Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty-two elderly men with coronary heart disease (CHD), 54 of them also suffering from hyperlipidemia, were treated with a new oral androgenic preparation (Andriol) through crossover study. The results showed that after oral Andriol administration for one month, serum estradiol/testosterone (E2/T) ratio was reduced, (P < 0.05) symptom of angina pectoris was relieved (total effective rate, 77.4%), signs of myocardial ischemia in ECG and Holter monitoring were improved (total effective rate, 68.8% and 75% respectively), serum total cholesterol (TC) and triglyceride (TG) levels were reduced dramatically (both P < 0.001) and the serum level of high density lipoprotein cholesterol (HDL-ch) was increased (P < 0.05), but the blood levels of apolipoprotein-AI (APO-AI) and B (APO-B) remained unchanged. No significant side effect of Andriol was observed.
Zhonghua Nei Ke Za Zhi 1993 Mar
PMID:[Antianginal and lipid lowering effects of oral androgenic preparation (Andriol) on elderly male patients with coronary heart disease]. 815 48

Esophageal investigation was performed successfully in 52 patients who were initially suspected of suffering from angina pectoris, but the pain was subsequently shown to be not of cardiac origin by radionuclide myocardiac perfusion and (or) coronary angiography in 74% of cases, and by EKG and poor response to anti-angina therapy in 26% of the cases. In 82.7% of the patients the diagnosis was gastroesophageal reflux disease (GERD), in 3.8% Nutcracker esophagus, and in 5.8% lower esophageal sphinctor hypertension. In the remaining 7.7% the diagnosis was unknown. In 43 patients with GERD, gastroesophageal reflux (GER) investigation showed GER symptoms in 61.5%, reflux esophagitis was confirmed with endoscopy in 45.3%. Abnormal esophageal manometry was found in 53.8%, positive provocative test in 42.9%, excessive radionuclide GER in 50%, and increased duration of hyperacidity in 57.1%. However, a combined study of the procedures mentioned above showed that the diagnosis was consistent with GERD in 82.3% of the patients. Chest pain was completely relieved in 34% of the cases and significantly relieved in 50%. No response was ilicited in 16% of the cases after 1-2 weeks of anti-reflux therapy. It is found that chest pain induced by GERD is very common, esophageal endoscopy and motor studies are helpful in the diagnosis of GERD and other esophageal motor diseases, and anti-reflux therapy is a reliable measure when a patient complains of unknown chest pain and GER symptoms.
Zhonghua Nei Ke Za Zhi 1993 May
PMID:[Diagnosis and treatment of angina-like chest pain in 52 cases]. 826 55

The clinical characteristics and coronary angiographic findings in 50 patients with spontaneous angina (SA) were studied. Coronary angiography did not disclose any severe fixed narrowing in 7 patients with SA only; the episodes of SA in these patients is the result of subtotal occlusion of a major coronary artery induced by spasm. 43 patients with both SA and effort angina (EA) had more severe coronary obstructive lesions. In these patients, the localization of electrocardiographic ischemia during episodes of SA and EA were always identical, indicating that the episodes of SA are related to the coronary narrowing lesions. Our study showed that incidence of SA was highest with 90% stenosis of the ischemia related artery, suggesting that besides coronary spasm, physiological coronary vasoconstriction or increase of coronary vasomotor tone could play an important role in the production of SA. In addition, turbulent flow, stasis, platelet aggregation and transient thrombosis might be individually responsible for episodes of SA in patients with severe coronary stenosis.
Zhonghua Nei Ke Za Zhi 1993 Jun
PMID:[Clinical characteristics and coronary angiographic findings of spontaneous angina]. 826 68

This study included 168 patients with angina pectoris, who were divided into two groups, the diltiazem SR (No. 88) group and diltiazem HCL (No. 80) group. The two groups were comparable in age and duration of coronary heart disease. The results were as follows: (1) The total clinical effect of diltiazem SR (94.3%) was slightly greater than that of diltiazem HCL (82.5%), the effect in ECG improvement was 53.3% and 53.4% respectively. (2) The rate of adverse effect was 12.5% in diltiazem SR group and 14.4% in diltiazem HCL group. It is concluded that the two different types of diltiazem have similar effect in the treatment of angina pectoris. However, it is more convenient to take diltiazem SR than diltiazem HCL as the former needs only twice a day.
Zhonghua Nei Ke Za Zhi 1993 Jan
PMID:[A comparison between diltiazem SR and diltiazem HCL in the treatment of angina pectoris]. 840 14

The long-term results of 68 cases of thyrotoxic heart disease (THD) treated with 131I were analysed. 17 of 68 patients have been followed for 2-4 years, 32 for 5-9 years, 7 for 10-14 years, 8 for 15-19 years and 4 for 20-33 years. The mean period of follow up was 9 years. Of the 68 patients, 47 did not respond to antithyroid drug (ATD) therapy. Before 131I therapy, all the patients suffered from one or more of cardiac abnormalities caused by hyperthyroidism such as paroxysmal or permanent atrial fibrillation, cardiac enlargement, cardiac failure, frequent atrial or ventricular extrasystoles, angina pectoris and so on. All patients were given individualized therapeutic 131I dose of 2.59-4.44 MBq per gram of thyroid weight. The total 131I dose for patients was 85.1 MBq to 462.2 MBq. The long-term results showed that 55 cases were cured and 11 cases achieved complete remission. The total effective rate was 97 percent. There was no relapse of hyperthyroidism. Except that 4 cases of early hypothyroidism and 5 of delayed hypothyroidism were diagnosed, there were no other complications. The incidence of postradioiodine hypothyroidism at 5-9 years was 7.4 percent and at 10-33 years 20 percent. Our results indicate that 131I is a simple, safe, economic and effective treatment for THD. Pre-treatment with ATD for hyperthyroidism with cardiac complications is not necessary. 131I should be considered as the treatment of first choice for hyperthyroidism with cardiac abnormalities.
Zhonghua Nei Ke Za Zhi 1995 Sep
PMID:[Long-term results following 131I treatment of thyrotoxic heart disease: a report of 68 cases]. 869 23

Our study population consisted of three groups: 1. 24 cases with ejection fraction (EF) > 45% in 26 patients with angina decubitus (AD) were studied as group A. 2. 20 patients had coronary artery disease without AD as group B. Group B and A were matched for age, EF and coronary artery obstructive lesions. 3. 20 cases without cardiovascular diseases as group C. Left ventriculography (LVG) was performed in these patients. The results showed that left ventricular (LV) early 1/3 filling fraction (1/3FF) was significantly reduced in group A as compared with that in group B and C (both P < 0.001). The findings suggest that patients with AD have abnormalities of LV diastolic filling. Left ventricular end diastolic pressure (LVEDP) significantly increased in patients with AD after LVG as compared with before LVG (P < 0.01). However, there was no statistically difference in LVEDP before and after LVG in both group B and C, indicating that the compliance of LV was also decreased in patients with AD. The increase of LV volume after recumbency would cause increase of LV wall tension and myocardial contraction and aggravate the LV diastolic dysfunction, resulting in a progressive increase in myocardial oxygen consumption. Therefore, we consider that on the basis of severe coronary artery obstructive lesions, LV diastolic dysfunction is a significant pathologic factor in the pathogenesis of AD.
Zhonghua Nei Ke Za Zhi 1995 Nov
PMID:[Left ventricular diastolic dysfunction in patients with angina decubitus]. 873 46

In order to study the characteristics of coronary lesions of patients with unstable angina, coronary angiograms and clinical manifestations were analysed on 388 patients. The results were as follows: single vessele disease was more common in new onset effort angina (69.64%) than in other groups (P < 0.05). Triple vessele disease and left main coronary artery lesion appeared more frequently in patients with rest angina than in other groups (72.34% and 27.66% respectively, P < 0.05), so did complex lesions and type C lesions (36.07% and 60.64% respectively, P < 0.05). More than half of the culprit lesions in early postinfarction angina was subtotal or total occlusions (53.12%), being more frequently found in this than in other groups (P < 0.05). Most of the patients with Prinzmetal variant angina had mild coronary lesions only. Coronary thrombi were found in 10.45% of the 388 patients; they were was more frequent in patients with early postinfarction angina (20.00%) than in the groups of new onset effort angina, aggravated effort angina and Prinzmetal variant angina (4.26%, 7.53% and 0% respectively, P < 0.05). Coronary thrombi were also more frequent in the patients with chest pain at rest (16.39%) than in the groups of new onset effort angina and Prinzmetal variant angina (P < 0.05). It is suggested that patients with angina at rest should be treated more intensively. Strengthened anticoagulation treatment should be given to patients with early postinfarction angina and angina at rest.
Zhonghua Nei Ke Za Zhi 1996 May
PMID:[Coronary angiographic characteristics of patients with unstable angina]. 938 14

In order to approach long-term efficacy of percutaneous transluminal coronary angioplasty (PTCA) and the factors affecting its efficacy in Chinese patients, 229 patients who underwent successful PTCA in this institution were followed by direct interview or letters. The rate of follow-up was 95% for the patients who should be followed. The period of follow-up was 0.5-8.4 (mean 2.3 +/- 1.8) years. Angina pectoris recurred in 76 (33.2%) of the patients. In 76% of the patients with recurrence, angina developed within 6 months after PTCA. Cox regression analysis revealed that the relative risk of recurrence of angina pectoris was increased among the patients with triple vessel disease and hypertension. During the period of follow-up, 2 (0.9%) patients died, 6 (2.6%) had non-fatal acute myocardial infarction, 4 (1.7%) had coronary artery bypass graft surgery, and 29 (12.7%) had repeat PTCA. The cardiac event free survival rate calculated by Kaplan-Meier method was 84.8% at 1 year and 70.5% at 8 years. Cox regression analysis revealed that there were positive correlations between stenosis of lesions before PTCA and residual stenosis of LAD after PTCA and the relative risks of cardiac events. In conclusion, the long-term efficacy of PTCA in Chinese patients was good. We suggest that to decrease the residual stenosis of LAD during procedure could probably decrease the relative risk of cardiac events during follow-up.
Zhonghua Nei Ke Za Zhi 1996 Dec
PMID:[Long-term prognosis of percutaneous transluminal coronary angioplasty in 229 cases]. 959 7

A series of 38 patients with variant angina in whom coronary arteriography was performed was reviewed to investigate the relation between coronary vasospasm and coronary obstructive lesions. 10 of the 38 (26.3%) patients had completely normal coronary arteriograms; 4 (10.5%) had insignificant coronary artery disease (< 50% stenosis); 24 (63.2%) had significant (> or = 50% stenosis) coronary artery disease, including single vessel disease in 12 cases, multiple vessel disease in 11 cases and left main trunk disease in one case. The results of this study showed that the incidence of coronary vasospasm increased with the severity of coronary stenosis and was highest at 75%-90% stenosis of the ischemia-related artery in those patients with significant coronary disease. In this study of 38 patients, coronary vasospasm involved the left anterior descending artery (LAD) in 25 patients (65.8%), right coronary artery (RCA) in 10 (26.3%) and left circumflex artery (LCX) in 2 (5.3%), but in patients with in significant stenosis (< 50%), LAD was involved in 50.0%, RCA in 42.9% and LCX in 7.1%. These results indicate that coronary vasospasm occurs frequently in patients with severe stenosis of the LAD.
Zhonghua Nei Ke Za Zhi 1996 Sep
PMID:[The relation between coronary vasospasm and coronary obstructive lesions in patients with variant angina]. 959 55


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