Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002962 (
angina
)
21,142
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study, asymmetric poly(4-methyl-1-pentene) (
TPX
) membranes, fabricated by the dry/wet inversion method, were applied to transdermal delivery of nitroglycerin (NTG), a drug for treating
angina pectoris
. The flux of NTG through the
TPX
membrane was measured in vitro by a Franz cell. The results indicate that the NTG flux through asymmetric
TPX
membranes is strongly dependent on the membrane structure, which can be varied by adding nonsolvents in the casting solution. By adding different kinds of nonsolvents and adjusting the added amounts, membranes with different NTG release rates can be fabricated. It was also found that, with suitable drug formula, the NTG dissolution rate of a prototype
TPX
patch is comparable to that of a commercial patch, Transderm-Nitro. In addition, the data of NTG flux through a composite of
TPX
membrane and pig skin are also presented.
...
PMID:Application of asymmetric TPX membranes to transdermal delivery of nitroglycerin. 968 85
