sensorineural hearing loss 12
polyneuropathy 12
multiple sclerosis 11
mental retardation 11
mental retardation 11
Fordyce 11
neuronal ceroid lipofuscinosis 11
dementia 11
hemolytic uremic syndrome 11
NPC 11
glycogen storage disease 10
uremia 10
lactic acidosis 10
coronary artery disease 10
atrioventricular block 10
WDM 10
telangiectasia 10
hemochromatosis 10
vasculitis 10
lymphedema 10
GM2 gangliosidosis 9
corneal dystrophy 9
lipidosis 9
leukodystrophy 9
Morquio 9
myocardial ischemia 9
restrictive cardiomyopathy 9
mole 9
chronic pain 9
Danon disease 9
Marfan syndrome 9
Farber 9
cerebral infarction 9
hemangioma 9
Refsum disease 9
cognitive impairment 8
conjunctiva 8
diabetic nephropathy 8
sickle cell disease 8
lipid disorder 8
encephalopathy 8
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 8
membranous nephropathy 8
myopathy 8
hypothyroidism 7
aortic stenosis 7
mitral valve prolapse 7
scrotum 7
homocystinuria 7
lupus 7
HIV 7
mitochondrial disease 7
anemia 7
iron overload 7
transient ischemic attack 7
dysplasia 7
tumor 7
Hypertrophic cardiomyopathy 7
cystic fibrosis 7
ALD 7
CADASIL 7
deafness 7
Ehlers-Danlos syndrome 7
cerebral ischemia 6
chronic renal insufficiency 6
rheumatoid arthritis 6
arthritis 6
keratopathy 6
mole 6
primary hyperoxaluria 6
mitral regurgitation 6
Aspartylglucosaminuria 6
PSS 6
sialidosis 6
Wilson's disease 6
Charcot-Marie-Tooth disease 6
priapism 6
plaque 6
AGA 6
Still 6
SWS 5
abortion 5
ICD 5
gout 5
more...
Symptom
pain 217
abdominal pain 25
diarrhea 25
headache 16
paresthesia 15
weakness 14
dyspnea 14
tinnitus 12
vertigo 11
fatigue 10
anesthesia 10
vomiting 10
arthralgia 10
dizziness 9
angina 9
nausea 9
syncope 8
Gastrointestinal symptoms 8
seizures 7
collapse 7
chest pain 7
thinning 7
regurgitation 6
numbness 5
fever of unknown origin 5
ataxia 5
limb pain 4
rigors 4
hepatosplenomegaly 4
acute pain 4
Neuropathic pain 3
splenomegaly 3
sleepiness 3
exertional dyspnea 3
Wind 3
polyuria 3
livedo 3
myoclonus 3
neurological pain 2
dysarthria 2
blurred vision 2
growing pains 2
anorexia 2
flushing 2
tremor 2
ophthalmoplegia 2
hepatomegaly 2
myalgia 2
erythema 2
discomfort 2
hemiplegia 2
overweight 2
atypical chest pain 2
bloating 2
eds 2
Burning 2
exertional angina 2
cachexia 2
neuralgia 2
constipation 2
cough 2
clubbing 1
general problem 1
chronic cough 1
Psychiatric symptoms 1
discomfort 1
generalized pain 1
starvation 1
Ill 1
neurological disability 1
facial pain 1
fasciculation 1
Skin symptoms 1
memory loss 1
flank pain 1
shortness of breath 1
Mills 1
Physical findings 1
tingling 1
Musculoskeletal symptoms 1
dysesthesia 1
analgesia 1
stigma 1
exertional chest pain 1
pallor 1
Stable angina pectoris 1
nausea and vomiting 1
excessive sweating 1
chest tightness 1
hip pain 1
Unexplained abdominal pain 1
hypercapnia 1
blepharospasm 1
sense loss 1
leg edema 1
bewilderment 1
hypothermia 1
bone pain 1
wheezing 1
dry skin 1
Burning pain 1
Excruciating pain 1
leg pain 1
polydipsia 1
muscle cramps 1
spasticity 1
Gastrointestinal signs and symptoms 1
paraparesis 1
CSR 1
hand pain 1
Drug
Dermatol 63
Cardiovasc 43
ZnO 35
Fabrazyme 30
SiO2 13
Agalsidase alfa 11
TiO2 9
Nephron 8
Nephron 8
Dial 7
Cerezyme 7
Cerezyme 6
Orphan 5
CSF 4
nitroglycerin 4
Migalastat hydrochloride 3
lactose 3
ROC 3
lysine 3
Miglustat 3
SPP 3
SF6 3
Helium 2
TAT 2
Cordarone 2
Cordarone 2
Ceredase 2
NH3 2
vitamin E 2
Asn 2
Myozyme 2
Galactose 2
Amiloride 2
Amiloride 2
Palmitoyl 1
Rosiglitazone 1
DBS 1
Lomotil 1
KGF 1
G418 1
Gelfoam 1
Albumin 1
EPA 1
Senicapoc 1
Urso 1
NADH 1
Bayer 1
Idursulfase 1
Phenytoin 1
Fluorescein 1
ZnCl2 1
Cantor 1
Aldurazyme 1
VCR 1
NYS 1
Vitamin B12 1
Lomotil 1
ZnCl2 1
Ranitidine hydrochloride 1
Aldurazyme 1
ACT 1
Portal 1
Ranitidine 1
Ambroxol hydrochloride 1
CAM 1
Leaf 1
MOF 1
IPD 1
Dilantin 1
Vitamin B 1
Gelatin 1
Fluorescein 1
Gramicidin 1
Angiotensin II 1
BH4 1
Orion 1
Mutagen 1
Enzyme
alpha-galactosidase 708
ACS 52
glucocerebrosidase 24
glucosylceramide synthase 17
alpha-N-acetylgalactosaminidase 16
beta-galactosidase 15
alpha-L-fucosidase 11
hexosaminidase 9
beta-glucosidase 7
peroxidase 7
beta-glucosidase 7
alpha-glucosidase 7
alpha-L-fucosidase 6
alpha-L-fucosidase 6
renin 6
sulfatase 6
ceramide trihexosidase 6
acid phosphatase 5
endonuclease 5
alpha-mannosidase 5
ACE 4
beta-glucuronidase 4
ERK 4
focal adhesion kinase 4
N-acetylgalactosaminidase 4
luciferase 4
aspartylglucosaminidase 4
galactocerebrosidase 4
neuraminidase 4
superoxide dismutase 4
PAM 4
pyruvate dehydrogenase 3
trypsin 3
SOI 3
pyruvate dehydrogenase 3
pyruvate dehydrogenase 3
mannanase 2
21-hydroxylase 2
TAT 2
phosphorylase 2
glucoamylase 2
APC 2
lipase 2
CDH 2
protein kinase 2
urokinase-type plasminogen activator 2
AMPK 2
NPL 2
phosphodiesterase 2
ascorbate oxidase 2
reverse transcriptase 2
lecithin:cholesterol acyltransferase 2
AMPK 2
catalase 2
arylsulfatase A 2
adenine phosphoribosyltransferase 2
glutathione peroxidase 2
NOS 2
P-glycoprotein 2
HK2 2
AMP-activated protein kinase 2
complex I 2
aromatic L-amino acid decarboxylase 1
alpha-amylase 1
thymidine kinase 1
cathepsin B 1
glucose-6-phosphate dehydrogenase 1
glyceraldehyde-3-phosphate dehydrogenase 1
PAT 1
branching enzyme 1
citrate synthase 1
CPT 1
RNA polymerase 1
cathepsin F 1
STR 1
FTR 1
prolidase 1
tryptase 1
phosphoglycerate kinase 1
alpha-L-iduronidase 1
trehalase 1
dipeptidyl peptidase IV 1
malate dehydrogenase 1
proteasome 1
galactose oxidase 1
acyl-CoA dehydrogenase 1
creatine kinase 1
ATPase 1
cathepsin D 1
asparaginase 1
glucose-6-phosphatase 1
prostate-specific antigen 1
caspase-9 1
NO synthase 1
granzyme B 1
glutathione reductase 1
neutral sphingomyelinase 1
methylenetetrahydrofolate reductase 1
dopamine beta-hydroxylase 1
NADPH oxidase 1
CD10 1
CDR 1
phospholipase C 1
glyceraldehyde-3-phosphate dehydrogenase 1
heme oxygenase 1
acyl-CoA dehydrogenase 1
MMP 1
phosphofructokinase 1
sialidase 1
carboxypeptidase Y 1
RNase 1
mitogen-activated protein kinase 1
FPS 1
matrix metalloproteinase 9 1
alkaline phosphatase 1
PAH 1
phosphatidylinositol 3-kinase 1
glyceraldehyde-3-phosphate dehydrogenase 1
chondroitinase 1
iduronate-2-sulfatase 1
glyceraldehyde-3-phosphate dehydrogenase 1
alpha-N-acetylglucosaminidase 1
soluble epoxide hydrolase 1
PCE 1
galactokinase 1
hypoxanthine-guanine phosphoribosyltransferase 1
transcriptase 1
enolase 1
sialyltransferase 1
PMT 1
glyceraldehyde-3-phosphate dehydrogenase 1
paraoxonase 1
methylenetetrahydrofolate reductase 1
alcohol dehydrogenase 1
CD13 1
sialyltransferase 1
15-lipoxygenase 1
MDR 1
NADPH oxidase 1
lactate dehydrogenase 1
arabinosidase 1
sialyltransferase 1
Compound
Dec 409
Clin 224
Gb3 224
silicon 222
GAL 200
water 106
DNA 89
silver 65
galactose 60
Cardiol 58
Letter 57
creatinine 56
ACS 52
ACS 52
oxygen 45
nitrogen 40
hydrogen 35
aluminum 34
phosphate 29
His 28
GM1 26
ethanol 25
copper 22
COS 21
iodine 19
methanol 18
glucose 17
sodium 17
boron 17
titanium 15
urea 15
arginine 14
GM2 13
germanium 13
iron 13
SiO2 13
glucose-6-phosphate 12
zinc 11
CO2 11
calcium 11
nitric oxide 11
Cer 10
acetone 10
potassium 9
rubidium 9
tungsten 9
chloroform 9
mercury 8
Dial 8
threonine 8
salt 8
isopropanol 8
methane 8
glutamine 8
tin 8
Asp 7
DNFB 7
GalNAc 7
HCl 7
sulfate 6
PEG 6
homocysteine 6
tyrosine 6
Optimal 6
MgO 6
phosphorus 6
cadmium 6
molybdenum 6
TEM 6
formaldehyde 6
glycerol 5
TOF 5
formaldehyde 5
toluene 5
Amiodarone 5
ammonia 5
acetate 5
NH2 5
palmitic acid 5
barium 5
TNF 5
Phe 4
PAM 4
PAM 4
methionine 4
DDD 4
aspartic acid 4
H2S 4
acrylic acid 4
selenium 4
ammonium 4
GM3 4
H2S 4
cysteine 4
PAM 4
octyl 3
2-propanol 3
Isoproterenol 3
tryptophan 3
tryptophan 3
octyl 3
lysine 3
nitrate 3
Chloroquine 3
piperidine 3
aspartic acid 3
Neuronal 3
PEG 3
PAA 3
aspartic acid 3
alanine 3
serine 3
benzene 3
hexane 3
tryptophan 3
Carbon 3
Chloroquine 3
Angiotensin II 3
GlcNAc 3
chromium 3
acetonitrile 3
leucine 3
octyl 3
Lead 3
DEAE 3
SOA 3
CDH 3
piperidine 3
aspartic acid 3
tryptophan 3
2-propanol 3
cAMP 3
EDTA 2
Collagen 2
CAM 2
NKT 2
EDTA 2
C2H2 2
aldosterone 2
formic acid 2
pyrrolidine 2
formic acid 2
PAS 2
N-isopropylacrylamide 2
BNP 2
Gb4 2
GSH 2
LSD 2
NBS 2
CAT 2
formic acid 2
PMA 2
nickel 2
formic acid 2
proline 2
hydroxide 2
formic acid 2
formic acid 2
GSH 2
formic acid 2
more...