Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A method of examination for coronary artery disease that is less invasive and easier than coronary angiography (CAG) has been sought. We have developed a dynamic intravenous coronary angiography (IVCAG) system using synchrotron radiation (SR) and have used it clinically. Four patients suspected of having angina pectoris underwent IVCAG. An SR beam was reflected asymmetrically with a silicon crystal to produce a wide (150 mm x 80 mm) and monochromatic (37 keV) X-ray beam, with an energy level to achieve high sensitivity to the contrast agent. Following an intravenous injection of contrast agent, irradiation was applied for 4 ms periods at 33 ms intervals for dynamic IVCAG at 30 images s-1. Images were acquired with an image intensifier and recorded with a digital fluorography system. The dynamic images permitted clear visualization of the coronary arteries and permitted evaluation of coronary anatomy. Two patients exhibited no stenotic lesions, one patient had a 90% stenosis in the right coronary artery, and the remaining patient had a 25% stenosis at the site of previous percutaneous transluminal coronary angioplasty in the left anterior descending artery (LAD). The total irradiation doses used for IVCAG were less than those for conventional angiography. Dynamic IVCAG can be readily used for the evaluation of coronary arteries.
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PMID:Dynamic intravenous coronary angiography using 2D monochromatic synchrotron radiation. 1034 85

The hemocompatibility and biocompatibility of a stent are determined by the physical and electrochemical properties of the stent surface. The aim of this study was to determine the feasibility, safety and efficacy of implantation of a stent coated with silicon carbide. Baseline characteristics were collected prospectively. The occurrence of cardiac adverse events and the angina score were assessed at clinical follow-up. A total of 193 Tensum stents were implanted in 174 patients. In hospital, one patient experienced stent thrombosis and in 6% of the patients a creatinine kinase elevation to 240 U/l or more occurred. Long-term follow-up was performed in 172 patients, with a mean follow-up of 454 +/- 181 days. Ninety-seven per cent were still alive, 15% had undergone target-vessel revascularization, and 2% had angiographic restenosis and were treated with medication only. Seventy-one per cent of the patients were free of anginal complaints, and 20% had anginal complaints in Canadian Cardiac Society class I or II. The Tensum coronary stent showed to be a safe and efficacious device in this study, with a high primary success rate and favorable long-term clinical followup.
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PMID:Initial results and long-term clinical follow-up of an amorphous hydrogenated silicon-carbide-coated stent in daily practice. 1262 96

Silicon carbide (aSIC-C) is a stent coating with antithrombogenic as well as anti-inflammatory properties as compared with uncoated stainless steal based on in vitro and in vivo studies. This study investigated the potential of this coating in patients with unstable angina. At 38 study sites, 485 patients were randomized to an aSIC-C (n = 238) or a conventional stainless steal stent (n = 247). Patient were classified according to angina at rest within last 48 hr to Braunwald in class IIB (= 314) and IIIB (n = 171). The primary endpoint was a combination of death, myocardial infarction, or ischemia-driven target vessel revascularization at 6 months. Complications of procedures performed at 0.4 +/- 1.1 days after admission occurred at lower rates than previously reported in this high-risk population, but the primary endpoint was not different between the study groups. Only in Braunwald class IIIB patients did the primary endpoint occur less frequently in patients with an aSIC-C stent as compared to patients with a conventional stent (5.8% vs. 15.3%; P = 0.049). At 9-month follow-up, the level of difference was maintained, but statistical significance was lost. Quantitative angiography revealed no significant difference between the stents in the subgroups. This study suggests that aSIC-C stents exert clinically measurable effects in patients with unstable angina with recent symptoms at rest. This coating deserves further clinical investigation and may serve as platform for antiproliferative drugs.
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PMID:Silicon carbide-coated stents in patients with acute coronary syndrome. 1457 90