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To assess the ACC/AHA task force grading system as a predictor of outcome in patients undergoing multivessel percutaneous transluminal coronary angioplasty we analyzed all failures (residual stenosis > 50%, Q-wave myocardial infarction, coronary artery bypass grafting during hospitalization, or death) in 97 patients with 328 stenoses. There were 70 males and 27 females; 60 patients had stable angina, and 37 had unstable angina. The mean number of lesions dilated per patient was 3.4 (range 2-8). The mean preangioplasty percent luminal diameter narrowing was 80 +/- 14%. Thirty-eight stenoses were AHA/ACC classification type A, 192 type B, and 98 type C. One hundred twenty-eight lesions were located in the left anterior descending artery or its distribution, 89 in the left circumflex, 96 in the right coronary artery, and 15 in other vessels. Procedural success (< 50% residual diameter narrowing and no major ischemic complications) was achieved in 266 lesions (81.1%). Major ischemic complications (death, myocardial infarction, or emergency bypass surgery) occurred in 8 patients (8.2%) and in-hospital mortality was 2%. Analysis on a per stenosis basis demonstrated 84% success in type A, 89% in type B, and 64% in type C (p < 0.0001). When type B was divided into type B1 (1 type B characteristic) and type B2 (two or more type B characteristics) the success rate was 90% vs. 88% and the complication rate was 1% vs. 2%, respectively (p = n.s.). Logistic regression analysis showed that the best single predictor of failed angioplasty was total occlusion > 3 months, followed by total occlusion < 3 months and severely angulated (> 90 degrees) segment.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Does the AHA/ACC task force grading system predict outcome in multivessel coronary angioplasty? 144 43

BACKGROUND. Acute closure remains a significant limitation of percutaneous transluminal coronary angioplasty (PTCA) and underlies the majority of ischemic complications. This study details the clinical and angiographic characteristics of a series of patients receiving an intracoronary stent device to manage acute and threatened closure and presents the early clinical results. METHODS AND RESULTS. From October 1989 through June 1991, 115 patients undergoing PTCA received intracoronary stents to treat acute or threatened closure in 119 vessels. Sixty-three percent had multivessel coronary disease, 33 (29%) had undergone prior coronary artery bypass grafting (CABG), and 52 (45%) had had previous PTCA. Using the American College of Cardiology/American Heart Association (ACC/AHA) classification, 15% of lesions were class A, 55% were class B, and 30% were class C. Eight patients were referred with severe coronary dissection and unstable angina after PTCA at other institutions. Acute closure was defined as occlusion of the vessel with TIMI (Thrombolysis in Myocardial Infarction) 0 or 1 flow immediately before stent placement. Threatened closure required two or more of the following criteria: 1) a residual stenosis greater than 50%, 2) TIMI grade 2 flow, 3) angiographic dissection comprising extraluminal dye extravasation and/or a length of greater than 15 mm, 4) evidence of clinical ischemia (either typical angina or ECG changes). Twelve vessels (10%) met the criteria for acute closure, and 87 vessels (73%) satisfied the criteria for threatened closure. Twenty vessels (17%) failed to meet two criteria. Stenting produced optimal angiographic results in 111 vessels (93%), with mean diameter stenosis (+/- 1 SD) reduced from 83 +/- 12% before to 18 +/- 29% after stenting. Overall, in-hospital mortality was 1.7% and CABG was required in 4.2%; Q wave myocardial infarction (MI) occurred in 7% and non-Q wave MI in 9%. Stent thrombosis occurred in nine patients (7.6%). For the 108 patients who presented to the catheterization laboratory without evolving MI, Q wave MI occurred in 4% and non-Q wave MI occurred in 7%. Angiographic follow-up has been performed in 81 eligible patients (76%), and 34 patients (41%) had a lesion of greater than or equal to 50%. CONCLUSIONS. This stent may be a useful adjunct to balloon dilatation in acute or threatened closure. Randomized studies comparing this stent with alternative technologies are required.
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PMID:Intracoronary stenting for acute and threatened closure complicating percutaneous transluminal coronary angioplasty. 153 28

To assess the likelihood of procedural success in patients with multivessel coronary disease undergoing percutaneous coronary angioplasty, 350 consecutive patients (1,100 stenoses) from four clinical sites were evaluated. Eighteen variables characterizing the severity and morphology of each stenosis and 18 patient-related variables were assessed at a core angiographic laboratory and at the clinical sites. Most patients had Canadian Cardiovascular Society class III or IV angina (72%) and two-vessel coronary disease (78%). Left ventricular function was generally well preserved (mean ejection fraction, 58 +/- 12%; range, 18-85%) and 1.9 +/- 1.0 stenoses per patient had attempted percutaneous coronary angioplasty. Procedural success (less than or equal to 50% final diameter stenosis in one or more stenoses and no major ischemic complications) was achieved in 290 patients (82.8%), and an additional nine patients (2.6%) had a reduction in diameter stenosis by 20% or more with a final diameter stenosis 51-60% and were without major complications. Major ischemic complications (death, myocardial infarction, or emergency bypass surgery) occurred in 30 patients (8.6%). In-hospital mortality was 1.1%. Stepwise regression analysis determined that a modified American College of Cardiology/American Heart Association Task Force (ACC/AHA) classification of the primary target stenosis (with type B prospectively divided into type B1 [one type B characteristic] and type B2 [greater than or equal to two type B characteristics]) and the presence of diabetes mellitus were the only variables independently predictive of procedural outcome (target stenosis modified ACC/AHA score; p less than 0.001 for both success and complications; diabetes mellitus: p = 0.003 for success and p = 0.016 for complications). Analysis of success and complications on a per stenosis dilated basis showed, for type A stenoses, a 92% success and a 2% complication rate; for type B1 stenoses, an 84% success and a 4% complication rate; for type B2 stenoses, a 76% success and a 10% complication rate; and for type C stenoses, a 61% success and a 21% complication rate. The subdivision into types B1 and B2 provided significantly more information in this clinically important intermediate risk group than did the standard ACC/AHA scheme. The stenosis characteristics of chronic total occlusion, high grade (80-99% diameter) stenosis, stenosis bend of more than 60 degrees, and excessive tortuosity were particularly predictive of adverse procedural outcome. This improved scheme may improve clinical decision making and provide a framework on which to base meaningful subgroup analysis in randomized trials assessing the efficacy of percutaneous coronary angioplasty.
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PMID:Coronary morphologic and clinical determinants of procedural outcome with angioplasty for multivessel coronary disease. Implications for patient selection. Multivessel Angioplasty Prognosis Study Group. 240 Oct 82

In order to clarify the relationship between characteristics of lesions and the immediate outcome after percutaneous transluminal coronary angioplasty (PTCA) in Chinese patients, 170 cases of PTCA performed in this institution from December 1986 to July 1993 were analysed. There were 149 cases of angina pectoris, 75 complicated with old myocardial infarction; 21 cases of acute myocardial infarction (AMI) including 8 complicated with cardiogenic shock, PTCAs were performed under assistance of IABP in 4 and under assistance of centrifugal pump in 1.236 lesions, including 15 lesions of total occlusion in AMI, 27 of chronic total occlusion and 9 lesions in bifurcation using double balloon technique, were attempted to be dilated. 213 (90.3%) of 236 lesions were successfully dilated. According to the standard set by the report of ACC/AHA task force, the success rate in type A lesions was 47/48 (97.9%), in type B lesions 136/151 (90.1%) and in type C lesions 30/37 (81.1%). The success rate in type A lesions was significantly higher than that in type C lesions (P < 0.01). In 7 of 8 patients with cardiogenic shock complicating AMI, PTCA was successful. 4 of the 7 survived. The major factors for failure in dilatation included chronic total occlusion, excessive tortuosity of proximal segment, eccentric and tubular lesions, etc. Acute occlusion occurred in 2 cases with type C and 1 with type B lesion, one patient died after 24h of emergency CABG. In one patient complicated with acute closure and 2 with threatened closure Gianturrco-Roubin stents were implanted and the patency of the vessels were maintained.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Percutaneous transluminal coronary angioplasty: relationship between the characteristics of the lesions and the immediate outcome]. 804 25

The purpose of this study was to evaluate prospectively the efficacy and safety of mobile cardiac catheterization. Mobile cardiac catheterization was introduced into clinical practice in 1989, but there has been no systematic study of its performance and safety. A registry was established in 1989 to monitor outcomes with mobile cardiac catheterization and is reported here. Patients were screened for eligibility for mobile cardiac catheterization using the joint AHA/ACC criteria for outpatient angiography. Eligible patients underwent mobile catheterization at eight hospitals within 120 miles of the base tertiary center. Helicopter evacuation services were available at each mobile site. The indications, findings, dispositions, and complications of mobile cardiac catheterization were recorded by means of a checklist, telephone follow-up and chart review. A total of 1,001 consecutive patients were entered into the registry in the first 20 months of operation, including 436 females and 565 males aged 22 to 84 years. Angina (Canadian Classes II-IV) was the most frequent primary indication for catheterization (46.4%), followed by atypical chest pain (36.9%), or a positive exercise stress test (25.6%). Infrequent indications for catheterization included a history of myocardial infarction (5.6%), congestive heart failure (7.1%), arrhythmias (4.1%), and valvular heart disease (0.7%). Catheterization was accomplished in 99.9% of patients. Angiographically normal studies were observed in 22.8%, and mild (< or = 50%) coronary artery disease in 13.6% of patients.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Mobile cardiac catheterization registry: report of the first 1,001 patients. 811 52

The study group included 1,553 consecutive patients from areas serviced by our mobile catheterization laboratories: 719 procedures were performed in the mobile unit at their local hospitals, 277 were performed at a tertiary hospital with less than a 24 hr hospital stay, and 557 were performed at a tertiary hospital as inpatients. The indications for mobile catheterization were predominantly atypical chest pain, angina pectoris, or positive treadmill stress test, whereas patients with less than 24 hr hospitalization at the tertiary center had their catheterization performed for additional reasons. The majority of the inpatient indications were for recent myocardial infarction or unstable angina. Using the American College of Cardiology/American Heart Association (ACC/AHA) criteria for outpatient catheterization, the mobile catheterizations were performed safely with a complication rate of only 0.7% compared to a complication rate of 3.1% for inpatients demonstrating that a low risk group of patients can be prospectively identified and catheterized safely in the mobile setting. An extremely high risk group of patients with ongoing unstable angina and recent myocardial infarction was also identified which should undergo catheterization only at a tertiary center.
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PMID:Mobile cardiac catheterization: comparison with outpatient and inpatient catheterization at tertiary facilities. 811 64

The Multi-Link coronary stent (Advanced Cardiovascular Systems, Santa Clara, CA) is a balloon expandable stent carved from a stainless steel cylinder and is composed of 12 corrugated rings connected by multiple links. This design gives the stent great flexibility and conformity as well as radial strength. For the 3 month period from November 1995 to January 1996, all patients undergoing stent implantation in our institution were treated with this device, except for vessels smaller than 2.7 mm or larger than 3.7 mm in diameter, left main disease, or those who could not tolerate anticoagulation therapy. Forty patients, with a total of 42 arteries or 44 lesions, were treated with 56 stents, or 1.33 stents per artery. Clinical presentation included stable angina in 13 (32.5%), unstable angina in 24 (60%), acute myocardial infarction in 2 (5%), of whom 1 was in cardiogenic shock, and atypical symptoms with an abnormal thallium stress test in 1 (2.5%). According to the American College of Cardiology/ American Heart Association (ACC/AHA) classification, 8 lesions (18%) were type A, 14 (32%) type B1, 11 (25%) type B2, and 11 (25%) type C. Forty-three lesions (97.7%) were de novo and 1 (2.3%) restenotic. Stent delivery was successful in all patients. Complications included 1 balloon rupture at 7 atm but without sequelae, and 2 patients in whom the coronary guide wire became kinked and locked inside the catheter shaft of the stent delivery system but stent delivery was eventually successful. Mean diameter stenosis was reduced from 76 +/- 13% presenting to 2 +/- 9% poststenting and minimal lumen diameter increased from 0.87 +/- 0.38 to 2.82 +/- 0.34 mm. There were no acute-subacute stent thromboses, bleeding/vascular complications, or major cardiac events such as myocardial infarction, coronary artery bypass surgery, or death during a follow-up period of 2-5 months (mean 3.6 months). In conclusion, our early clinical experience with the Multi-Link stent is very encouraging, with a very high rate of successful delivery and minimal complications.
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PMID:Early clinical experience with the Multi-Link coronary stent. 895 35

Between April and December 1996, 50 less-shortening Wallstents were deployed in the native coronary arteries of 44 patients, with lesions more than 20 mm long and minimum vessel diameter of at least 3.0 mm. There were 39 males and 5 females with an age range of 35-77 years. The majority (70.4%) had multivessel disease (MVD). The target vessel was LAD for 17 (34%), RCA 23 (46%) and LCx-OM for 10 (20%) stents. All lesions were type C, according to the ACC/AHA Task Force Classification. The length of the lesions ranged from 21-60 mm (mean: 31 +/- 8). The stent selection was based upon oversizing by 1.5-2.0 mm compared to the minimum vessel diameter, and covering approximately 4-5 mm of the apparently normal vessel on either side of the target lesion. The stent was deployed successfully without any major complications, including myocardial infarction, emergency coronary artery bypass grafting (CABG) and death in 43 out of 44 (97.7%) patients. One patient in whom there was failure to reach the target site with stent, developed non-Q wave inferior myocardial infarction. Post-discharge, two patients reported to have died within one month after the procedure. The event-free survival, defined as the absence of angina, myocardial infarction, need for revascularisation or death was 93.2 percent at 30 days and 84 percent at 6 months following stent implantation. From our data, it is concluded that (i) the delivery of the new, less-shortening, self-expanding Wallstent at the target site was possible in almost all the cases; (ii) clinical success with < 30 percent residual diameter stenosis could be achieved in approximately 98 percent of cases, and (iii) there was an impressive event-free survival of 84 percent at 6 months of follow-up. The occurrence of 2 deaths during the first 30 days, however, necessitates close supervision for possible subacute stent thrombosis. The results of angiography after six months would help to define the true incidence of restenosis.
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PMID:Immediate and six-month outcome of self-expanding Wallstent for long lesions in native coronary arteries. 913 Apr 26

The evaluation and management of heart disease in patients about to undergo noncardiac surgery begins with a careful history and physical examination, including an assessment of clinical risk for perioperative myocardial infarction and/or death. Patients can be categorized into major, intermediate, minor or low clinical risk groups, based on clinical markers such as past myocardial infarction, congestive heart failure, angina or diabetes. Additional evaluation includes estimation of surgery-specific risk, prior coronary evaluation and/or revascularization, and level of functional capacity. Based on these parameters, physicians can decide to engage in further noninvasive testing to assess left ventricular function and/or risk of perioperative ischemia in a small, selected group of patients. Rarely, patients may meet criteria for perioperative coronary revascularization followed by noncardiac surgery. Perioperative medical therapy relies heavily on the use of beta blockers. Postoperative cardiac surveillance must be tailored to the individual patient. The use of pulmonary arterial catheters, the type of anesthesia and the assessment of long-term cardiac risk are also discussed in this summary of the ACC/AHA Guidelines.
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PMID:Surgical patients with heart disease: summary of the ACC/AHA guidelines. American College of Cardiology/American Heart Association. 930 74

In 1995, from 12 participating units, there were 1108 PTCA compared to 697 in 1994, 24 rotational atherectomy and 109 intracoronary stent placements performed. These were complicated by 6 acute myocardial infarction, 10 emergency surgeries and 11 deaths. Success rate was 92 per cent. Indication for transcatheter revascularization were stable angina pectoris in 60 per cent of cases, unstable angina in 18 per cent and post infarct angina in 16 per cent. Thirty cases were done in AMI setting. Of those 1108 vessels approached, 1297 lesions were in native arteries and 9 were in saphenous vein grafts. Most lesions were in AHA/ACC type B category. One hundred and fourteen stents were placed in 109 patients in 1995. Seven stents emboli occurred in addition to one myocardial infarction, 2 CABG, 2 death and 2 major bleeding. Transcutaneous coronary revascularization has increased in number with acceptable results. Coronary stenting was done in an average of 10 per cent of all procedures and also with reasonable complication rates.
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PMID:Transcatheter coronary revascularization registry 1995. 938 63


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