Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For effective treatment of coronary heart disease with calcium antagonists, knowledge of both the dose-response relationship of a remedy and equipotent dosage for comparison of different drugs is necessary. We performed controlled studies to evaluate the influence of single oral doses of calcium antagonists on ischemic ST-depression (calculated as the mean of all exercise and recovery minutes = mean ST-depression) in exercise ECGs of patients with proven CHD and stable angina pectoris. Ergometries were carried out under constant conditions, particularly with individually constant work load and duration. All calcium antagonists reduced ischemic ST-depression during ergometry dose-dependent when compared to placebo. Diltiazem: 90 mg: 6% (n.s.), 120 mg: 19% (n.s.) und 180 mg: 26% (p less than 0.025); gallopamil: 25 mg: 19% (n.s.), 50 mg: 34% (p less than 0.01) und 100 mg: 57% (p less than 0.0025); nifedipine-Cps.: 5 mg: 17%, 10 mg: 33% und 20 mg: 42%; nifedipine-Tbl.: 20 mg: 8% (p less than 0.05), 40 mg: 23% (p less than 0.057 und 60 mg: 31% (p less than 0.05); tiapamil: 300 mg: 30% (p less than 0.05) und 600 mg: 60% (p less than 0.01). As the result of our findings, comparable antiischemic effects can be expected with 120 mg diltiazem, 50 mg gallopamil, 20 mg nifedipin as capsule or 60 mg nifedipin as tablet and 600 mg tiapamil.
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PMID:[Dose-response relation of gallopamil in comparison with nifedipine, diltiazem and tiapamil in patients with coronary heart disease]. 269 66

Serial blood measurements of myoglobin (MG) revealed a common trend of change in acute macro- and microfocal myocardial infarction, focal myocardial dystrophy, angina of effort and angina at rest as well as unstable angina. Differences in myoglobinemic parameters (MG peak level, increment rate, normalization time) between different clinical variants of CHD are quantitative. It is suggested that there is an intravital relationship between each of the examined clinical variants, in their acute phase, and a specific equivalent of an acute myocardial ischemic damage focus, as shown by the degree of hypermyoglobinemia.
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PMID:[Hypermyoglobinemia in ischemic heart disease]. 272 65

From 1986-1988, 43 CHD patients were analyzed on the relationship between the patterns of syndrome differentiation and the features of coronary and left ventricular angiocardiography. There were 17/18 cases (94.41%) with fixed stenotic lesions of coronary arteries in the pattern of blood stasis; 1/18 cases (5.5%) had coronary spasm; none was normal. The cases with blood stasis pattern were mostly of old myocardial infarction, effort angina and effort coexisting with spontaneous angina. They complained a fixed squeezing substernal pain provoked by physical exertion. In 14/25 cases (56%) of syndrome differentiation with Qi deficiency and Qi stagnation, the coronary arteries were normal. 3/25 cases (12%) had coronary arterial spasm and 8/25 cases (32%) had stenotic lesions in coronary artery. The cases of Qi deficiency and Qi stagnation were mostly of spontaneous and atypical angina. They complained precordial distress or pain with undefinite location associated with shortness of breath and fatigue. The distress was relieved by a deep breath. Abnormal ejection fraction was seen mostly in the pattern of Qi symptoms and signs but less in the pattern of blood stasis (P less than 0.002). There was no significant difference in platelet aggregation test and echocardiogram between the two patterns.
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PMID:[Relation of the patterns of syndrome differentiation and features of coronary and left ventricular angiocardiography in coronary heart disease]. 273 90

After finding that Fomitiporia Runctata Murr had been used to treat angina pectoris as a folk remedy, medical workers of Fujian Sanming Fongous Institute engaged in the separation and identification of flora, and made out sugar-coated tablets of GML. This article reports clinical observation of tablets of GML treating 270 cases of CHD. Among the control group, 31 cases were treated by Persantine, 20 cases by Huo Xin Dan, 30 cases by compound Salviae miltiorrhizae. Among 222 cases of angina pectoris, 80 cases acquired evident effect (36%), 98 cases acquired improvement (44%), 42 cases failed to respond to the treatment (19%) and 2 cases became worse (1%). Total effective cases were 178 and total effective rate was 80%. There were 250 cases who had ECG evaluation: 37 cases acquired evident effect (15%), 95 cases showed improvement (38%), 116 cases had no change (46%) and 2 cases became worse (1%). Total effective cases were 132 and total effective rate was 53%. There was no significant difference between the effect of tablets of GML and that of Persantine, Huo Xin Dan and compound Salviae miltiorrhizae. According to the clinical laboratory observation, there were many functions of GML, such as antimyocardial ischemia, regulating heart rate, antiectopic cardiac rhythm and improving cardiac function and disorder in hemorrheology. The authors also used GML to treat 90 cases of arrhythmia.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A clinical study of guan mai Le in the treatment of coronary heart disease]. 276 25

Raised function of platelets with an increase in their aggregation activity in vitro and an increase in spontaneous intravascular activation as well as imbalance of the prostacyclin-thromboxane system with a shift to the predominance of proaggregation agents were detected in CHD patients after myocardial infarction suffering from stable angina. An inhibiting effect of beta-adrenergic receptor blocking agents and acetylsalicylic acid on the synthesis of thromboxane A2 was observed. No marked effect of dipyridamole on the prostacyclin-thromboxane system was noted.
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PMID:[Effect of the complex treatment of stable stenocardia on the status of the prostacyclin-thromboxane system]. 287 21

A total of 96 males aged 80 to 92 (98% of the persons of this age and sex residing in October 1, 1983, in one of the administrative districts in Leningrad) were examined at home by standardized methods. Arterial pressure (AP) was measured and ECG at rest was recorded; 73 persons living an active life were interviewed using a WHO questionnaire with regard to angina pectoris of effort. The blood lipid composition was studied in 54 persons. Systolic arterial hypertension (AP greater than or equal to 160 mm) was found in 65.6%, AP greater than or equal to 190 mm in 21.9%, isolated diastolic arterial hypertension was not detected, together with systolic hypertension it was observed in 10.4%. The blood lipid composition in males over 80 was characterized by rather low total cholesterol and triglyceride levels and quite a low atherogeneity rate (3.3 +/- 0.26 U). Epidemiological CHD diagnosis was established in 45.7% of the persons examined including myocardial infarction in the anamnesis in 16.7%. The results obtained indicate to more frequent associations of CHD with a high AP and tendencies to an atherogenic shift of the blood lipid fractions.
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PMID:[Ischemic heart disease, arterial pressure and the lipid composition of the blood in men over 80 in Leningrad (epidemiological survey data)]. 293 48

A total of 2096 males born in 1916-1935, residing by 1976 in the Petrogradsky District of Leningrad, were twice examined (with an interval of 7.6 yrs) using epidemiological methods. This group was equal to 53.6% of the persons subjected to the first screening. Data on the dead and those who had not come to the second screening, were not analyzed. The total frequency of nonfatal CHD from 1976 up to 1984 raised from 12.6 to 19.2%. As was shown by the assessment of a WHO questionnaire with relation to angina of effort and an analysis of ECG at rest, CHD was undetectable during the second screening in some of the examinees with CHD detected during the first screening. Further on the angina syndrome was not reaffirmed in 52.3% of the patients with previously diagnosed angina, "ischemic" ECG changes were not recorded in 37.1% of the persons with previously detected ischemic codes. Positive ECG time course was noted in 52.1% of the persons with ECG changes typical of CHD detected during the first screening. In spite of a marked tendency to an increase in the total CHD frequency a long-term observation demonstrated a possibility of a favorable time course of chronic CHD and remission in this disease.
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PMID:[Characteristics of the course of non-fatal ischemic heart disease (data of a prospective study of the open population of men over 40]. 296 44

Combinations of antianginal drugs may be used for an additive effect against angina, but also to off-set unwanted effects of one drug with another, either by direct effects or by a reduction of dosage of each drug. Based on earlier studies with separate drugs we have now examined the effect of 150 mg bupranolol combined with 40 mg isosorbide dinitrate (ISDN) in one retarded tablet, given twice daily. 22 patients with CHD entered the study, 11 of those with and 11 without signs of ischemia during exercise. In an acute radionuclide ventriculographic (RNV) study 2 h after the tablet, ejection fraction (EF) during exercise increased only in patients with exercise ischemia (+6%, p less than 0.001). In the other patients EF did not change. After 21 days of treatment echocardiographically determined end-systolic and end-diastolic diameters decreased, resulting in an increase of shortening fraction by 15.6% (p less than 0.05). Heart rate, systolic and diastolic pressure and ST-segment depression decreased significantly. In another acute RNV study the effect of a venous vasodilator, molsidomine 4 mg s.l., was examined after nifedipine 10 mg s.l. in 19 patients with CHD, 9 with and 10 without exercise ischemia. Differences between drugs were most prominent during exercise. In the nonischemic group EF rose by 6.6% after nifedipine (n.s.) and by 14% after molsidomine (p less than 0.01 against control). In the group with ischemia EF rose by 12.6% after nifedipine and by 17.4% after additional molsidomine, significant against control (p less than 0.01) as well as against nifedipine (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Interactions of vasodilators with calcium entry- and beta-blockers in patients with coronary heart disease. 302 1

The use of various doses of metoprolol (spesicor, Leiras, Finland), a selective beta 1-adrenoblocker, in patients with CHD combined with clinical or instrumentally detectable symptoms of bronchial asthma or stage I-II essential hypertension with angina pectoris of I-II functional classes, has shown that metoprolol cardioselective blockade is a relative phenomenon which has definite correlation with a dose, duration of therapy, and the initial status of the bronchopulmonary system. An antianginal effect was observed in 68.5% of patients, an antihypertensive effect--in 71.3%, side-effects--in 6.4%.
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PMID:[Possibilities and limitations of selective beta 1 adrenergic receptor blockade in clinical practice]. 306 9

A study was made of 41 CHD patients with complete occlusion of one of the major coronary arteries, 32 of them (78%) had a previous history of myocardial infarction (MI). A clinical course in the group of patients after MI was characterized by less severe angina, lesser daily requirement in nitroglycerin, and higher physical exercise tolerance. A more stable course of angina after MI in occlusion of one of the coronary arteries was determined by the level of occlusion, the state of the myocardial zone below the site of occlusion, a possibility of its ischemic response, and the type of collateral circulation.
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PMID:[Clinical manifestations of ischemic heart disease in complete occlusion of one of the major coronary arteries]. 321 36


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