Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The blood plasma gamma-glutamyltranspeptidase (GGTP) activity was studied in 133 patients with macrofocal myocardial infarction, in 40 patients with microfocal myocardial infarction, in 30 patients with angina pectoris, and in 75 patients with cardiosclerosis and congestive cardiac failure. The activity of the enzyme increased in most patients with macrofocal myocardial infarction and in less than half of those with microfocal myocardial infarction beginning with the 3rd or 4th day, reached maximum by the 6th to 8th day of the disease, and then returned to normal levels in various lengths of time. In all patients with angina pectoris and acute left-ventricular failure the activity of the enzyme remained normal. It may be assumed from the results of the study that determination of GGTP activity in dynamics may be mainly employed in the diagnosis of macrofocal myocardial infarction, particularly after the first days of the disease. The enzyme test is hardly suitable for differential diagnosis between microfocal myocardial infarction and angina pectoris.
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PMID:[Gamma-glutamyl transpeptidase activity in ischemic heart disease]. 2 82

Seventy-seven patients with chronic ischemic heart disease were treated in single-seater oxygen hyperbaric chambers; 52 patients had angina pectoris of effort or angina of effort and at rest while 25 patients with macrofocal postinfarction cardiosclerosis had insufficiency of pulmonary or systemic circulation. Treatment consisted of 12--15 procedures. The use of hyperbaric oxygenation in a complex with drug therapy makes it possible to alleviate or arrest the attack of angina pectoris and relieve considerably the symptoms of cardiac decompensation. The initial condition of central hemodynamics affects greatly the results of barotherapy. Normal parameters of hemodynamics hardly change after treatment. At the same time, in patients with markedly reduced myocardial contractility hyperbaric oxygenation causes evident positive changes in hemodynamics. The combination of hyperbaric oxygenation with drug therapy improves the effect of treatment significantly.
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PMID:[Hyperbaric oxygenation in the overall therapy of chronic ischemic heart disease]. 51 59

The life-span of methionie-Se75-labelled thrombocytes was studied in 46 patients with ischaemic heart disease and in 5 control individuals. In ischaemic heart disease patients the platelets life-span comprised 6.6+/-0.14 days, this period being smaller in patients over 60 years of age and in males, in contrast to younger patients and females. The presence of arterial hypertension and excessive body weight did not affect the life-span of the thrombocytes. Smoking, hypercholesterolemia and hypertriglyceridemia caused a statistically significant reduction of the circulation time of labelled thrombocytes. In patients with frequent attacks of angina pectoris and with postinfarction cardiosclerosis the life time of the platelets was shorter then in patients with painless forms of the disease and in those free of myocardial infarction. In Type II hyperlipoproteidemia the circulation period of labelled platelets comprised 6.3+/-0.16 days; in Type IV -- 6.7+/-0.29 days and in normolipemia -- 7.4+/-0.30 days. A distinct inverse correlation was established between the blood plasma cholesterol and thriglycerids level and the thrombocytes life-span. It was concluded that the reduction of the life-span of thrombocytes is attributed to the consumption of platelets by the processes of atherogenesis and chronic intravascular thrombus formation.
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PMID:[Types of hyperlipoproteinemia and thrombocyte survival in ischemic heart disease]. 88 45

The indices of contractility of the left ventricular myocardium were studied by means of ventriculography and catheterization in 84 patients with ischemic heart disease according to the extent of damage to the coronary arteries and the course of the disease. Changes in the coronary arteries were encountered twice as frequently among patients with postinfarction cardiosclerosis as among patients with angina pectoris and no history of infarction. The main cause of disorders of myocardial contractility in patients with ischemic heart disease is post-infarction cardiosclerosis (56% of cases). Signs of impaired functional capacity of the left ventricle appeared in segmental asynergy involving 20 to 25% of its circumference. Changes in the indices of contractility were revealed in 13% of patients with angina pectoris.
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PMID:[Myocardial contraction in ischemic heart disease]. 92 72

The examination was conducted in 77 patients with a varying course of acute myocardial infarction, in 10 normal individuals, 10 patients with angina pectoris, and 20 patients with post-infarction cardiosclerosis. The patients with acute myocardial infarction demonstrated a higher, than in the control group, blood viscosity, fibrinogen, hematocrit level and erythrocytes aggregation rate. The most significant changes in the rheologic properties of blood were observed in the cases of complicated myocardial infarction. Patients with severe coronary shock displayed both high and low levels of blood viscosity, fibrinogen and hematocrit, which may be due to the different stages of the coronary shock.
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PMID:[Rheologic properties of blood in patients with complicated and uncomplicated course of acute myocardial infarct]. 103 Jul 56

Data are presented on the differential diagnosis of some forms of the ischaemic heart disease, myocardial infarction including, performed with the help of a long--distance enquiry of the "Nairi-K" computer. This is one of the adjunct methods of early and timely diagnosis of myocardial infarction that permits to differentiate it from angina pectoris, postinfarction cardiosclerosis, acute abdominal pathology, pleuropneumonia, and to determine the localization of the necrosis. The exactness of the diagnosis ranges from 93 to 95%. An information system was developed that permits a more objective assessment of the nature of the ECG changes.
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PMID:[Differential diagnosis of acute myocardial infarct and ECG interpretation with the aid of long-distance computer inquiry]. 109 5

A total of 74 patients with postinfarct cardiosclerosis (PC) and stable angina (SA) were examined by Holter monitoring, bicycle ergometry, echocardiography and 201Tl chloride myocardial scintigraphy and loading tests (transesophageal cardiac pacing and isometric hand exercise test). The detection rate for silent myocardial ischemia (SI) was found to be 57.1% with Holter monitoring, 52.3% by bicycle ergometry, 62.5% with echocardiography, 100% with myocardial scintigraphy with loading test and 88.8% with that without the loading test. The detection rate for PC was 33.9, 32.0, 64.7, 81.8, and 56.7%, respectively. Higher SI detection rates in postinfarct patients were more frequently observed when echocardiography and myocardial scintigraphy in combination with loading tests in patients with PC without angina. The efficiency of SI detection in patients with various coronary heart disease increases when loading tests are employed. The loading tests in echocardiography and myocardial scintigraphy ensure the most complete detection of SI in postinfarct patients without angina.
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PMID:[Use of loading tests to detect silent myocardial ischemia]. 128 7

As many as 103 men who suffered myocardial infarction were examined for the clinical and functional manifestations of cerebral circulatory disorders as well as for the coronary heart disease at rest and during bicycle ergometry. The majority of the patients with postinfarction cardiosclerosis were found to have changes in the rheoencephalograms, augmenting with physical exercise. Those changes were most pronounced in patients with the clinical manifestations of atherosclerosis of cerebral vessels and in the presence of angina pectoris. The simultaneous recording of the rheoencephalogram and electrocardiogram during bicycle ergometry can be used for an all-round estimation of the reserves of cerebral and coronary circulation in patients suffering from coronary heart disease and elaboration of rehabilitation measures.
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PMID:[Rheoencephalography as an indicator of disorders of cerebral circulation in patients after myocardial infarction]. 132 77

The specific features of responses of the sympathoadrenal system during its activation by graded exercise (E), including that along with anaprilin induced blockade of beta-adrenoceptors, were determined from the urinary excretion of norepinephrine, epinephrine, dopamine, and dioxyphenylalanine in 54 healthy males and 22 patients with postinfarction cardiosclerosis concurrent with Functional Class I-II angina pectoris on effort. E caused hyperreactivity of the sympathoadrenal system, as appeared as significantly greater increases in the levels of catecholamines and their precursors in the patients than in the healthy persons. A single anaprilin dose of 40 mg abolished the responsiveness to exercise and improved its tolerance. The revealed features of sympathoadrenal responsiveness to exercise with and without anaprilin suggest that the patients with coronary heart disease have sympathoadrenal dysfunction, which shows one of the possible mechanisms responsible for the cardioprotective effect of beta-adrenoblockers in this disease.
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PMID:[The effect of anaprilin on the reaction of the sympathetic-adrenal system to graded physical loading in healthy subjects and patients with ischemic heart disease]. 148 74

The sera and high density lipoprotein (HDL) fraction obtained from donors and patients with coronary heart disease, Functional Class II exercise-induced angina or postinfarction cardiosclerosis were studied for levels of triglycerides (TG) and cholesterol (C) and calculated for percentage of HDL cholesterol of total serum cholesterol, C/TG and HDL C/HDL TG ratios. A TG-enriched HDL fraction was detected, which had an unusual structure. Calculation of the percentage of HDL C of serum total cholesterol levels much more revealed lower concentrations of HDL C.
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PMID:[The triglyceride content in the high-density lipoproteins of patients with ischemic heart disease]. 148 75


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