Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The changes of the plasma zinc, copper and erythrocyte glutathione peroxidase (GSH-Px) were measured by atomic absorption spectrometry and DTNB color development, in 31 patients suffering from coronary heart disease with angina Pectoris before and after taking Kuo-Guan granule one month. The results showed the plasma zinc was 16.83 +/- 2.60 mumol/L, copper 14.17 +/- 2.99 mumol/L, and erythrocyte GSH-Px 0.75 +/- 0.12 Eu/Hbmg/min in the normal control group. In patients with angina Pectoris, the plasma zinc was 14.39 +/- 4.44 mumol/L, copper 17.47 +/- 4.42 mumol/L, and erythrocyte GSH-Px 0.49 +/- 0.075 Eu/Hbmg/min before treatment; the plasma zinc was 20.17 +/- 3.97 mumol/L, copper 15.74 +/- 3.15 mumol/L, and erythrocyte GSH-Px 0.72 +/- 0.10 Eu/Hbmg/min after treatment. These results indicate that the plasma zinc and erythrocyte GSH-Px were lower and copper was higher in the patients than the normal control group before treatment (P less than 0.01), the plasma zinc and erythrocyte GSH-Px were increased and copper was decreased after treatment (P less than 0.01). These suggest that therapeutic mechanism of Kuo-Guan granule to coronary heart disease with angina Pectoris may be related to it's regulation on trace elements disturbance in body.
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PMID:[Effects of kuo-guan granule on plasma zinc, copper and erythrocyte GSH-Px (glutathione peroxidase) in patients with angina pectoris]. 239 54

Plasma selenium and plasma glutathione peroxidase were measured in 483 68-year-old men participating in a longitudinal population study, in which the probands were representatively selected. The prevalence of cancer and coronary heart disease was assessed by a structured interview. In plasma the concentration of selenium was 1.08 +/- 0.18 mumol X l-1 and the activity of glutathione peroxidase 540 +/- 90 mumol X l-1 X min-1. Plasma selenium was correlated to glutathione peroxidase activity (r = 0.49, p less than 0.001), but not significantly to plasma albumin levels (r = 0.18). Plasma selenium and glutathione peroxidase values in subjects with cancer or angina pectoris were not significantly different from those in subjects without these diseases. Plasma selenium concentration and glutathione peroxidase activity in the subjects who died within 1 year of screening were 89% and 88%, respectively, of the values among survivors (p less than 0.01). For the subjects who died during the second year after screening, these variables did not differ significantly from the values among survivors, 97% and 99%, respectively. Since the relation of low selenium and glutathione peroxidase to mortality was observed only for the first year, it was probably due to a disturbed nutritional state prior to death, rather than to a long-term negative influence of low plasma selenium on the mortality risk. Furthermore, the data have failed to demonstrate a relationship between selenium status and cancer or angina pectoris.
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PMID:Plasma selenium and glutathione peroxidase in relation to cancer, angina pectoris and short-term mortality in 68-year-old men. 345 86