Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 68-year-old man who was treated for febrile angina with gentamicin, doxycycline, phenoxymethylpenicillin K, and minocycline developed a generalized pustular exanthema favoring the predilected areas (hands, feet). Apart from a subepidermal pustule, the most noteworthy histological finding was a pronounced leukocytoclastic vasculitis. After disappearance of the skin lesions an intradermal test using cilligen (penicilloyl-polylysin) was conducted. The test gave a strongly positive early reaction, and 48 h after this an acute pustular outbreak developed analogous to the original manifestation. Doxycycline tested late, produced no exacerbation even though it was positive in the intradermal test. This pustular allergical drug rash can be classified as a vasculitis leucocytoclastica allergica which, as we know, appears in various clinical forms. It does not form a new disease entity. Terms used so far, such as "pustular necrotizing angiitis", "generalized pustular drug rash", "acute generalized pustular bacterid", "pustulosis acuta generalisata", only partially correspond to the actual pathoetiology.
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PMID:[Leukocytoclastic vasculitis due to drug allergy presenting as generalized pustular exanthema]. 626 71

The therapeutic effect of statins on the stabilization of atherosclerotic plaques has been affirmed. In recent years, the inhibition of matrix metalloproteinases (MMPS) of tetracycline drug doxycycline has attracted more and more attention. In this paper, we observed the effect of atorvastatin and doxycycline on exercise tolerance in patients with stable angina pectoris. The results showed that there was no significant difference in the clinical efficacy of the two groups and the effect on the exercise tolerance (P<0.05). There were 4 cases of mild gastrointestinal reaction in the doxycycline group and no other serious adverse reactions. The total effective rate of treatment in the doxycycline group was 93.3%. Doxycycline treatment significantly reduced the frequency of angina pectoris and the incidence of cardiovascular events, and the treatment effect was better. To sum up, we think doxycycline is a safe, cheap, therapeutic drug to stabilize plaque.
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PMID:Effect of doxycycline and atorvastatin on improving exercise tolerance in patients with angina pectoris. 3020 71