Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors quantified the change of CK-MM isoforms in the first available serum sample from 16 patients each with acute myocardial infarction (AMI) and angina pectoris and 16 normal individuals as well. The average MM3/MM1 ratio in the normal group was 0.24 +/- 0.12, in angina group 0.21 +/- 0.13, and in AMI group 0.52 +/- 0.30 (P less than 0.001, as compare with the first two groups). The first blood sample of AMI was obtained in 3.0 +/- 1.9 hours after the onset of chest pain. Half of them (8/16) had a ratio of MM3/MM1 greater than 0.50 and the change occurred as early as 30 min after the attack. In contrast, the total CK and CK-MB in the three groups were within normal limits at the same time, they were 85.8 +/- 24.4 U/L for CK and 3.2 +/- 1.1% for CK-MB in patients with AMI, 66.7 +/- 18.0 U/L, 2.7 +/- 1.6% in angina pectoris and 71.4 +/- 24.5 U/L, 3.0 +/- 1.1% in normal subjects respectively. Accordingly, diagnostic change of CK-MM isoforms was the earliest among the enzymes after the onset of AMI.
Zhonghua Nei Ke Za Zhi 1990 May
PMID:[Diagnostic changes in serum creatine kinase MM isoenzyme sub-bands after the onset of acute myocardial infarction]. 224 87

Fifteen patients with angina pectoris, seventeen with postmyocardial infarction angina and ten with normal coronary arteries were studied with stress TL-201 single photon emission computed tomography (SPECT). The sensitivity and specificity of SPECT for diagnosis of coronary heart disease were 91% and 90% respectively. SPECT showed better sensitivity (84%) for detecting diseased vessels. The sensitivity of SPECT for identifying one-vessel, two-vessel and three-vessel disease were 80%, 86% and 60%. The sensitivity and specificity of demonstrating involved coronary arteries by identifying the locations of myocardial perfusion defects were 79% and 92% for left anterior descending artery, 90% and 95% for left circumflex artery and 86% and 96% for right coronary artery. For localization of myocardial infarction in the posterior wall, posterior lateral wall, and posterior septum, SPECT is more accurate then ECG. The sensitivity of SPECT in detecting individual vessel is related to the severity of coronary stenosis. The more severe the coronary stenosis, the higher the sensitivity of SPECT. In conclusion, stress SPECT is a noninvasive, highly sensitive and accurate method for detecting and localizing coronary heart disease.
Zhonghua Nei Ke Za Zhi 1989 Jul
PMID:[Value of stress TL-201 myocardial single photon emission computed tomography in the diagnosis of coronary artery disease]. 259 Dec 55

572 cases have been examined with ambulatory electrocardiogram monitoring (AEM). They are divided clinically into three groups, (1) cases after myocardial infarction (2) cases with angina (3) cases without coronary artery disease (CAD). The incidences of silent myocardial ischemia (SMI) in the three groups were 80%, 24% and 3% respectively. The ratios of silent myocardial ischemia to symptomatic myocardial ischemia in groups (1) and (2) were 88.8% and 70.4%. It is shown that silent myocardial ischemia is very frequent in CAD. The article also reviewed and discussed the criteria for diagnosis of SMI, the mechanism of its presence, and its relation to degree of ST segment depression and daily activities.
Zhonghua Nei Ke Za Zhi 1989 Jul
PMID:[A preliminary report on silent myocardial ischemia detected using ambulatory electrocardiogram monitoring]. 259 Dec 56

Clinical, hemodynamic, and angiographic data were examined in 53 patients who underwent catheterization within 6 months of a documented first acute transmural myocardial infarction. The patients were divided according to the presence (23 patients) or absence (30 patients) of angina pectoris 1 month after infarction (group I and group II). Group I patients had more severe coronary artery disease and a greater prevalence of multivessel disease than group II patients. Partial preservation of segmental wall function in group I was related to the presence of collateral vessels. In patients with single vessel disease, the incidence of spontaneous recanalization of the infarct-related artery was higher in group I as compared with that in group II. It is concluded that angina pectoris after myocardial infarction suggests multivessel disease or infarct-related artery recanalization. Coronary arteriography may be advised in order to select adequate therapeutic interventions and improve prognosis in these patients.
Zhonghua Nei Ke Za Zhi 1989 Nov
PMID:[Value of angina pectoris after myocardial infarction in predicting the extent of coronary artery disease]. 263 76

The activity of serum superoxide dismutase (SOD) was studied in 35 cases of acute myocardial infarction (AMI) and 12 cases of angina pectoris (AP). The results suggested that serum MnSOD activity reached its peak value (18.7 +/- 6.39) immediately after AMI attack and gradually dropped down on the second day. The activity was no more detected on the seventh day. The value of serum MnSOD in patients with AMI within 24 hours was significantly different (P less than 0.05) or very significantly different (P less than 0.01-0.001) from that in patients with AMI after 2 days and AP and in the control group. The positive rate of early diagnosis in the three groups was 100%, 71% and 66% respectively. It was found that the height of serum MnSOD activity was closely correlated with the seriousness of myocardial damage, therefore, serum MnSOD activity may be one of the sensitive indices for the early diagnosis of AMI. In has also certain clinical value in the judgement of the extent of infarction and of prognosis.
Zhonghua Nei Ke Za Zhi 1989 Dec
PMID:[Dynamic changes of superoxide dismutase in patients with myocardial infarction. A clinical study]. 263 86

The degree of platelet activation and damage in 15 cases with acute myocardial infarction (AMI) receiving thrombolytic therapy and 15 cases with AMI receiving anticoagulant therapy were studied in vivo and in vitro by using specific monoclonal antibodies (SZ-51 & S12) against alpha-granule membrane protein 140 (GMP-140). Clinical indexes and myocardial enzyme changes in the two groups of patients were also observed. The results showed that the number of GMP-140 molecules on platelet surface and the concentration of GMP-140 in plasma were increased before treatment. The number of GMP-140 molecules on platelet surface began to decrease on the 1st day and returned to baseline on the 7th day after treatment. The concentration of GMP-140 in plasma reached a peak on the 1st day, began to fall on the 2nd day and returned to baseline on the 3rd day after treatment. There were no significant differences in the dynamic changes of number of GMP-140 molecules on platelet surface and the concentration of GMP-140 in plasma between groups of thrombolytic therapy and anticoagulant therapy. In vitro experiment showed that the thrombolytic medicine urokinase neither activated platelets nor inhibited platelet activation induced by thrombin. Significantly greater reperfusion rate and earlier appearance of CK and CK-MB peaks were found in the thrombolytic than in the anticoagulant group. LVEF determined by echocardiography, rate of return of ST segments to baseline and alleviation rate of chest pain were significantly greater and complications of AMI (ventricular fibrillation, left ventricular failure and angina) were less in the group receiving thrombolytic therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
Zhonghua Nei Ke Za Zhi 1995 Apr
PMID:[Dynamic observation of alpha-granule membrane protein 140 during the treatment of thrombolytic and anticoagulant therapy in patients with acute myocardial infarction]. 758 6

Fourty two patients with coronary artery disease were studied. Among them 22 were treated with continuous perfusion percutaneous transluminal coronary angioplasty (CPPTCA) and 20 with percutaneous transluminal coronary angioplasty (PTCA). It was found that patients treated with CPPTCA can stand longer time of dilatation during operation than those treated with PTCA (P < 0.01). Moreover, angina pectoris and ischemic changes of ECG occurred later during CPPTCA than during PTCA (P < 0.001). The incidences of ventricular tachycardia, ventricular fibrillation, residual trans-stenosis pressure gradient and residual stenosis were all lower in patients treated with CPPTCA than those with PTCA (P < 0.01-0.001). However, there was no significant difference in the incidence of reinfarction and one-year mortality between the patients after CPPTCA and PTCA.
Zhonghua Nei Ke Za Zhi 1994 Nov
PMID:[The clinical value of continuous perfusion percutaneous transluminal coronary angioplasty in treatment of coronary artery disease]. 760 Aug 71

The necropsy findings of 18 patients with cor pulmonale and coronary heart disease (CHD) were compared with those of a control group of 30 patients with cor pulmonale alone. The results showed that there was no significant statistical difference between the two groups on average heart weight and average left and right ventricular thickness (P > 0.05). The results suggest that at the end stage of cor pulmonale left ventricule may be involved whether there are complicating left ventricular disease or not. In this study, cor pulmonale and CHD were both accurately diagnosed in 33.3%, CHD failed to be diagnosed in 38.9% and cor pulmonale failed to be diagnosed in 27.8% of the patients. Single diagnostic factor analysis for cor pulmonale with CHD indicated that age, history of hypertension, history of angina pectoris, history of MI, accentuation A2, presence of bundle branch block, abnormal Q wave and left axis or normal deviation, Cheng Xiansheng diagostic criteria and Selvester MI screening criteria are of significance (P < 0.05). Multiple factor logistic regression analysis indicated that independent prognostic factors including history of angina pectoris, Selvester MI screening criteria and Cheng Xiansheng diagnostic criteria are of help for diagnosis (P < 0.03-0.000). The above-mentioned diagnostic methods are, however, not so specific. At present the best method for diagnosis of CHD is coronary arteriography.
Zhonghua Nei Ke Za Zhi 1995 Mar
PMID:[A clinicopathological study of cor pulmonale with coronary heart disease]. 764 41

The clinical and echocardiographic variables related to postinfarction angina were evaluated in 54 patients with acute myocardial infarction. All patients underwent 2D echocardiography at 2-3 weeks after infarction. Wall motion analysis was quantified with a wall motion score index (WMSI) based on 16 left ventricular wall segments. Among the 54 patients with acute myocardial infarction 23 (42.6%) had early postinfarction angina. Multiple regression analysis demonstrated no significant difference between the patients with and without postinfarction angina in age, sex, location of infarction, Killip classification, previous angina, hypertension, hyperlipidemia, diabetes mellitus, creatine kinase level and left ventricular ejection fraction. In comparison with patients without postinfarction angina, patients with postinfarction angina had higher WMSI. It indicates that postinfarction angina appears to be related more to myocardial ischemia rather than to the infarct of myocardium.
Zhonghua Nei Ke Za Zhi 1994 Aug
PMID:[Analysis of risk factors in postinfarction angina]. 788 38

Three cases of diabetic myocardiopathy having history of diabetes, angina and left ventricular dysfunction of various degrees and confirmed by coronary angiography and endomyocardial biopsy were reported. Electrocardiography showed significant ST-T changes simulating coronary insufficiency but without definite localization. As to the treatment, nitrate preparations, inotropic agents such as strophanthin K, digoxin etc. were used to relieve the symptoms; insulin was also administered to control the blood glucose level. Diltiazem, a calcium blocker, is also of help in alleviating the symptoms. It is shown in the present study and in the literatures as well that diabetic myocardiopathy is a disease showing intramural microvascular endothelial proliferation and swelling as well as subendothelial accumulation of acid glycogen deposition cells. The transportation of intracellular calcium ions and the cellular metabolism are thus affected, so there are extensive ischemia, focal necrosis and fibrosis in the myocardium with resulting cardiac dysfunction. The authors are, therefore, of the opinion that diabetic myocardiopathy is a specific and separate clinical entity.
Zhonghua Nei Ke Za Zhi 1994 Jan
PMID:[Diabetic myocardiopathy]. 804 81


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