Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Holter monitoring, echocardiography and 201Tl myocardial scintigraphy were performed in 40 patients with postinfarction cardiosclerosis. The monitoring revealed silent myocardial ischemia (SMI), including 27 having SMI with concurrent anginal episodes, 7 with SMI alone. A direct correlation was found between the duration of SMI and silent myocardial infarction (r = 0.539; p less than 0.05). The patients with left ventricular failure and myocardial hypertrophy exhibited longer SMI, as evidenced by echocardiography. 201Tl myocardial scintigraphy revealed no relationship between the degree of SMI and the dimensions of a postinfarction scar. SMI was detected in 77.5% of the patients with postinfarction cardiosclerosis. The duration of SMI was longer with the presence of angina pectoris, left ventricular failure or myocardial hypertrophy.
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PMID:[Painless myocardial ischemia in patients with post-infarction cardiosclerosis]. 153 93

As many as 64 patients with coronary heart disease (CHD) were examined. They were divided into 3 groups: (1) control subjects; (2) patients on supplementary rheogluman and (3) those on supplementary haemodesum (neocompensan). Their status was assessed from the frequency and intensity of anginal attacks, the magnitude of changes in lipid metabolic parameters prior to and following the therapy. Rheogluman and haemodesum were ascertained to have a favourable effect on the course of CHD, rheogluman producing a more beneficial effect. Supplementation of rheogluman to the treatment of CHD resulted in better correction of lipid metabolic disturbances in postinfarction cardiosclerosis to a greater extent than in angina. The hypolipidemic effect of haemodesum was slightly weaker than that of rheogluman. Rheogluman contributes to better correction of lipid parameters mainly in Type IIb hyperlipidemia, whereas haemodesum is more effective in type IIa.
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PMID:[Effect of lymph-stimulating drugs on the clinical manifestations and parameters of lipid metabolism in patients with post-infarction cardiosclerosis and angina pectoris]. 172 93

Multifactor discriminant analysis was used on a computer to examine 100 patients with myocardial infarction in the subacute period (at week 4 of the disease onset) and 76 in the postinfarction period (at months 2-120 of postinfarction). A complex of clinical and coronary signs was defined, which differentiated patients with subacute myocardial infarction and postinfarct cardiosclerosis, as well as those with postinfarct stable and progressive angina pectoris.
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PMID:[Clinical manifestations of ischemic heart disease in the subacute period of myocardial infarction and post-infarct cardiosclerosis depending on the status of coronary arteries]. 180 61

The results of the catamnestic study of case reports and records of postmortem examination of 102 patients with bronchial asthma (BA) aged 47 to 88 years who died at a general hospital during 1976-1988 indicate that in the overwhelming majority of cases, there took place death "with asthma" rather than death "from asthma". At the same time the dominant pathology was coronary heart disease (acute coronary failure, myocardial infarction, progressive heart failure associated with atherosclerotic and postinfarction cardiosclerosis). Emphasis is laid on the fact that according to the autopsy data, the rate of the recognized stenosing atherosclerosis of the coronary arteries considerably exceeded the number of cases of coronary heart disease documented clinically (typical angina pectoris of effort, significant macrofocal myocardial infarction). The characteristic features of the group under observation included an unexpectedly frequent combination of BA and malignant neoplasms (24 cases), including lung cancer in 13 of these cases.
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PMID:[An analysis of the causes of death in bronchial asthma patients (based on the data from a 13-year prospective observation)]. 236 7

The results of the maximal rate of heart ventricle activation (HVA) determined according to the ECG readings and its first derivative were compared in 38 patients suffering from coronary disease (CD) with the coronarography data. 54 healthy men without the clinical and bicycle ergometry signs of CD were examined as control. In patients with angina pectoris, postinfarction cardiosclerosis and acute myocardial infarction, there was a significant decrease of HVA. As the rate of the degree of coronary artery stenosis increased, there was a progressive reduction of the rate of HVA.
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PMID:[Diagnostic potential of the first ECG derivative in assessing the coronary artery status of patients with ischemic heart disease]. 239 65

The levels of lipid fractions, free and bound fatty acids, initial and end lipid peroxidation products in the blood plasma, red cell membrane resistance to hemolysis, and myocardial contractility before, during, and after therapy with lipostabil forte (0.6-1.8 g daily or 10 ml (0.5 g) i.v.) and bezafibrate (0.2 g 3 times daily) along with nitrates (10 to 30 tablets) have been examined by the routine methods in 159 patients with stable angina pectoris and postinfarction cardiosclerosis. A negative effect of high doses of nitrates on myocardial hemodynamics and fatty acid composition has been revealed, resulting in accumulation of bound fatty acids. Lipostabil has improved the patients' status, myocardial function, and lipid composition, reduced the levels of atherogenic lipids and lipid peroxidation products, as well as the concentration of fatty acids with an uneven number of C atoms, increased the fatty acid nonsaturation index and the level of medium-strand fatty acids. Improvement of the patient's condition in bezafibrate therapy has been less evident; the concentration of atherogenic lipids has been reduced, but the levels of bound fatty acids and of lipid peroxidation products has increased. Bezafibrate is recommended to be administered together with antioxidants.
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PMID:[Disorders of fatty acid composition and the processes of lipid peroxidation in chronic ischemic heart disease]. 276 20

Predictive value of myocardial 99mTc-pyrophosphate scintigraphy was assessed in 122 patients with postinfarction cardiosclerosis. In those cases where clinical and scintigraphic complication risk estimates considered, further evidence was shown to be redundant. Prognosis in patients with positive scintigraphic results and asymptomatic postinfarction cardiosclerosis or first-to-second class stable angina should take into account the size of myocardial pyrophosphate accumulation focus and the pattern of stress-induced changes in blood supply of the sites of myocardial damage. Negative scintigraphic results have no predictive value in those postinfarction cardiosclerosis patients who show clinical signs of heart failure and/or severe coronary insufficiency at the time of investigation.
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PMID:[Prognosis of the clinical course of post-infarction cardiosclerosis on the basis of pyrophosphate-labeled myocardial scintigraphy]. 285 Mar 93

Myocardial pyrophosphate accumulation was examined in various forms of coronary heart disease. The status of the coronary reserve in the myocardial lesion foci where pyrophosphate is accumulated has been shown to determine the severity of coronary failure in various uncomplicated forms of the disease, such as angina without prior myocardial infarction, myocardial infarction in the early phase of its healing, and postinfarction cardiosclerosis. In postinfarction cardiosclerosis, the dimensions of such foci are significant in the development of clinical events of coronary failure.
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PMID:[A non-invasive method of determining the severity of coronary insufficiency in various forms of ischemic heart disease]. 285 76

Combined assessment of some parameters related to hemostasis and blood plasminogen-plasmin and kinin systems and their inhibitors was carried out in 150 patients with stable angina and postinfarction cardiosclerosis during rationed exercise (bicycle ergometry). Patients with low stress tolerance showed considerably activated kallikrein-kinin system, depressed total fibrinolytic activity, elevated trypsin and enhanced platelet adhesive properties, while their inhibitor activities were reduced. Postmyocardial infarction patients showed a more dramatic increase in free kinins, coupled with depressed inhibitor proteinases and kininase activities, and a slight increment in fibrinolytic activity, as compared to patients having to history of myocardial infarction. The magnitude of free kinins and trypsin rise and kininase fall increases with age in these patients.
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PMID:[Various indicators of hemostasis, plasminogen-plasmin and kinin systems of the blood and their inhibitors in patients with stable angina pectoris and post-infarction cardiosclerosis after graded physical load]. 295 50

A study of the relationship between the frequency of labelled pyrophosphate detection in the heart muscle and the incidence of clinical signs of heart failure or angina in 185 postmyocardial-infarction patients demonstrated that the distribution of patients with postinfarction cardiosclerosis among the positive and negative 99mTc-pyrophosphate scintigraphy groups was governed by the presence of heart failure in these patients, a finding suggestive of the scarry fields within the myocardium as the principal cause of myocardial accumulation of labelled pyrophosphate in postinfarction cardiosclerosis. Pyrophosphate accumulation in patients with postinfarction cardiosclerosis can be regarded as an indicator of unfavorable developments, as confirmed by one-year follow-up results in 114 patients.
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PMID:[Accumulation of pyrophosphate in the myocardium in post-infarction cardiosclerosis]. 300 38


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