Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The distribution of the interval of the heart beat of 93 test persons of the 4 groups normal group, group with labile essential hypertension, group with apparantly vegetatively conditioned heart pain and group with angina pectoris syndrome in coronary sclerosis may be described with the help of log normal distributions. In the vegetative group a dependence of the distribution parameters was proved. The results of a linear discriminance analysis for the vegetative group and the group with coronary sclerosis as well as the unequivocal age dependence of sigma at first do not allow a differentiation significant for practice according to the results got up to now. The different age structure might be regarded as cause in the two groups, so that further investigations are necessary.
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PMID:[Use of RR-interval distribution within the scope of ambulatory functional diagnosis in the angina pectoris syndrome]. 60 15

18 patients with uncomplicated angina pectoris were studied to ascertain the relative significance of individual hemodynamic factors in the production of angina pectoris. Each hemodynamic determinant of myocardial oxygen consumption (heart rate, systemic arterial pressure, LVEDP, and LV dp/dt max) were either altered or controlled as discretely as possible with the use of right atrial pacing, propranolol, phentolamine and ouabain, and the effects of these changes were observed on the onset and total duration of pain. Only heart rate correlated closely with the precipitation of angina. The systemic arterial pressure, LVEDP and LV dp/dt max did not correlate with the production and abolition of angina pectoris. The results indicate that drugs acting only against the effect of sympathetic stimulation of the sinus node would be a major advantage in the treatment of patients with angina pectoris. The unexpected finding that phentolamine did not ameliorate pain in patients with angina pectoris casts doubts as to whether nitroglycerine relieves anginal pain by lowering the systemic arterial pressure.
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PMID:Hemodynamic factors associated with the production of pain in angina pectoris. 62 18

After more than ten years of clinical application, direct myocardial revascularization with saphenous or mammary vein grafts is becomining one of the most common types of elective major surgery performed in the United States. The need for and the results of revascularization surgery are determined by cine coronary arteriography. The principles on which this type of surgery is based are simple. Critical occlusion of a coronary artery may produce an arteriographically identifiable area of myocardial perfusion deficit in the left ventricle. The functional demand for blood that results is usually manifested by anginal pain. When the occlusion is reduced by rest and administration of vasodilators, the immediate threat of infarction is alleviated. When pain persists in spite of treatment, direct revascularization surgery should be considered. This type of surgery need not involve ultrasophisticated adjuncts. Some of these adjuncts increase morbidity and contribute appreciably to the cost of operation and hospitalization. The record of myocardial revascularization suggests that the surgical treatment of coronary artery disease can and should be done in qualified community hospitals.
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PMID:Myocardial revascularization 1978. 62 32

Thallium-201 scintigraphy was performed during the pain free period in 98 patients with unstable angina. Scintiscans were positive in 39 patients, questionable in 27 patients and normal in 32 patients. Eighty-one patients responded favorably to treatment (group I). Seventeen patients had complicated courses (group II) and despite maximal treatment with propranolol either developed infarction (six patients) or continued to have angina necessitating coronary surgery (11 patients). In group I during the pain free period 26 of 81 patients had positive thallium-201 scans, whereas 20 patients had an abnormal ECG at that time; during angina 18 patients had transient ECG changes. In group II during the pain free period 13 of 17 patients had positive scans, whereas two patients had abnormal ECG at that time; during angina 12 patients showed transient ECG changes. The sensitivity to recognize group II was 76% for thallium-201 scintigraphy, 11% for ECG during the pain free period; 70% for ECG during angina; 94% for the combination of either positive scans or abnormal ECG. Thus, 1) positive thallium-201 scans occur in patients with unstable angina, 2) positive scans can be obtained during the pain free period, 3) thallium-201 scans are more frequently positive in patients with complicated course.
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PMID:Thallium-201 scintigraphy in unstable angina pectoris. 63 Jun 82

Seventy-five patients who had chest pain but no history or ECG evidence of myocardial infarction (MI) underwent myocardial-stress perfusion scintigraphy (MSPS) with thallium-201, treadmill-stress testing (TST), and coronary cineangiography (CA). The sensitivities of MSPS and TST for coronary stenosis greater than or equal to 75% were 68% and 71%, respectively; their specificities were 97% and 79%, respectively (0.1 greater than p greater than 0.05). When the character of a patient's chest pain is considered, Bayesian analysis leads to the following conclusions: (a) MSPS can be useful in pre-CA screening of patients with chest pain but no MI if their pain is thought to be of uncertain or nonischemic origin: (b) the sensitivity of Tl-201 MSPS is not sufficient for pre-CA screening of patients without MI who have typical or atypical angina pectoris; (c) the sensitivity of MSPS would have to be approximately 95% in order for the test to be useful in pre-CA screening of patients who have atypical angina pectoris; (d) MSPS may be superior to TST in these applications; and (e) it is not clear that there is any advantage in combining MSPS and TST into a single screening test rather than using MSPS alone.
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PMID:The predictive value of myocardial perfusion scintigraphy after stress in patients without previous myocardial infarction. 63 1

Three hundred and sixty-six patients (281 males and 85 females) were examined, 316 of them complained of pain the heart and retrosternal pain. Bicycle ergometry was conducted in all cases and the soft tissues of the neck, chest, and shoulder girdle were palpated carefully. In patients with angina pectoris tolerance to physical exertion was clearly diminished while palpation did not reveal, as a rule, disorders of sensibility in the soft tissues of the chest and shoulder girdle. Patients with pain in the heart of a neurotic character tolerated physical exertion fairly well and often had increased sensibility of the soft tissues in the left side of the chest and shoulder girdle. The intensity of cardialgia may be judged objectively by the degree of soft tissue tenderness and its spread.
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PMID:[Differential diagnosis of cardialgia]. 63 15

When a patient's coronary arteries are anatomically normal, variant angina probably results from transient spasm that narrows and occludes a coronary artery; medical treatment is usually advised. But this distinctive type of pain can also occur in conjunction with atherosclerotic disease, in which case bypass surgery may prove highly effective in relieving symptoms and averting the risk of myocardial infarction.
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PMID:Management of variant angina and coronary spasm. 64 Jun 33

Fourteen patients suffering from abdominal angina have been operated on with different revascularization techniques. Preoperatively all of them had classical symptoms: postprandial pain and all except two had remarkable weight loss. There were six patients with isolated coeliac axis stenosis and in eight cases there were two or three diseased vessels. Liberation and reconstruction of the coeliac axis were carried out in six cases. Aorto-hepatic by pass graft was performed in three patients. Reinsertion of SMA was done in four and reinsertion of IMA in one case. Reconstruction of SMA with a by pass graft was carried out also in one case. There was no operative mortality. One of the patients died five weeks postoperatively at home from myocardial infarction. Another patient operated on in 1965 died seven years later at the age of 78 from myocardial infarction. He had had no further symptoms of abdominal angina postoperatively. The remaining 12 patients were relieved of their symptoms after the operation. They have been followed up for a mean of 5.5 years. The good long term results of arterial reconstructions in contrast to the poor prognosis without operation, favours early operation. The importance of early diagnosis and the importance of early operative treatment are emphasized.
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PMID:Clinical experience with surgical treatment of chronic intestinal ischaemia. 67 76

Four patients underwent exercise testing because of a history of pain in the chest; all four developed marked elevation of the S-T segment only during recovery after exercise. Three of the four patients showed ST-segment depression during exercise, but ST-segment elevation was absent until two or more minutes after cessation of exercise. ST-segment elevation after exercise was accompanied by hypotension in three patients and by ventricular arrhythmias in one. Subsequent coronary angiographic studies revealed normal or minimally diseased coronary arteries in two patients and significant coronary lesions in the other two. Review of the literature shows that contrary to the prevailing belief, over half of the patients with Prinzmetal's variant angina have electrocardiographic changes diagnostic of ischemia during exercise testing. Over half of the patients with abnormal findings on tests during exercise display ST-segment elevation as a manifestation of ischemia; however, delayed ST-segment elevation of the type seen in these four patients is distinctly uncommon, having previously been described in only three individual case reports. The pathophysiology of this response is uncertain but may relate to rapid alterations in the autonomic balance during recovery after exercise.
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PMID:ST-segment elevation during recovery from exercise. A new manifestation of Prinzmetal's variant angina. 67 40

In 44 consecutive patients with angina at rest associated with transient S-T segment elevation, clinical features were correlated with angiographic coronary anatomy. Patients were divided into three groups depending on the number of major vessels having greater than or equal to 70 per cent luminal narrowing: Group I = no or minimal disease (six patients); group II = single vessel disease (13 patients); and group III = multiple vessel disease (25 patients). The following features did not differ significantly among groups I, II or III: age, sex, risk factors, time from onset of episodes of pain at rest to study or arrhythmias during ischemic episodes. Patients in group III were more likely to have angina on effort (p less than 0.001) and an abnormal base line electrocardiogram (p less than 0.001) than patients in groups I or II. However, the absence of these features did not separate patients in group I from those in group II. In patients with angina at rest associated with transient S-T segment elevation, clinical features identify patients with multiple vessel disease but do not allow differentiation of patients with no or minimal coronary disease from patients with single vessel disease.
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PMID:Rest angina with transient S-T segment elevation. Correlation of clinical features with coronary anatomy. 68 11


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