Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Heart rate reduction is a well accepted and effective approach for the prevention of angina pectoris. Ivabradine is the first selective and specific inhibitor of the I(f) current and provides pure heart rate reduction without altering myocardial contractility. Clinical evidence of the antianginal and anti-ischaemic efficacy and tolerability of ivabradine comes from the largest clinical development programme that has ever been performed in stable angina pectoris, involving more than 5000 patients. Ivabradine at the dosages of 5 or 7.5mg twice daily is as effective as reference antianginal approaches such as beta-adrenoceptor antagonists and calcium channel antagonists. The clinical efficacy and safety of ivabradine has also been confirmed in a 1-year follow-up study. Ivabradine is well tolerated and free from the most commonly observed adverse effects of currently prescribed antianginal drugs. Visual symptoms can occur in a minority of patients treated with ivabradine and are not associated with structural ocular changes. The ongoing clinical development programme with the two major morbidity-mortality studies, BEAUTIFUL and SHIfT, has the potential to greatly extend the use of ivabradine in patients with coronary artery disease as well as in those with heart failure.
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PMID:Clinical results of I(f) current inhibition by ivabradine. 1799 62

Angina pectoris is a cardiac condition characterized by an insufficient perfusion to meet myocardial metabolic demand. A high heart rate represents an important factor in the induction of myocardial ischemia and subsequent angina. beta-blocker drugs are effective at reducing angina pectoris by decreasing the heart rate and are usually preferred as initial therapy in the absence of contraindication or intolerance. Ivabradine, a new oral drug for the symptomatic treatment of chronic stable angina pectoris, decreases the resting heart rate of patients with normal sinus rhythm. In many clinical trials, ivabradine has been directly compared with placebo, beta-blocker drugs (e.g., atenolol and propranolol) and calcium channel blockers (e.g., amlodipine). These studies have demonstrated ivabradine, given in doses of 5-10 mg twice daily, to be more effective than placebo for increasing time to angina onset and noninferior to atenolol 50-100 mg daily and amlodipine 10 mg daily for increasing total exercise duration in patients with chronic stable angina. Visual symptoms, a transient, enhanced brightness in a limited area of the visual field known as luminous phenomena or phosphenes, were the most common adverse effects in clinical trials. This article aims to provide a research update regarding this new drug, based on a literature search.
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PMID:Focus on ivabradine: a new heart rate-controlling drug. 1921 Feb 6