Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An indirect ELISA method has been used to study formation of autoantibodies (AA) to myocardial myofibrillar proteins in patients with different clinical IHD forms. Purified myosin (MS), actin (AC) and tropomyosin (TM) of the intact human myocardium acted as antigens. The highest level of AA to MS and AC was found in patients with AMI (acute myocardial infarct): it exceeded twice that of the norm and 1.5 times that in patients with IAP (instable angina pectoris). Moreover the AA level in IAP patients exceeded that of normal 1.5 times. In PC (postinfactional cardiosclerosis) patients the MS AA and AC AA tend to the norm. The TM AA contents in PC patients is 1.2 times higher than that in AMI and IAP patients, not differing from the norm in all patient groups. The role of autosensibilization to contrectile proteins in progress of IHD and development of AMI is discussed.
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PMID:[Autosensitization to myofibrillar proteins of myocardium in patients with different clinical forms of ischemic heart disease]. 775 96

While studying the functional activity of poly- and mononuclear leucocytes in 75 patients with various clinical types of ischemic heart disease (angina of effort, angina decubitus, arrhythmias, cardiac insufficiency at the background of atherosclerotic cardiosclerosis and atherosclerotic hypertension), decline in the functional activity of the phagocytizing cells has been revealed, this being considered to be a pathogenetic prerequisite for atherosclerosis progression.
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PMID:[The functional activity of the poly- and mononuclear leukocytes in patients with different clinical forms of ischemic heart disease]. 783 69

We have compared the use of primary health care and the diagnoses at visits to doctors in the Spili Health Centre (SHC) in Crete and the Dalby Health Centre (DHC) in Sweden. In DHC more patients per 1000 population visited the doctors than in SHC. This was so regardless of age-group and sex, in fact more or less regardless of diagnosis. Other differences between the populations were: The diagnosis acute otitis media was more frequent in the Dalby children than in the Spili ones. The opposite was true of "head injuries" which were more frequent in the Spili boys. Visits to doctors for bronchitis was more frequent in the Spili men, maybe because of the extensive smoking habits of Cretan men. Visits for diseases of the musculoskeletal system were more frequent in DHC than in SHC. A hypothesis worth testing is that this was influenced by differences in the health insurance and sick benefit systems. Angina pectoris was fairly frequent in both areas but cardiosclerosis (including healed myocardial infarction) was more common in DHC than in SHC. Use of primary health care may be influenced by the need for health care in the population, the accessibility of the health care facilities, the costs for the patients, the quality of care as perceived by the patients and by other sociocultural factors. Comparative studies, even though fairly uncommon today, may be of use in generating hypotheses about the impact of different factors on the use of health care.
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PMID:Differences in the diagnose panorama in primary health care in Dalby, Sweden and Spili, Crete. 846 44

Measured in 119 patients with chronic heart disease (exercise-induced angina in 62, cardiosclerosis in 57 cases) presenting with arrhythmias (extrasystolic arrhythmia, permanent form cardiac fibrillation, association of cardiac fibrillation with ventricular arrhythmia, with n = 58, 38, 23 respectively) were blood levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxin (T4) using immunoradiometric assay. In extrasystolic arrhythmia, permanent form cardiac fibrillation, there were no deviations from the norm in the basal TSH blood levels, reduction in (T3) as well as augmentation of (T4) in cardiac fibrillation. With permanent form cardiac fibrillation associated with ventricular arrhythmia the TSH blood level got decreased, the (T3) and (T4) content undergoing no changes The posttreatment blood content of (T3) tended to augment in extrasystolic arrhythmia.
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PMID:[The function of the thyroid and thyrotropic function in patients with chronic ischemic heart disease and rhythm disorders]. 962 22

A total of 124 patients with ischemic heart disease (IHD) were studied. Of these, 53 presented with painless IHD form, 28 patients had atypical pain syndrome. It has been shown that the threshold exercise level both in those persons free from angina pectoris but with postinfarction cardiosclerosis and those with no history of myocardial infarction is not significantly different from and is appreciably higher than in IHD patients with angina pectoris and episodes of "silent ischemia". Informative value has been studied of other diagnostic tests in the above patients: stress-test appeared to be positive in 42.8% of patients, cold test--in 6.3%, hyperventilation test in 16.8% of patients. Painless myocardial infarction (PMI) was detected in 50% of patients with postinfarction cardiosclerosis and 63.6% with no history of myocardial infarction, as evidenced by 24-h ECG monitoring. Analysis of angiogrammes in those persons with atypical pain syndrome showed hemodynamically significant injury to the coronary vessels in 57.1% of patients and a spasm of coronary vessels in 33.3%. PMI occurs in patients with different IHD forms including those with prior MI free from stenocardia.
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PMID:[The functional characteristics of patients with the silent form of ischemic heart disease]. 962 38

Contrast baths effects on hemostasis were studied in 72 patients with postinfarction cardiosclerosis and stable angina pectoris. Hemostasis was assessed by recalcification time, blood plasma tolerance to heparin, fibrinolytic activity, functional activity of antithrombin, soluble fibrin-monomeric complex, platelet count and aggregation. The results were compared to those in patients exposed to laser irradiation. Hydrotherapy with contrast baths was hemostatically effective in 70.9% of patients. Blood coagulation and platelet aggregation improved, the risk of intravascular microthrombogenesis diminished. Contrast baths had more pronounced beneficial effects on coagulation in ischemic heart disease of NYHA functional class II.
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PMID:[The effect of contrast baths on the hemostatic function of patients with ischemic heart disease]. 977 Nov 41

Four hundred and nineteen elderly and old patients with pulmonary tuberculosis were examined. One hundred and ninety six patients were found to have an active tuberculous process and contaminant diseases: essential hypertension in 20.7%, functional classes II-III angina pectoris in 55.6%, postinfarct cardiosclerosis in 23.7%. Hypertrophy of the right cardiac cavities was frequently accompanied with that of the left ones (38.1%). Respiratory diseases caused by comorbidity were prevalent among acid-alkali balance disorders. Metabolic disturbances were detected in 90 (21%) patients. Evaluation of pulmonary and cardiac functions by the analysis of acid-alkali balance, gases, blood, and ECG in geriatric patients allows pathogenetic therapy to be timely and soundly.
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PMID:[Pulmonary and cardiac functions in patients with pulmonary tuberculosis]. 1075 Apr 25

50 patients with postinfarction cardiosclerosis and angina pectoris (functional class I-IV) having left ventricular ejection fraction < 45% entered a comparative cross-over trial of antianginal effectiveness of anaprilin and carvediolol (dilatrend). In 10 patients carvedilol was compared to placebo. Carvedilol is shown to demonstrate higher antianginal activity which is the highest in patients with angina pectoris of low load. The analysis of peripheral vascular resistance and double product attributes antianginal advantages of carvedilol to its more potent effect on cardiac performance due to peripheral vasodilatation.
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PMID:[Clinical and hemodynamic effects of anaprilin and carvedilol in patients with coronary heart disease]. 1184 Aug 2

Patients with postinfarction cardiosclerosis in association with angina (NYHA class III) during coronary artery bypass grafting usually develop oxidative stress in erythrocytes which is characterized by enhanced free radical oxidation and depression of antioxidative enzymes. This process is of especially great importance and lasts longer in patients with the reperfusion syndrome. The consequences of this process could be revealed as derangement of the functional and structural state of erythrocytes, "rheological crises", further depression of the postischemic myocardium, rhythm and coronary flow disturbances. The results obtained show the effective prophylactics and antioxidant treatment of the oxidative stress syndrome to be necessary.
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PMID:[Features of forming oxidative stress in blood of postinfarct cardiosclerosis patients during aortocoronary bypass]. 1204 80

The authors compare distribution of genotype frequencies and alleles of I/D of ACE gene polymorphism in patients with various forms of ischemic heart disease (IHD): with acute myocardial infarction (MI), stable effort angina (functional class II-III); in patients with postinfarction cardiosclerosis (PICS). A relationship was found between I/D polymorphism and acute MI. Frequency of DD genotype in MI patients was 0.57, in controls--0.21, p < 0.0001, RR = 4.9. The DD genotype may serve a marker of hereditary predisposition to MI. Genotype DD frequency in the group with acute MI was higher than that with PICS. In acute MI frequency of allele D was 0.76, in PICS--0.51, p < 0.0005. It is suggested that low frequency of genotype DD in the PICS group results from higher lethality of patients with DD genotype in the nearest rehabilitation period. Patients with repeated MI have a significantly higher frequency of genotype DD and complications after MI. Thus, there is a relationship between insertion-deletion polymorphism of ACE gene and myocardial infarction. Deletion DD genotype raises the risk to develop MI and probability of life-threatening complications and repeated MI.
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PMID:[ACE gene I/D-polymorphism and hereditary predisposition to myocardial infarction]. 1236 Jun 13


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