Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fatty acid composition and concentrations of serum phospholipids (PL) were examined in 14 normal subjects (NS), 10 patients with coronary heart disease (CHD) and stable angina pectoris, and in 12 patients with acute, fatal myocardial infarction (MI). The NS and patients with CHD and stable angina pectoris were matched with respect to age, height, body weight, blood pressure and serum cholesterol. Serum PL of patients with CHD and of patients with acute, fatal MI contained significantly more arachidonic acid (20:4n6, AA) than serum PL of the NS. Docosahexaenoic acid (22:6n3, DHA) was also increased in serum PL of patients with acute, fatal MI. AA and DHA levels in serum PL reflect changes in lipid metabolism that may relate to the cause and/or consequences of CHD.
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PMID:Arachidonic acid levels in serum phospholipids of patients with angina pectoris or fatal myocardial infarction. 405 May 52

Randomized controlled trials of marine omega-3 fatty acid supplementation in relation to coronary heart disease (CHD) have inconsistent outcomes, yet public health messages are uniformly positive. Originally, fish were seen as a low saturated fat protein source, and later as a valuable source of omega-3 fatty acids. Early trials indicated that increased fish oil consumption prevented restenosis after coronary angioplasty. Later trials demonstrated that fish oils prolonged life post myocardial infarction (MI). Currently, the potential antiarrhythmic effects of fish derived omega-3 fatty acids are seen as the primary reason for cardiac benefits, as suggested by one trial with compliant subjects with implantable cardioverter defibrillators (ICDs), and sudden death reduction in a post MI trial. However, the earlier benefits of EPA and DHA on restenosis have only been confirmed in a subgroup in a recent meta-analysis. Newer data indicate that fish oils may increase CHD events in men with angina. Furthermore, in two of three trials in patients with ICDs and a history of ventricular arrhythmias, fish oils showed no significant benefit or even increased the risk of appropriate ICD discharge. Certain groups of individuals may benefit from long-chain omega-3 fatty acids while others, including men with angina and some individuals with a history of ventricular arrhythmia, may not. Due to significant heterogeneity in the response to fish oils, further studies are required before making widespread recommendations for all groups to increase consumption of fish and fish oil.
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PMID:Heterogeneity in randomized controlled trials of long chain (fish) omega-3 fatty acids in restenosis, secondary prevention and ventricular arrhythmias. 1883 24