Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There is no established treatment specifically aimed at protecting or restoring cardiac energy metabolism, which is greatly impaired by ischaemia. Even after reperfusion, myocardial content of ATP remains low for more than 72 h. Long-term post-ischaemic dysfunction and irreversibility of ischaemic damage have been associated with low ATP content. Evidence that the pentose sugar ribose stimulates ATP synthesis and improves cardiac function led us to test the possibility that ribose increases tolerance to myocardial ischaemia in patients with coronary artery disease (CAD). 20 men with documented severe CAD underwent two symptom-limited treadmill exercise tests on 2 consecutive days; we postulated that the ischaemia induced might bring about changes in ATP metabolism lasting for several days. Patients whose baseline tests showed reproducibility were randomly allocated 3 days of treatment with placebo or ribose 60 g daily in four doses by mouth. Exercise testing was repeated after treatment on day 5. At that time mean (95% confidence interval) treadmill walking time until 1 mm ST-segment depression was significantly greater in the ribose than in the placebo group (276 [220-331] vs 223 [188-259] s; p = 0.002). The groups did not differ significantly in time to moderate angina. In the ribose-treated group the changes from baseline to day 5 in both time to ST depression and time to moderate angina were significant (p less than 0.005), but these changes were not significant in the placebo group. In patients with CAD, administration of ribose by mouth for 3 days improved the heart's tolerance to ischaemia. The presumed effects on cardiac energy metabolism offer new possibilities for adjunctive medical treatment of myocardial ischaemia.
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PMID:Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. 135 76

In various clinical types of heart ischemic disease (stenocardia of stress and rest, large scale- and small scale myocardial infarction) alterations in activity of glycolysis and Krebs cycle enzymes as measured in leukocytes were especially distinct under conditions of large scale myocardial infarction as compared with the small scale infarction and stenocardia. Energy metabolism of leukocytes in heart ischemic disease was altered due to functional impairment of these cells, of the cellular immunity state as well as to the alteration in the activity of hydrolytic enzymes of leukocytes accumulating in the inflammatory infiltrate in myocardium. In the ischemic disease of heart the gas transport functions of erythrocytes were altered; the cells, exhibiting high resistance and elevated activity of the pentose-phosphate shunt, were found in circulation. The metabolic alterations in erythrocytes affected the rheological properties of blood. Estimation of enzymatic activity in blood cells is important for diagnosis of the heart ischemic disease of various types.
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PMID:[Metabolic changes in blood cells in various forms of ischemic heart disease]. 671 Sep 33