Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The acute effects of myocardial revascularization on overall left ventricular performance and on myocardial segmental wall motion were assessed intraoperatively in 22 patients who had unstable (11 patients) or stable angina pectoris (11 patients). Segmental contraction patterns were evaluated using an ultrasonic transit-time method. In 9 patients with unstable angina pectoris, notable improvement in segmental wall motion was observed as the short-term response to coronary bypass grafting. Hypokinetic patterns were rendered normal after revascularization. Despite marked changes in segmental myocardial function, overall left ventricular performance was not altered notably. In contrast, reperfusion did not lead to acute effects on either segmental wall motion or total left ventricular function in patients with stable angina pectoris. The results indicate that aortocoronary bypass grafting may improve segmental wall motion in patients with unstable angina.
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PMID:Acute effects of aortocoronary bypass surgery on left ventricular function and regional myocardial mechanics: a clinical study. 31 67

The correlation between persistent negative T wave on basal electrocardiogram and coronary anatomy or global and regional left ventricular function was investigated in 34 patients with unstable angina defined as new onset (< 2 months), crescendo or rest angina. The patients with history of previous myocardial infarction, pathological Q waves on electrocardiogram or documented elevation of CPK were excluded. Eighteen patients (group A) showed T wave inversion (> 1 mV) in at least two leads on the basal electrocardiogram, persisting for at least 48 hours before coronary arteriography. In 16 patients (group B) the basal electrocardiogram was normal. Left ventricular volumes and ejection fraction were calculated and the regional systolic wall motion was analyzed using the area method in the 30 degrees right anterior oblique view. Hypokinesis was defined as more than 2 standard deviation below the mean value calculated in 24 normal subjects. No difference was present for age (A: 61 +/- 9 vs B: 57 +/- 9 yrs) and sex distribution. Critical stenoses of at least one coronary artery was documented in all but one patient (in group B). The number of critical stenosis per patient was equal (1.8) in the two groups. Left main coronary artery showed narrowing > 50% in three patients of group A and in two patients of group B.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Persistent T-wave inversion in unstable angina: the correlation with the global and regional function of the left ventricle]. 142 10

Left ventricular cineangiograms (30 degrees right anterior oblique projection) and high fidelity left ventricular pressure were recorded at rest in 10 individuals with normal hearts and at rest and during an episode of angina provoked by rapid atrial pacing in 14 patients with obstructive coronary artery disease. Angiograms were digitised frame by frame. The ventricular perimeter was divided into 40 segments and regional ventricular function was examined by means of isometric and contour plots and by the construction of segmental pressure-wall displacement loops. In 10 patients 12 abnormal resting regions were identified. The commonest (11 regions) was delayed onset of inward endocardial motion during systole which was manifest by diagonal contour lines on the contour plot. Six regions (five with associated delay in onset of inward motion) showed resting hypokinesis. Angina was associated with the development of 19 new regions of abnormal wall motion in 12 patients. Fourteen of these regions of abnormality were thought to be primary events occurring as a consequence of ischaemia and five to be secondary events occurring in normally perfused regions of myocardium. Hypokinesis occurred in 12 regions, developing in a region with normal amplitude at rest in seven and as an extension of resting hypokinesis in five. In 10 out of 12 cases the region of hypokinesis developed in a region showing diagonal contour lines at rest. Asynchrony with delay in the timing of peak inward displacement relative to minimum volume occurred with angina in eight regions (in six cases concomitant with hypokinesis and in two cases in isolation). In contrast with hypokinesis the pattern of wall motion at rest did not permit regions developing asynchrony with angina to be identified. Pressure-displacement loops show that regional hypokinesis is associated with reduced segmental work and that regional asynchrony (delayed or premature timing of peak inward endocardial displacement) is associated with a loss of efficiency of energy transfer between the myocardium and the circulation. These observations illustrate the complex nature of wall motion abnormalities occurring with angina.
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PMID:Regional left ventricular wall motion in pacing induced angina. 335 22

Thallium-201 scintigraphy was performed in 20 normals and 60 patients (pts) with angiographically proven coronary artery disease (CAD) at rest after maximal exercise for evaluation of severity and location of CAD. The Tl-scintigrams were quantified by a Tl-score. The results of the Tl-score were compared with invasive and non-invasive parameters. Sensitivity asnd specificity of the Tl-score in evaluation of CAD was 90%. In normals, there were no significant differences from rest to exercise (Tl-score less than or equal to 1.2). Twenty-six of the pts with CAD, who had no evidence of myocardial infarction, showed a significant increase of Tl-score from 5.0 +/- 1.7 to 8.7 +/- 2.6 after exercise (p < 0.001). In 34 pts with CAD and a history of MI, Tl-score increased from 24.9 +/- 3.1 to 33.3 +/- 3.8 (p < 0.001). Exercised-induced ischemia was assessed by exercise electrocardiography in 48%, by Tl-score in 62% and by angina pectoris in 77%. In 37 pts, the Tl-score was compared with the coronary score, ejection fraction (EF) and local wall motion derived from biplane cineventriculograms. There was a significant correlation between the Tl-score and the EF: y = 79.13 - 1.11 x, n = 74, r = 0.688 (p < 0.001). No correlation was found between the coronary score and the Tl-score. Hypokinetic wall motion disturbances were assessed by Tl-score in 34% only, whereas akinesia and dyskinesia were detected in 86% (p < 0.001). The data suggest that Tl-scintigraphy even with a quantitative Tl-score is not sufficient for exact assessment of extent and severity of CAD.
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PMID:[Quantitative Tl-201 scintigraphy in diagnosis of severity and location of coronary artery disease. Comparison of a Tl-score to invasive and non-invasive parameters (author's transl)]. 744 54