Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lymphocyte beta-adrenergic receptor density and plasma catecholamine concentrations were determined in 28 patients with acute myocardial infarction and compared with those in patients with angina pectoris and healthy persons. In patients with acute myocardial infarction beta-adrenergic receptor density was significantly lower (p less than 0.001) and plasma catecholamine levels significantly higher (p less than 0.001) as compared with corresponding values in patients with angina pectoris or healthy persons. beta-adrenergic receptor density in patients with angina pectoris were not significantly different from those in controls. A significant negative correlation between beta-adrenergic receptor density and plasma norepinephrine levels was observed in patients with acute myocardial infarction (r = -0.593; p less than 0.001; r = -0.615; p less than 0.001 respectively). It is suggested that decreased beta-adrenergic receptor density is a consequence of elevated plasma catecholamine levels in patients with acute myocardial infarction. It has been well documented that acute myocardial infarction is associated with enhanced activity of the sympathetic nervous system. Several studies have already been done showing that urinary excretion of catecholamines and plasma catecholamine concentrations are raised in the acute phase of myocardial infarction. Particularly high levels of plasma catecholamines appeared to be related to the severity of clinical course of myocardial infarction and were found in patients with cardiogenic shock, heart failure and arrhythmias. It is of interest that the peak elevation of plasma catecholamines correlated with the extent of myocardial damage as reflected by peak plasma CK activity and also correlated with acute and long-term mortality.(ABSTRACT TRUNCATED AT 250 WORDS)
Mater Med Pol
PMID:Beta-adrenergic receptors and catecholamines in acute myocardial infarction. 256 61

An attempt of mechanical restoration of coronary artery patency and its angioplasty was carried out in 37 patients including 9 with acute myocardial infarction within 5 hours after the onset of an angina pain. The procedure was effective in 17 patients (45.9%), including 6 with acute myocardial infarction (66.7%). Mean time of a coronary artery occlusion was 5.1 weeks in the group with a good result in comparison with 17.2 weeks in the group with the unsuccessful procedure. In patients in whom restoration of a coronary artery patency was carried out within up to 3 months after its occlusion the procedure was effective in 64 per cent of them. Effectiveness of restoration of a coronary artery patency and its dilatation depends on the time from its occlusion to the procedure. The early attempt of the restoration of a coronary artery patency is effective in the majority of patients. In cases of the unsuccessful recanalization of a coronary artery occluded for a short time the main limitation of the procedure effectiveness was the vessel anatomy. The follow-up of 17 patients after a successful procedure showed restenosis or reocclussion in 6 of them (35%). It was referred in 1 case to the patient in whom restoration of a vessel patency was carried out during acute myocardial infarction (17%), and in 5 others to patients with a chronic occlusion of a coronary artery (45.5%).
Kardiol Pol 1989
PMID:[Angioplasty in acute and chronic occlusion of the coronary arteries]. 262 8

128 consecutive patients with a first myocardial infarction, admitted within 4 hours after the onset of an angina pain, were divided into two groups according to the history of the peptic ulcer. Group I (with a negative history, n = 72) received intravenously 1,000,000 units of streptokinase followed by intravenous heparin infusion for 5-7 days. Group II (with a positive history, n = 56) was the control one. In hospital mortality was 2.8% in group I and 5.3% in group II (N. S.). Coronarography performed during second or third week of hospitalization revealed the patency of a coronary artery supplying an infarcted region twice as frequent in group I than in group II (78% vs 41%, p less than 0.001). Percentage of patients with the early serum peak of CKMB activity (from 8 to 12 hours from the start of therapy) suggesting early recanalization of a coronary artery supplying an infarcted region was significantly higher in group I (44.7% and 70.1%) than in group II (7.8% and 19.5%). Both differences between groups were significant (p less than 0.001). Early serum peak of CKMB activity (from 8 to 12 hours from start of treatment) was stated respectively in 46.5% and 81.4% of patients of group I in which subsequent coronarography revealed the patency of a coronary artery supplying the infarcted region.
Kardiol Pol 1989
PMID:[Intravenous streptokinase treatment of acute myocardial infarction. I. Effect of the treatment on the course of infarction and the patency of the artery supplying the infarction area]. 262 9

The paper presented results of early exercise tests performed after myocardial infarction in 102 patients. Examinations were performed on the average, 22 days after the onset of myocardial infarction symptoms. In 52 patients a positive results of the exercise test was stated: lowering of ST-T segment (n = 25), ventricular arrhythmias (n = 16), ST-T segment elevation (n = 15), angina pain (n = 5), and a fall of systolic arterial pressure (n = 4). Two of above mentioned symptoms were observed in some patients. Exercise test was limited by a pulse rate (70% of predictive, maximal pulse rate and) or the work load (up to 125 Watts). No significant complications were observed.
Kardiol Pol 1989
PMID:[Early exercise test after myocardial infarction. Our experience-- results of the examinations of 102 patients]. 262 11

An effect of the electrocardiographic exercise on serum 6-keto-PGF1 alpha was investigated in healthy individuals and patients with exercise-induced stable angina pectoris. It was found that serum 6-keto-PGF1 alpha concentration was higher in healthy individuals following single exercise and at rest than that in the patients with exercise-induced stable angina pectoris. Single exercise increased serum 6-keto-PGF1 alpha concentration only in healthy individuals.
Pol Tyg Lek 1989 Jun 05
PMID:[Effect of a single episode of exertion on serum 6-keto-PGF1 alpha concentration in healthy individuals and patients with exercise-induced stable angina pectoris]. 263 Oct 72

Examinations were performed in 153 consecutive patients with myocardial infarction (MS), which were divided into two groups. Group I (21 persons) consisted of patients with echocardiographically diagnosed left ventricular mural thrombus, and in group II were patients without evidence of thrombi. Significantly more patients with anterior myocardial infarction were in the the group I, whereas those with inferior MI in the group II. Increased left ventricular wall contractility index and considerably percentage of dyskinesis, mostly of the apex region were stated in the group I. 15 patients (71%) of the group I were treated with heparin, but only 4 of them within 4 hours from the beginning of angina pain. In 4 patients of the group I (19%) thromboembolic complications occurred: in 1 patient during proper anticoagulant therapy and in 3 others without treatment with heparin. Thus mural thrombi were observed in majority in patients with anterior myocardial infarction and were localized in a diskinetic region. Echocardiograms of patients with mural thrombi testified to greater than in others left ventricular function impairment. Heparin administration during first hours of myocardial infarction seemed to lower the incidence of mural thrombi and probably thrombembolic complications.
Kardiol Pol 1989
PMID:[Left ventricular mural thrombi in myocardial infarction in echocardiographic studies and clinical observations]. 263 38

In 75 patients 24-hour ecg monitoring value was compared with exercise test in diagnostics of postinfarction silent ischemia. Results compatibility of both comparing examinations was 79% with regard to only painless ischemia (p less than 0.001) and 91% to both estimated painless or painful episodes (p less than 0.001). Painless ischemia was observed during ecg Holter monitoring and exercise test respectively in 39% and 35% of examined patients (NS) and/or with the angina respectively in 44% and 53% (p less than 0.01). 24-hour ecg monitoring and exercise test are of a comparable value in diagnosis of postinfarction silent ischemia, whereas in diagnostics of jointly estimated painless or painful ischemia the exercise test is a more sensitive examination than ecg Holter monitoring.
Kardiol Pol 1989
PMID:[Value of Holter monitoring and the electrocardiographic exercise test in the diagnosis of silent ischemia after myocardial infarction]. 263 20

Hypertension is a well known risk factor of coronary artery disease. The aim of the study was to evaluate a clinical course and prognosis in hypertensive patients with acute myocardial infarction (MI). 100 consecutive patients with acute MI underwent the study. In 38 of them (28 males and 10 females) a history of hypertension and intermittent rises of arterial blood pressure in a course of MI were stated. All patients underwent 2-DE examination and 24 hours Holter ecg monitoring. Clinical characteristics consisted of the heart failure and arrhythmias occurrence as well as the in-hospital mortality. Significantly higher rate of MI in the past and/or angina pectoris as well as a diabetes mellitus was stated in hypertensive patients. In these patients inferior, transmural MI was more often observed, while there was no difference in life-threatening arrhythmias, pulmonary edema and cardiogenic shock between normotensive and hypertensive patients.
Kardiol Pol 1989
PMID:[Myocardial infarction in patients with hypertension]. 281 Oct 21

Cardiac arrhythmias may often be of the thyroid origin. It is so-called thyroid-cardiac syndrome which may also be manifested by the circulatory failure and angina pectoris. The authors have been observed 54 cases of such arrhythmias; they have frequently been manifested by the paroxysmal tachycardia, extrasystolic beats, and paroxysmal or stable atrial fibrillation. Diagnosis of such arrhythmias may be difficult in case of the masked hyperthyroidism being its only clinical symptom. In order to establish a proper diagnosis the following tests of thyroid gland functioning have been carried out: TRH-TSH, scintigraphy and ultrasound examination of the thyroid gland. TRH-TSH test enables to detect disorders of hypophyseal-thyroidal regulation characteristic for both overt and masked hyperthyroidism. Scintigraphic examination reveals autonomic nodules of the thyroid glands being frequently a cause of cardiac arrhythmias. Ultrasound examination enables confirmation of the diagnosed autonomic thyroid nodules without TSH test. In the majority of cases of cardiac arrhythmias therapy with radioactive iodine isotope was introduced. Some patients with appropriate indications have been treated surgically after proper preparation. Pharmacological treatment in thyroid-cardiac syndrome produces transient and instable result.
Pol Tyg Lek
PMID:[Current diagnosis and treatment of cardiac arrhythmias of thyroid origin]. 281 77

Nitrates have been used in the pharmacological treatment of cardiac diseases for over hundred years, at the beginning in the treatment of angina pectoris. Later on the scale of clinical indications has widened towards other diseases where the vasodilating effect of these drugs could be of benefit. The increased interest in nitrates is based on new knowledge about their pharmacokinetics, pharmacodynamics and development of tolerance as well as the new idea of their cellular mode of action. They release nitric oxide, vasodilator and vasorelaxant physiologically originating from the vascular endothelium (EDRF). Nitrates and other NO-donors can substitute for this endogenous factor in the case of diseases endothelium or on other occasions where the production of NO is reduced or abnormally changed to toxic products. It is evident that totally new type of NO-donors like molsidomine and others will appear on the market for the treatment not only of cardiovascular diseases but also other disorders where smooth muscle relaxation is necessary. This review deals with the present status of nitrates in the cardiology and predicts some future aspects in this field.
Pol J Pharmacol
PMID:NO-donors in cardiology. 762 May 15


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