Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of fluvastatin and fenofibrate on O2-generation by neutrophils and MDA concentration in mixed hyperlipidaemic patients with stable angina was studied. Thirty-five patients (13 men and 22 women aged 40-77 years) were randomly divided into two groups. Group I comprised 20 patients who were administered fluvastatin 40 mg once daily at bedtime for 30 days. Group II consisted of 15 patients who were administered fenofibrate 200 mg once daily at bedtime for 30 days. The control group comprised 11 clinically healthy persons, aged 21-54 years. Neutrophil O2-generation was measured using Bellavite et al. method and MDA concentrations in plasma and erythrocytes were determined by Placer et al. method. It was shown that fluvastatin had no significant effect on O2-generation while fenofibrate increased its generation. None of the examined drugs caused changes of MDA concentrations in plasma and erythrocytes.
Pol Merkur Lekarski 2003 Apr
PMID:[Effect of fluvastatin and fenofibrate on reactive oxygen species generation and lipid peroxidation in patients with dyslipidemia]. 1286 84

The effect of fluvastatin and fenofibrate on antioxidative enzymatic activity in patients with stable angina and mixed hyperlipidaemia was investigated. Thirty-five patients (13 men and 22 women) aged 40-77 years, were randomly divided into two groups. The first group comprised 20 patients who were administered fluvastatin 40 mg once daily at bedtime for 30 days. The second group consisted of 15 patients who were administered fenofibrate 200 mg once daily at bedtime for 30 days. The control group comprised 11 clinically healthy persons aged 21-54 years. The activities of SOD-1, CAT and GSH-Px in erythrocytes were measured. Fluvastatin induced an increase of the activities of all investigated enzymes. Fenofibrate caused no change of enzyme activities in patients with dyslipidaemia.
Pol Merkur Lekarski 2003 Apr
PMID:[Effect of fluvastatin and fenofibrate on the antioxidative barrier enzyme activity in patients with dyslipidemia]. 1286 85

We present a case of a 71-year-old male with exercise angina and two-vessel coronary artery disease (CAD). As the first step of treatment, the patient underwent successful coronary angioplasty with a stent implantation in the circumflex artery and remained free from angina for the following month. After this period, the patient underwent elective angioplasty of left anterior descending (LAD) coronary artery which was complicated by dissection, requiring implantation of two stents. Because of recurrent angina the patient underwent three months later another coronary angiography which revealed in-stent restenosis in LAD. The patient underwent repeated angioplasty with a good angiographic results, however, without cessation of angina Clinical and angiographic indications for percutaneous coronary interventions, according to the recent ACC/AHA guidelines, are discussed.
Kardiol Pol 2003 Jan
PMID:[Repeated coronary angioplasty due to restenosis and disease progression - a case report]. 1450 2

Following an abbreviated historical review of literature related to angina pectoris spanning the period from olden days to the beginning of the XIX th century, this paper analyses Jan Cenner's doctoral dissertation entitled "Dissertation inauguralis medica de angor pectoris", written in Cracow, Poland in 1820. A conciliation of the information regarding coronary artery disease with the current state of medical understanding is made in a tabular form and an attempt at an assessment of treatment rules (including prevention, general non-specific therapy, local treatment, dietary management and the use of pharmacological agents) according to updated medical criteria follows. The authors' goal is an objective evaluation of the real scientific value of Cenner's work in light of nearly two centuries of progress in medical knowledge. Emphasis is placed on those diagnostic findings and therapeutic paths relating to coronary artery disease that are currently used in medical practice.
Kardiol Pol 2003 Apr
PMID:[Coronary disease in the past. An attempt at evaluating the dissertation by Jan Cenner "De angor pectoris" (1820) in the context of contemporary knowledge]. 1451 60

A case of a 70-year-old female with hypertension, atrial fibrillation and angina pectoris, admitted to the hospital due to echocardiographically detected left atrial tumour, is presented. Differential diagnosis included thrombus, myxoma, infectious or neoplastic tumour. The patients underwent surgery. Histopathological examination revealed the presence of an abscess in the left atrium. This report underlines the difficulties in the diagnosis of cardiac tumours.
Kardiol Pol 2003 Sep
PMID:[Abscess of the mitral annulus mimicking left atrial tumour - case report]. 1461 1

A 43-year-old men with hemophilia A was admitted to CCU due to anginal pain lasting for sixteen hours. ECG revealed anterior wall myocardial infarction and elevated CK and MB-CK levels confirmed the diagnosis. Exercise test performed later was positive and the patient underwent elective coronary angiography which showed 90% stenosis of left anterior descending (LAD) and closed circumflex coronary artery. Next, angioplasty of LAD, preceded by antihemophilic globulin (factor VIII) administration, was successfully performed.
Kardiol Pol 2003 Nov
PMID:[Myocardial infarction in a patient with hemophilia A--a case report]. 1466 93

The aim of the study was to assess the effect of transmyocardial laser revascularization (TMLR) alone and in combination with coronary artery bypass grafting (CABG) on the angina score (CCS--Canadian Cardiovascular Society class), exercise tolerance and left ventricular function 6 months after the procedures. Sixty two patients were subjected to revascularization, 38 to sole TMLR procedure and 24 to combination CABG and TMLR (CABG/TMLR group). The angina score and exercise stress test together with radionuclide ventriculography were performed before and 6 months after the operation. The angina class and exercise tolerance were similar in both groups preoperatively. After the operation the improvement was seen in both groups with no statistical difference. The left ventricular ejection fraction were 61 +/- 8% and 54 +/- 8% (p < 0.05) before operation and after 6 months respectively. Transmyocardial laser revascularisation alone and in combination with coronary artery bypass grafting may relieve the angina and improve the exercise tolerance. However the left ventricular ejection fraction may drop significantly.
Pol Merkur Lekarski 2003 Dec
PMID:[Clinical outcome of patients after transmyocardial laser revascularization alone and combined with coronary artery bypass grafting]. 1505 55

We present a case of a 49-year-old male with myocardial infarction in a course of variant angina. He was treated successfully with streptokinase, calcium antagonist and nitrates. Coronary angiography showed spasm of the left coronary artery, proximal spasm of the right coronary artery and myocardial bridging of the left anterior descending artery. He has been stable and symptom-free on a treatment with long acting calcium antagonist, nitrates and statin for 3-years.
Kardiol Pol 2004 Aug
PMID:[Myocardial infarction in patient with variant angina]. 1545 81

Takayasu arteritis is a rare, inflammatory disease affecting mainly young women and is more prevalent in Asia and Latin America. Its etiology is obscure. It involves the aorta and its main branches. The typical lesions are represented by obliteration and aneurysmatic dilatation of arteries and ostial stenosis. We report a case of a 51-year-old woman with Takayasu arteritis and coronary disease, complaining of angina pectoris CCS class IV. The patient underwent successful angioplasty of LAD. During 6-month follow-up she remained asymptomatic. Various therapeutic options of revascularization are reviewed.
Kardiol Pol 2004 Sep
PMID:[Successful angioplasty of the left anterior descending artery in a woman with Takayasu arteritis and associated coronary disease]. 1553 38

Hepatocyte growth factor (HGF) takes part in tissue regeneration after injury. It is a potent survival and regeneration factor after severe tissue damage. It promotes cell growth and protection from apoptosis, regulates the cell migration and differentiation. HGF is a subject of intensive investigations in order to apply it in the future in gene therapy to improve treatment of angina pectoris or intermittent claudication. The aim of this review is discussion about the role of HGF in pathogenesis and treatment of atherosclerosis. Angiogenetic activity of HGF was proven in vivo as well as in vitro. In patients with collaterals increased HGF plasma concentration was revealed. It is possible to determine with high probability the risk of cardiovascular event on the basis of HGF concentration. Plasma concentration of this factor increases dramatically after heparin injection, particularly after unfractionated heparin. Also other drugs (ACE-inhibitors) may take part in regulation of HGF synthesis.
Pol Merkur Lekarski 2004 Jul
PMID:[Hepatocyte growth factor (HGF) and atherosclerosis]. 1555 22


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>