Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Autoimmune responses to myoglobin were studied in patients with myocardial infarction at different disease stages. It was revealed that during myocardial infarction, the clone of lymphocytes reacting with myoglobin was activated. Besides, these patients showed sensitized T lymphocytes with high cytotoxic activity, lymphotoxins and leukocyte migration inhibition factor, attesting to the development of the delayed type hypersensitivity to myoglobin. It was demonstrated that lymphotoxin assay in the blood might be of importance for differential diagnosis of acute myocardial infarction and angina pectoris with a long-term painful syndrome.
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PMID:[Autoimmune reactions to myoglobin in myocardial infarct patients]. 633 8

Development of acute coronary syndrome(ACS) including angina pectoris(AP) and myocardial infarction(MI) depends on complex interactions of environmental and genetic factors. In 2000, we started a genome wide association study(GWAS) for MI using nearly 100,000 gene-based single nucleotide polymorphisms(SNP), and identified lymphotoxin a (LTA) conferring risk of MI in Japanese population. This is the first study identified a disease susceptibility gene on genome wide with SNP in the worldwide. Moreover, through examining the LTA cascade by combination of biological and genetic analyses, we have identified additional MI susceptible genes, LGALS2, PSMA6 and BRAP, so far. On the other hand, recent advances in the development of cheap and accurate high throughput genotyping technologies, as well as the accumulation of information for a large set of SNP and their linkage disequilibrium by the HapMap projects(http://www. hapmap.org; The International HapMap Consortium 2005) permit us to assess the GWAS more systematically and comprehensively. Through the systematic GWAS with in individuals from European decent, genetic variants that confer susceptibility to ACS have been identified to be present on many chromosome loci. In this review, genetic background of ACS is discussed.
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PMID:[Genetic background of acute coronary syndrome]. 2038 50