Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The tolerability of epanolol, a new antianginal agent given as a single daily oral dose of 200mg, has been compared with the oral formulation of metoprolol (100mg twice daily) in a multicentre, randomised, double-blind, crossover study in 573 patients with stable angina (VISA 1). Patient preference for treatment was determined and efficacy was also monitored. Four weeks' treatment with one agent was followed by 4 weeks' treatment with the alternative agent. At the end of the study, patients were asked to express a preference, where possible, for 1 of the 2 treatments. The preliminary results of the study show that the preference question was answered by 524 patients (91.9%), and although 30 more patients preferred epanolol (45% preferred metoprolol, 55% preferred epanolol), the trend did not reach statistical significance (p = 0.137). Reasons for preference for epanolol were largely based on patients having fewer adverse effects, with fewer angina attacks and a general improvement in well-being as secondary reasons. Reasons for preference for metoprolol, however, were evenly divided between fewer adverse effects and fewer angina attacks, with a general improvement in well-being of less importance. Responses to a tolerability questionnaire consisting of 43 questions on 7 different body systems showed that epanolol had a significantly better profile than metoprolol for 10 of the side effects, particularly those associated with beta-blocker treatment. Responses to only one question indicated that patients tolerated metoprolol better than epanolol. Two patients died during the study (one on metoprolol treatment and one on epanolol treatment). Neither death was attributed to the study treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Comparative multicentre study of the tolerability and efficacy of epanolol versus metoprolol in patients with stable angina pectoris. 257 82

The primary aim of this multicentre, randomised, double-blind, crossover study in 529 patients with stable angina pectoris was to compare the tolerability of epanolol, a novel antianginal agent, administered as a single oral daily dose of 200mg, with an oral retard formulation of twice-daily nifedipine 20mg and to determine patient preference (VISA 2). Confirmation of equal efficacy and safety monitoring were secondary aims of the study. Treatment consisted of 4 weeks on each therapy, and at the end of the study each patient was asked to state their treatment preference. 448 patients (85%) answered the preference question. Preliminary analysis of the data showed that 61% of patients preferred epanolol vs 31% who preferred nifedipine (p less than 0.001). Reason for a preference for epanolol were mainly fewer adverse experiences (11% vs. 23% with nifedipine), a general improvement in well-being (16% vs 10% with nifedipine) and a decrease in the number of angina attacks (11% vs 10% with nifedipine). A tolerability questionnaire comprising 43 questions and covering 7 different body systems showed that epanolol had a better profile than nifedipine for the following 7 side effects: poor sleep, abdominal pain, flushing, swollen ankles, palpitations, headache and a general feeling of being unwell. Four patients died during the study; none of the deaths were associated with the study treatment. Treatment with nifedipine resulted in 63 patient withdrawals compared with 31 patient withdrawals during epanolol treatment; there were 5 patient withdrawals from both treatments. The main reasons for withdrawal of patients from nifedipine treatment were adverse events (9% vs 4% with epanolol) and a lack of efficacy (3% vs 2% with epanolol).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Comparative multicentre study of the tolerability and efficacy of epanolol versus nifedipine in patients with stable angina pectoris. 257 83

The concept of quality of life is used to determine clinically relevant aspects of subjective symptoms and well-being, and refined psychometric instruments are now being developed to assess changes in well-being during pharmacological therapy. In order to evaluate general well-being, subjective symptoms and common side effects during cardiovascular therapy, workers at this hospital have designed a quality of life questionnaire. This consists of a generic section for the evaluation of 3 global aspects of well-being (hedonic tone, activity and relaxation) and a specific symptoms section for assessing 21 common side effects of cardiovascular drugs. The test is based on visual analogue scales. This questionnaire was used in a Swedish subsample (n = 211) of the epanolol versus metoprolol study in patients with stable angina pectoris (VISA 1). In this double-blind crossover study, there were no significant differences between epanolol and metoprolol as regards general well-being with this sample size. The frequency of some specific symptoms (fatigue, sleep disturbances, vivid dreams and cold digits) was somewhat lower during epanolol treatment, but the differences did not attain statistical significance.
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PMID:The effects of epanolol on quality of life. 257 87