Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-one reoperations for relief of angina have been performed at Stanford Medical Center in patients who had had previously unsuccessful direct coronary artery surgery. Complete releif of angina was obtained in seven (33%), improvement of angina in six (29%), and no change in angina in eight (38%) after these operations. Reoperation was least successful in relieving angina when performed in patients with graft occlusion and most successful when performed in patients with new critical lesions or with previously unbypassed critical lesions (P less than 0.02). Reoperation was of greater benefit in patients with unstable angina than in those with stable angina (P less than 0.05). Four of the seven patients having no angina after reoperation sustained perioperative infarctions. Reoperation does not provide the same rate of angina relief as first operations; however, certain subgroups of patients may exhibit more favorable results.
 ...
PMID:Results of reoperation for unsuccessful coronary artery bypass surgery. 4 20

Four patients with homozygous hyperbetalipoproteinaemia who had proved resistant to intensive medical therapy have undergone portacaval shunt. During 3 weeks of total parenteral alimentation before the operation, the serum-cholesterol decreased significantly in each of the four patients. During the fat-emulsion phase of hyperalimentation, one patient experienced a rise in cholesterol. Postoperatively, the size of xanthomas decreased in all cases; serum-cholesterol levels rose above those achieved during hyperalimentation, and this rise continued for as long as 3 months before a further reduction was recorded. In patients with angina, this improved considerably; and in most cases bruits decreased in itensity. The results at this stage do not, however, suggest portacaval shunt for all patients with homozygous hypercholesterolaemia.
 ...
PMID:Portacaval shunt in four patients with homozygous hypercholesterolaemia. 4 58

Two young women with homozygous familial hypercholesterolaemia and coronary and aortic atheroma were treated by repeated plasma exchange, using a continuous-flow blood-cell separator, for 4 and 8 months. A pronounced reduction in plasma cholesterol and low-density lipoprotein (L.D.L.) concentrations was achieved by exchanging each patient's plasma with cholesterol-free plasma protein fraction (B.P.), at 3-weekly intervals on an outpatient basis. By pre-labelling the patients' cholesterol with 14-C and comparing the specific activity of the cholesterol in adipose tissue with that in plasma, evidence was obtained of an influx of tissue cholesterol into plasma after each exchange. There was no side-effects and both patients lost their angina. Plasma exchange offers a new and practical approach to the long-term management of this lethal disorder and may also provide information about the possible reversibility of human atheroma.
 ...
PMID:Plasma exchange in the management of homozygous familial hypercholesterolaemia. 4 33

In order to study the occurrence and frequency of ischemia-induced ventricular arrhythmias, we analyzed 105 episodes of spontaneous angina pectoris occurring at rest in 28 hospitalized patients with unstable angina pectoris and proved coronary artery disease. Of 24 patients with serious ventricular arrhythmias during pain, 17 (57%) were arrhythmia-free during monitoring. In the other four patients, 17 of 29 (59%) pain episodes were associated with serious ventricular arrhythmias, and three of these four had serious ventricular arrhythmias during pain-free periods. Each patient tended to manifest the same type of arrhythmia during repeat episodes of pain. It appears that continuous electrocardiogram (ECG) monitoring is important during the initial hospitalization of the patient with unstable angina. The presence of ventricular arrhythmias during pain-free periods indicates a high risk for serious ventricular arrhythmias during episodes of spontaneous pain. These patients should be considered for continued ECG monitoring and antiarrhythmic therapy.
 ...
PMID:Ventricular arrhythmias during unstable angina pectoris. 5 51

In patients with coronary atherosclerosis in I and III stages content of histamine in blood, excretion of free histamine with urine, activities of serum histidine decarboxylase and diaminooxidase, histaminopexy of blood serum and content of antihistamine factor were studied. In patients with the disease of the I stage during the attacks of stenocardia content of histamine in blood, the activity of diaminooxidase and content of degranulated basophils were increased, but the histidine decarboxylase activity, histaminopexy, content of antihistamine factor and excretion of free histamine with urine were normal. During the stenocardia attacks in patients with coronary atherosclerosis of the III stage content of degranulated basophils, the histidine decarboxylase activity were increased, histaminopexy and titres of antihistamine factor were decreased. Between the content of histamine in blood and the diaminooxidase activity no correlation was observed. This lack of correlation could cause development of hyperhistaminaemia and increased excretion of free histamine with urine. Antihistamine and desensitizing preparations (pipolphen, heparin, amidopyrine and ascorbic acid) increased the therapeutic efficiency of vasodilating drugs, decreased stenocardia attacks, accelerated both clinical improvement and normalization of histamine metabolism.
 ...
PMID:[Metabolism of histamine in patients with coronary atherosclerosis]. 5 86

Serum antithrombin activity (AA) was correlated with coronary angiographic findings in 69 patients with documented angina. There was excellent correlation between normal values and normal coronary circulation or only one-vessel stenosis in 30 of 35 patients (86%). When AA was above 90%, 90% of patients (20 of 22) had normal circulation or one-vessel occlusion. In 24 patients AA values were significantly decreased. Coronary angiography in this group revealed three with normal circulation or only one-vessel involvement (10%); 21 of 24 had two or three vessels occluded (90%). The correlation between severe CAD and low AA is probably coincidental to a "triggered" or "turned-on" clotting system. The most practical clinical contribution of AA estimation relates to this capacity to identify angina patients in whom clot-preventive measures (aspirin; dipyridamole; anticoagulants) might prove beneficial.
 ...
PMID:Serum antithrombin in coronary-artery disease. 5 72

During administration of bishydroxycoumarin, hematocrit, viscosity of whole blood, and viscosity of plasma decreased in samples from nine healthy volunteers and 31 patients who had coronary heart disease. The relationships between viscosity of blood and intensity of anticoagulant therapy varied from patient to patient. Discontinuation of the drug was followed by return of viscosities to pretreatment levels in two to four days. The decrease of viscosity of blood by anticoagulant therapy may explain the relief of anginal pain in patients who have coronary heart disease.
 ...
PMID:Blood viscosity and oral anticoagulant therapy. 5 87

The clinical findings in 45 patients with angina and normal coronary arteries are reviewed. The primary site, radiation, and character of the pain were typical of angina but the pain was atypical in its relation to stress, frequency of occurrence, relief with rest, and response to nitroglycerin. 22 had abnormal electrocardiograms with evidence of past myocardial infarction in 3. 5 had abnormal exercise tests. During a two-year follow up period there were no further myocardial infarctions and anginal pain either disappeared or improved in 73%. It is concluded that patients with angina and normal coronary arteries can often be distinguished clinically and that they have a good prognosis.
 ...
PMID:Clinical features and follow-up of patients with angina and normal coronary arteries. 6 May 68

Mortality follow-up is now complete for 5 years in the 18 403 male civil servants aged 40-64 who were examined between 1967-69 in the Whitehall Study of British civil servants. During this period, 277 of them died of coronary heart-disease (C.H.D.); half of these deaths were in subjects in whom the findings at initial screening had suggested early myocardial ischaemia (angina or history of possible infarction according to standard questionnaire, or electrocardiographic evidence of ischaemia). The finding of suspect ischaemia had greater predictive power than the "primary" coronary risk factors, from which it was generally independent. At each level of the primary risk factors, the risk of death from C.H.D. was much greater in the presence of suspect ischaemia; and, with the possible exceptions of glucose tolerance and physical activity, the main risk factors still operated even at the stage of early ischaemia. These findings have implications for future studies of the effects of intervention.
 ...
PMID:Myocardial ischaemia, risk factors and death from coronary heart-disease. 6 47

Blood-carboxyhaemoglobin (COHb) levels were studied in 343 healthy male cigarette smokers aged 35-64. The mean COHb level was 30% higher in the 248 men who smoked unventilated filter cigarettes than in the 41 men who smoked plain cigarettes, after adjusting for the number of cigarettes smoked (P less than 0.001). This result was consistent with the carbon-monoxide (CO) yields of these cigarettes: on average, the unventilated filter cigarettes had yields 25% higher than the plain ones. The mean COHb level was 7% higher in the 54 men who smoked ventilated cigarettes than in men who smoked plain cigarettes. Although this difference was not statistically significant, it was in the opposite direction to the result which might have been expected on the basis of the CO yields of these cigarettes: on average the ventilated filter cigarettes had yields 21% lower than the plain ones. The medical implications of these results are uncertain. COHb levels of 3-4% or more can exacerbate angina pectoris and intermittent claudication, and it is, therefore, of concern that COHb levels are higher in smokers of filter cigarettes than in smokers of plain cigarettes. However, any assessment of risk associated with either type of cigarette should take account of the observation from other studies that filter cigarettes are associated with a lower mortality from lung cancer than are plain cigarettes.
 ...
PMID:Carboxyhaemoglobin levels in smokers of filter and plain cigarettes. 6 48


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>