Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of intensive exercise (IE) on plasma lipoproteins was assessed in patients with angina of new onset (first three months). A six-week IE course increased stress tolerance. Total cholesterol (CS), triglycerides (TG), low-density lipoprotein cholesterol (LDLP CS) levels dropped significantly. High-density lipoprotein cholesterol (HDLP CS) remained unchanged, yet the total CS-HDLP CS/HDLP CS ratio dropped significantly after 6 weeks of training, with total CS, TG and the total CS-HDLP CS/HDLP CS ratio already decreasing significantly within 2 weeks. After six weeks of exercise, apo-B level remained unchanged, apo-AI level rose significantly, and the apo-B/apo-AI ratio decreased significantly. Positive shifts in plasma lipid and apoprotein spectrum resulted in a decrease of lipoprotein atherogenic characteristics.
 ...
PMID:[Newly developed stenocardia: effect of intensive physical training on the lipoprotein spectrum of blood plasma]. 314 23

The serum lipoprotein profile was determined in 37 patients with chronic ischemic heart disease (IHD) and 100 practically healthy subjects, aged from 18 to 45. HLP was found in 59.5 per cent of the patients examined, 50 per cent in males and 100 per cent in females. Type IV has the highest incidence (54.5%), followed by type IIB(36.4%) and type IIa (9.1 per cent). In 27 per cent of the patients with no HLP determined, less significant changes in LDLP and VLDLP were found, admitted to be dyslipoproteinemia (DLP). HLP and DLP were confirmed in 86.5 per cent of the patients examined. In all patients serum concentration of HDLP-Chol was decreased (mostly in DLP and type IV HLP), whereas the level of HDLP-Tg was increased in most of the cases. As a result, the intralipoprotein index 1(2)(=HDLP-Chol/HDLP-Tg) was decreased, reaching the lowest values in IIa and type IV HLP. The only index of all studied, being changed (elevated) with a statistical significance in all groups of patients with IHD, in those with normolipoproteinemia (NLP) including, was the lipoprotein index II(=LDLP-Chol and VLDLP-Chol/HDLP-Chol). With the morbid process progressing, assessed by ECG data, the functional stage of stenocardia, the degree of the constriction and the number of the pathologically altered coronary arteries, the incidence of NLP, DLP and type IV HLP distinctly decreased, whereas IIa and IIB type HLP increased.
 ...
PMID:[Changes in serum lipoproteins in patients with ischemic heart disease at an early age]. 710 95