Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six patients (2 males and 4 females, mean age of 46 years) with X syndrome were reported in this paper. All patients presented with typical exertional angina pectoris. In 4 patients the angina had a variable threshold of onset, it often occurred at rest and occasionally nocturnally. The electrocardiogram during chest pain showed ST segment depression of more than 0.05-0.1 mV in all 6 patients. The treadmill or bicycle ergometer exercise test was positive in 4 cases (ST segment depression > 0.1 mV), equivocal in 1 (ST segment < 0.1 mV) in whom the 201Tl exercise myocardial perfusion scan showed sign of ischemia, and negative in 1 in whom atrial pacing at heart rate of 135 beats/min induced angina and ST segment depression of 0.1-0.15 mV. Echocardiograms and X ray chest films revealed no sign of ventricular hypertrophy or enlargement. The 201Tl exercise myocardial perfusion scan was performed in 5 patients, which showed signs of ischemia in 4 patients and suspected to have ischemia in 1. Left ventriculograms and coronary angiograms were normal in all 6 patients. Ergonovine provoking test (total dose of 0.4 mg) was negative in 5 patients, it was not performed in 1 in whom there was no evidence of coronary artery spasm by angiogram during appearance of electrocardiographic ischemic changes and chest pain. Left ventricular endomyocardial biopsy was performed in 1 patient, which showed significant smooth muscle cell proliferation in the medial layer of a small artery with diameter of 62.5 mu which produced narrowing of the lumen.(ABSTRACT TRUNCATED AT 250 WORDS)
Zhonghua Xin Xue Guan Bing Za Zhi 1992 Oct
PMID:[X syndrome--report of six cases]. 130 21

Thirteen patients with totally silent myocardial ischemia (group 1) and 15 patients with effort angina (group 2) were studied. The coronary angiography of both groups indicated coronary artery stenosis > or = 50%. In group 1, the beta-endorphin plasma level (beta-EPL) during rest was significantly higher than those in group 2 (15.639 +/- 1.258 pg/ml and 8.920 +/- 1.478 pg/ml, respectively, P < 0.01). There were significant increases in beta-EPL in both groups after exercise as compared with that before exercise (beta-EPL is 33.801 +/- 6.243 pg ml/in group 1, P < 0.01; 18.169 +/- 3.540 pg/ml in group 2, P < 0.01). The difference between two groups after exercise was also significant (P < 0.05). The plasma level of noradrenaline (NE) during rest was 0.267 +/- 0.035 ng/ml, adrenaline (E) was 0.112 +/- 0.018 ng/ml in group 1, and NE was 0.218 +/- 0.032 ng/ml and E was 0.110 +/- 0.015 ng/ml in group 2. After exercise, NE was 1.017 +/- 0.160 ng/ml (P < 0.001), E 0.276 +/- 0.076 ng/ml (P < 0.001), E 0.260 +/- 0.043 ng/ml (P < 0.01) in group 2. There was no difference between two groups both in rest and after exercise (P > 0.05). This study indicates that the high plasma beta-endorphin level might play a major role in the occurrence of totally silent myocardial ischemia.
Zhonghua Xin Xue Guan Bing Za Zhi 1992 Apr
PMID:[Assessment of plasma catecholamine and beta-endorphin contents in patients with silent myocardial ischemia and angina pectoris]. 147 88

Seventeen patients with positive maximal or submaximal bicycle-exercise test accompanied by painlessness and 14 patients with susceptible coronary heart disease with negative exercise test were studied and traced for 36 months. The patients underwent repeated bicycle-exercise test of the same stress and compared with those before 36 months. The results showed that 7/17 patients (41.2%) had an increase in the depressed level of ischemic type ST segment induced by exercise test. 3 of them developed effort angina pectoris: 1 suffered from myocardial infarction, 1 had recurrent atrial flutter and left heart failure, and 1 suddenly died from cardiac disease. The cardiac event rate was 3/17 (17.6%) in this group. While 14 patients with negative exercise test had no cardiac events. It seems to mean that silent myocardial ischemia detected by exercise test might have potential danger of cardiac events.
Zhonghua Xin Xue Guan Bing Za Zhi 1992 Apr
PMID:[Clinical outcome of silent myocardial ischemia detected by bicycle ergometry study]. 147 90

Twenty patients with angina pectoris were treated with external counterpulsation (ECP) for 36 hours, and the effects of the therapy were evaluated by comparing the images of thallium-201 myocardial perfusion before and after ECP. Improvement of myocardial perfusion after ECP, evidenced by decrease in area of defects in scintigram, was demonstrated in 15 (75%) cases. The mechanism of the effect of ECP on ischemic myocardium was discussed.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Aug
PMID:[External counterpulsation in treating angina pectoris evaluated by Tl-201 myocardial perfusion imaging]. 181 90

Plasma beta-endorphin (beta-END) levels were measured before, after exercise tests and at the onset of spontaneous angina in 23 anginal patients (group 1), 23 patients with silent myocardial ischemia (group 2) and 15 healthy volunteers (group 3). The pain perception in three groups was also measured. Before and after exercise, the concentration of beta-END in group 1 was significantly lower than that in group 2 and group 3. The concentration of beta-END during onset of spontaneous angina was also lower than that of angina-free period in group 1. There was no significant difference of beta-END between group 2 and 3. The values of the pain threshold and tolerance in group 1 were lower than those of group 2 and 3. These data suggested that plasma levels of beta-END may be related to occurrence of angina. The anginal patients had a hypersensitivity and hypotolerance for pain. A positive correlation was found between plasma beta-END and pain threshold, the levels of beta-END might affect the pain perception during the onset of myocardial ischemia.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Feb
PMID:[The role of beta-endorphin and pain perception in silent myocardial ischemia]. 206 Apr 63

The reliability of serum MM3/MM1 ratio as a marker for AMI was evaluated in 81 consecutive coronary-care admission. Of these, 62 patients were diagnosed as definite infarction and 19 patients as angina, using WHO criteria. The MM3/MM1 ratio in the admission serum sample was 1.85 +/- 2.01 in 62 patients with definite infarction; in contrast, the MM3/MM1 ratio was 0.24 +/- 0.14 in 19 patients with angina (P less than 0.01 for MI group vs angina group). Among the AMI patients admitted within 12 h after onset, the diagnostic accuracy of the ratio MM3/MM1 was higher than CK, CK-MB, LDH, LD1/LD2 and GOT and similar to Mb in the initial serum samples. It seems that the MM3/MM1 ratio was a better enzyme marker than the others in the early stage of AMI, especially before 12 h.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Dec
PMID:[Serum isoforms of creatine kinase MM (MM3/MM1 ratio) in the diagnosis of acute myocardial infarction]. 209 52

Fifty cases of clinically proven or suspected coronary artery disease (CAD) underwent dipyridamole-technetium-99m CPI (DP-99mTc. CPI) myocardial tomography imaging and coronary angiography. All cases with angiographically proven CAD had positive DP-99 mTc. CPI. The sensitivity was 100%. Six of 13 cases with normal coronary arteriogram showed false positive results (3 cases of hypertrophic cardiomyopathy and 3 cases of chest pain with unknown causes). Therefore, the specificity was 53.8% (7/13). The positive predictive accuracy of DP-99m Tc. CPI myocardial imaging was 88.0%. However, We do not consider it justified to apply this statistics to general population as our patients were highly selected. One hundred and twelve myocardial segments of left ventricle were shown to be infarcted or ischemic by either radionuclear imaging or ECG. In 108 segments with abnormal images, only 10 in patients with hypertrophic cardiomyopathy had normal coronary artery supply. Therefore, the reliability of DP-99 mTc. CPI myocardial imaging to display infarcted or ischemic segments was 91.0% (102/112). The ability for 99mTc. CPI imaging to differentiate between infarcted and ischemic lesions was somewhat indefinite, especially in case of localized infarction. The reason of this shortcoming was discussed. Ninety segments were shown to be infarcted or ischemic by ECG, 4 of which had no corresponding coronary artery stenosis. However, in 12 of the 22 segments with normal ECG pattern the corresponding coronary arteries were either occluded or stenosed, resulting in 54.5% (12/22) false negativity. Most of these false negatives were found in posterior and septal walls. Angina pectoris after dipyridamole infusion occurred in 4 of our 50 patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Dec
PMID:[The value of dipyridamole-technetium-99m carbomethoxyisopropylisonitrile (CPI) myocardial tomography imaging in diagnosing coronary artery disease]. 209 54

The levels of total cholesterol, triglyceride, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B in the serum were measured in a selected series of 100 CAD patients (77 men and 23 women) who underwent coronary angiography and 141 non-CAD controls. Mean values of those variables differed significantly between the CAD and non-CAD groups matched in age, body weight, hypertension and smoking. There are significant difference in apolipoproteins A1, B and the ratio of apolipoprotein B to A1 between angina and myocardial infarction groups. Using stratified and multivariate stepwise regression analysis, it was shown that the apo A1, apoB/apoA1 are more sensitive and specific than the ordinary indices (e.g. total cholesterol, triglycerides, LDL-C and HDL-C) in estimating the degree of coronary artery stenosis and the differentiation of CAD from other diseases.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Aug
PMID:[Serum apolipoprotein AI, B levels in patients with coronary diseases]. 212 69

After finding that Fomitiporia Runctata Murr had been used to treat angina pectoris as a folk remedy, medical workers of Fujian Sanming Fongous Institute engaged in the separation and identification of flora, and made out sugar-coated tablets of GML. This article reports clinical observation of tablets of GML treating 270 cases of CHD. Among the control group, 31 cases were treated by Persantine, 20 cases by Huo Xin Dan, 30 cases by compound Salviae miltiorrhizae. Among 222 cases of angina pectoris, 80 cases acquired evident effect (36%), 98 cases acquired improvement (44%), 42 cases failed to respond to the treatment (19%) and 2 cases became worse (1%). Total effective cases were 178 and total effective rate was 80%. There were 250 cases who had ECG evaluation: 37 cases acquired evident effect (15%), 95 cases showed improvement (38%), 116 cases had no change (46%) and 2 cases became worse (1%). Total effective cases were 132 and total effective rate was 53%. There was no significant difference between the effect of tablets of GML and that of Persantine, Huo Xin Dan and compound Salviae miltiorrhizae. According to the clinical laboratory observation, there were many functions of GML, such as antimyocardial ischemia, regulating heart rate, antiectopic cardiac rhythm and improving cardiac function and disorder in hemorrheology. The authors also used GML to treat 90 cases of arrhythmia.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A clinical study of guan mai Le in the treatment of coronary heart disease]. 276 25

Ten cases of aortic regurgitation in the patients with aortoarteritis in our group were studied during the period 1958-1988. Nine out of 10 patients with aortoarteritis were performed by aortography. The incidence of aortic regurgitation is 2.2 per cent in 450 patients with aortoarteritis. In all the patients with aortic regurgitation diastolic murmurs were heard in the aortic valves. X-ray findings showed dilatation of ascending aorta with aortic regurgitation in 10 patients and enlargement of left ventricle in 7 patients. Subclavian artery and carotid artery were involved in all patients. Descending aorta or abdominal aorta were also involved in 6 of them. Two patients with angina pectoris were studied by coronary arteriography and the coronary arteries were normal. Clinically, these cases should be differentiated from aortic regurgitation of other etiology.
Zhonghua Xin Xue Guan Bing Za Zhi 1989 Feb
PMID:[Aortoarteritis complicated by aortic insufficiency (with an analysis of 10 cases)]. 276 38


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